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Microbial Regulation of Glucose Metabolism and Insulin Resistance
Type 2 diabetes is a combined disease, resulting from a hyperglycemia and peripheral and hepatic insulin resistance. Recent data suggest that the gut microbiota is involved in diabetes development, altering metabolic processes including glucose and fatty acid metabolism. Thus, type 2 diabetes patien...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793163/ https://www.ncbi.nlm.nih.gov/pubmed/29286343 http://dx.doi.org/10.3390/genes9010010 |
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author | Crommen, Silke Simon, Marie-Christine |
author_facet | Crommen, Silke Simon, Marie-Christine |
author_sort | Crommen, Silke |
collection | PubMed |
description | Type 2 diabetes is a combined disease, resulting from a hyperglycemia and peripheral and hepatic insulin resistance. Recent data suggest that the gut microbiota is involved in diabetes development, altering metabolic processes including glucose and fatty acid metabolism. Thus, type 2 diabetes patients show a microbial dysbiosis, with reduced butyrate-producing bacteria and elevated potential pathogens compared to metabolically healthy individuals. Furthermore, probiotics are a known tool to modulate the microbiota, having a therapeutic potential. Current literature will be discussed to elucidate the complex interaction of gut microbiota, intestinal permeability and inflammation leading to peripheral and hepatic insulin resistance. Therefore, this review aims to generate a deeper understanding of the underlying mechanism of potential microbial strains, which can be used as probiotics. |
format | Online Article Text |
id | pubmed-5793163 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-57931632018-02-07 Microbial Regulation of Glucose Metabolism and Insulin Resistance Crommen, Silke Simon, Marie-Christine Genes (Basel) Review Type 2 diabetes is a combined disease, resulting from a hyperglycemia and peripheral and hepatic insulin resistance. Recent data suggest that the gut microbiota is involved in diabetes development, altering metabolic processes including glucose and fatty acid metabolism. Thus, type 2 diabetes patients show a microbial dysbiosis, with reduced butyrate-producing bacteria and elevated potential pathogens compared to metabolically healthy individuals. Furthermore, probiotics are a known tool to modulate the microbiota, having a therapeutic potential. Current literature will be discussed to elucidate the complex interaction of gut microbiota, intestinal permeability and inflammation leading to peripheral and hepatic insulin resistance. Therefore, this review aims to generate a deeper understanding of the underlying mechanism of potential microbial strains, which can be used as probiotics. MDPI 2017-12-29 /pmc/articles/PMC5793163/ /pubmed/29286343 http://dx.doi.org/10.3390/genes9010010 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Crommen, Silke Simon, Marie-Christine Microbial Regulation of Glucose Metabolism and Insulin Resistance |
title | Microbial Regulation of Glucose Metabolism and Insulin Resistance |
title_full | Microbial Regulation of Glucose Metabolism and Insulin Resistance |
title_fullStr | Microbial Regulation of Glucose Metabolism and Insulin Resistance |
title_full_unstemmed | Microbial Regulation of Glucose Metabolism and Insulin Resistance |
title_short | Microbial Regulation of Glucose Metabolism and Insulin Resistance |
title_sort | microbial regulation of glucose metabolism and insulin resistance |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793163/ https://www.ncbi.nlm.nih.gov/pubmed/29286343 http://dx.doi.org/10.3390/genes9010010 |
work_keys_str_mv | AT crommensilke microbialregulationofglucosemetabolismandinsulinresistance AT simonmariechristine microbialregulationofglucosemetabolismandinsulinresistance |