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SNCA Is a Functionally Low-Expressed Gene in Lung Adenocarcinoma
There is increasing evidence for the contribution of synuclein alpha (SNCA) to the etiology of neurological disorders, such as Parkinson’s disease (PD). However, little is known about the detailed role of SNCA in human cancers, especially lung cancers. Here, we evaluated the effects of SNCA on the o...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793169/ https://www.ncbi.nlm.nih.gov/pubmed/29300342 http://dx.doi.org/10.3390/genes9010016 |
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author | Yan, Yuanliang Xu, Zhijie Hu, Xiaofang Qian, Long Li, Zhi Zhou, Yangying Dai, Shuang Zeng, Shuangshuang Gong, Zhicheng |
author_facet | Yan, Yuanliang Xu, Zhijie Hu, Xiaofang Qian, Long Li, Zhi Zhou, Yangying Dai, Shuang Zeng, Shuangshuang Gong, Zhicheng |
author_sort | Yan, Yuanliang |
collection | PubMed |
description | There is increasing evidence for the contribution of synuclein alpha (SNCA) to the etiology of neurological disorders, such as Parkinson’s disease (PD). However, little is known about the detailed role of SNCA in human cancers, especially lung cancers. Here, we evaluated the effects of SNCA on the occurrence and prognosis of lung adenocarcinoma (ADC). Comprehensive bioinformatics analyses of data obtained from the Oncomine platform, the human protein atlas (HPA) project and the cancer cell line encyclopedia (CCLE) demonstrated that SNCA expression was significantly reduced in both ADC tissues and cancer cells. The results of relevant clinical studies indicated that down-regulation of SNCA was statistically correlated with shorter overall survival time and post-progression survival time. Through analysis of datasets obtained from the Gene Expression Omnibus database, significant low levels of SNCA were identified in cisplatin-resistant ADC cells. Moreover, small interfering RNA (siRNA)-mediated knockdown of protein tyrosine kinase 7 (PTK7) elevated the expression of SNCA in the ADC cell lines H1299 and H2009. Our work demonstrates that low levels of SNCA are specifically found in ADC and that this gene may be a potential therapeutic target for this subset of lung cancers. Determination of the role of SNCA in ADC biology would give us some insightful information for further investigations. |
format | Online Article Text |
id | pubmed-5793169 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-57931692018-02-07 SNCA Is a Functionally Low-Expressed Gene in Lung Adenocarcinoma Yan, Yuanliang Xu, Zhijie Hu, Xiaofang Qian, Long Li, Zhi Zhou, Yangying Dai, Shuang Zeng, Shuangshuang Gong, Zhicheng Genes (Basel) Article There is increasing evidence for the contribution of synuclein alpha (SNCA) to the etiology of neurological disorders, such as Parkinson’s disease (PD). However, little is known about the detailed role of SNCA in human cancers, especially lung cancers. Here, we evaluated the effects of SNCA on the occurrence and prognosis of lung adenocarcinoma (ADC). Comprehensive bioinformatics analyses of data obtained from the Oncomine platform, the human protein atlas (HPA) project and the cancer cell line encyclopedia (CCLE) demonstrated that SNCA expression was significantly reduced in both ADC tissues and cancer cells. The results of relevant clinical studies indicated that down-regulation of SNCA was statistically correlated with shorter overall survival time and post-progression survival time. Through analysis of datasets obtained from the Gene Expression Omnibus database, significant low levels of SNCA were identified in cisplatin-resistant ADC cells. Moreover, small interfering RNA (siRNA)-mediated knockdown of protein tyrosine kinase 7 (PTK7) elevated the expression of SNCA in the ADC cell lines H1299 and H2009. Our work demonstrates that low levels of SNCA are specifically found in ADC and that this gene may be a potential therapeutic target for this subset of lung cancers. Determination of the role of SNCA in ADC biology would give us some insightful information for further investigations. MDPI 2018-01-04 /pmc/articles/PMC5793169/ /pubmed/29300342 http://dx.doi.org/10.3390/genes9010016 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yan, Yuanliang Xu, Zhijie Hu, Xiaofang Qian, Long Li, Zhi Zhou, Yangying Dai, Shuang Zeng, Shuangshuang Gong, Zhicheng SNCA Is a Functionally Low-Expressed Gene in Lung Adenocarcinoma |
title | SNCA Is a Functionally Low-Expressed Gene in Lung Adenocarcinoma |
title_full | SNCA Is a Functionally Low-Expressed Gene in Lung Adenocarcinoma |
title_fullStr | SNCA Is a Functionally Low-Expressed Gene in Lung Adenocarcinoma |
title_full_unstemmed | SNCA Is a Functionally Low-Expressed Gene in Lung Adenocarcinoma |
title_short | SNCA Is a Functionally Low-Expressed Gene in Lung Adenocarcinoma |
title_sort | snca is a functionally low-expressed gene in lung adenocarcinoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793169/ https://www.ncbi.nlm.nih.gov/pubmed/29300342 http://dx.doi.org/10.3390/genes9010016 |
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