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SNCA Is a Functionally Low-Expressed Gene in Lung Adenocarcinoma

There is increasing evidence for the contribution of synuclein alpha (SNCA) to the etiology of neurological disorders, such as Parkinson’s disease (PD). However, little is known about the detailed role of SNCA in human cancers, especially lung cancers. Here, we evaluated the effects of SNCA on the o...

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Autores principales: Yan, Yuanliang, Xu, Zhijie, Hu, Xiaofang, Qian, Long, Li, Zhi, Zhou, Yangying, Dai, Shuang, Zeng, Shuangshuang, Gong, Zhicheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793169/
https://www.ncbi.nlm.nih.gov/pubmed/29300342
http://dx.doi.org/10.3390/genes9010016
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author Yan, Yuanliang
Xu, Zhijie
Hu, Xiaofang
Qian, Long
Li, Zhi
Zhou, Yangying
Dai, Shuang
Zeng, Shuangshuang
Gong, Zhicheng
author_facet Yan, Yuanliang
Xu, Zhijie
Hu, Xiaofang
Qian, Long
Li, Zhi
Zhou, Yangying
Dai, Shuang
Zeng, Shuangshuang
Gong, Zhicheng
author_sort Yan, Yuanliang
collection PubMed
description There is increasing evidence for the contribution of synuclein alpha (SNCA) to the etiology of neurological disorders, such as Parkinson’s disease (PD). However, little is known about the detailed role of SNCA in human cancers, especially lung cancers. Here, we evaluated the effects of SNCA on the occurrence and prognosis of lung adenocarcinoma (ADC). Comprehensive bioinformatics analyses of data obtained from the Oncomine platform, the human protein atlas (HPA) project and the cancer cell line encyclopedia (CCLE) demonstrated that SNCA expression was significantly reduced in both ADC tissues and cancer cells. The results of relevant clinical studies indicated that down-regulation of SNCA was statistically correlated with shorter overall survival time and post-progression survival time. Through analysis of datasets obtained from the Gene Expression Omnibus database, significant low levels of SNCA were identified in cisplatin-resistant ADC cells. Moreover, small interfering RNA (siRNA)-mediated knockdown of protein tyrosine kinase 7 (PTK7) elevated the expression of SNCA in the ADC cell lines H1299 and H2009. Our work demonstrates that low levels of SNCA are specifically found in ADC and that this gene may be a potential therapeutic target for this subset of lung cancers. Determination of the role of SNCA in ADC biology would give us some insightful information for further investigations.
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spelling pubmed-57931692018-02-07 SNCA Is a Functionally Low-Expressed Gene in Lung Adenocarcinoma Yan, Yuanliang Xu, Zhijie Hu, Xiaofang Qian, Long Li, Zhi Zhou, Yangying Dai, Shuang Zeng, Shuangshuang Gong, Zhicheng Genes (Basel) Article There is increasing evidence for the contribution of synuclein alpha (SNCA) to the etiology of neurological disorders, such as Parkinson’s disease (PD). However, little is known about the detailed role of SNCA in human cancers, especially lung cancers. Here, we evaluated the effects of SNCA on the occurrence and prognosis of lung adenocarcinoma (ADC). Comprehensive bioinformatics analyses of data obtained from the Oncomine platform, the human protein atlas (HPA) project and the cancer cell line encyclopedia (CCLE) demonstrated that SNCA expression was significantly reduced in both ADC tissues and cancer cells. The results of relevant clinical studies indicated that down-regulation of SNCA was statistically correlated with shorter overall survival time and post-progression survival time. Through analysis of datasets obtained from the Gene Expression Omnibus database, significant low levels of SNCA were identified in cisplatin-resistant ADC cells. Moreover, small interfering RNA (siRNA)-mediated knockdown of protein tyrosine kinase 7 (PTK7) elevated the expression of SNCA in the ADC cell lines H1299 and H2009. Our work demonstrates that low levels of SNCA are specifically found in ADC and that this gene may be a potential therapeutic target for this subset of lung cancers. Determination of the role of SNCA in ADC biology would give us some insightful information for further investigations. MDPI 2018-01-04 /pmc/articles/PMC5793169/ /pubmed/29300342 http://dx.doi.org/10.3390/genes9010016 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yan, Yuanliang
Xu, Zhijie
Hu, Xiaofang
Qian, Long
Li, Zhi
Zhou, Yangying
Dai, Shuang
Zeng, Shuangshuang
Gong, Zhicheng
SNCA Is a Functionally Low-Expressed Gene in Lung Adenocarcinoma
title SNCA Is a Functionally Low-Expressed Gene in Lung Adenocarcinoma
title_full SNCA Is a Functionally Low-Expressed Gene in Lung Adenocarcinoma
title_fullStr SNCA Is a Functionally Low-Expressed Gene in Lung Adenocarcinoma
title_full_unstemmed SNCA Is a Functionally Low-Expressed Gene in Lung Adenocarcinoma
title_short SNCA Is a Functionally Low-Expressed Gene in Lung Adenocarcinoma
title_sort snca is a functionally low-expressed gene in lung adenocarcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793169/
https://www.ncbi.nlm.nih.gov/pubmed/29300342
http://dx.doi.org/10.3390/genes9010016
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