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Scaffolding for Repair: Understanding Molecular Functions of the SMC5/6 Complex

Chromosome organization, dynamics and stability are required for successful passage through cellular generations and transmission of genetic information to offspring. The key components involved are Structural maintenance of chromosomes (SMC) complexes. Cohesin complex ensures proper chromatid align...

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Detalles Bibliográficos
Autores principales: Diaz, Mariana, Pecinka, Ales
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793187/
https://www.ncbi.nlm.nih.gov/pubmed/29329249
http://dx.doi.org/10.3390/genes9010036
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author Diaz, Mariana
Pecinka, Ales
author_facet Diaz, Mariana
Pecinka, Ales
author_sort Diaz, Mariana
collection PubMed
description Chromosome organization, dynamics and stability are required for successful passage through cellular generations and transmission of genetic information to offspring. The key components involved are Structural maintenance of chromosomes (SMC) complexes. Cohesin complex ensures proper chromatid alignment, condensin complex chromosome condensation and the SMC5/6 complex is specialized in the maintenance of genome stability. Here we summarize recent knowledge on the composition and molecular functions of SMC5/6 complex. SMC5/6 complex was originally identified based on the sensitivity of its mutants to genotoxic stress but there is increasing number of studies demonstrating its roles in the control of DNA replication, sister chromatid resolution and genomic location-dependent promotion or suppression of homologous recombination. Some of these functions appear to be due to a very dynamic interaction with cohesin or other repair complexes. Studies in Arabidopsis indicate that, besides its canonical function in repair of damaged DNA, the SMC5/6 complex plays important roles in regulating plant development, abiotic stress responses, suppression of autoimmune responses and sexual reproduction.
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spelling pubmed-57931872018-02-07 Scaffolding for Repair: Understanding Molecular Functions of the SMC5/6 Complex Diaz, Mariana Pecinka, Ales Genes (Basel) Review Chromosome organization, dynamics and stability are required for successful passage through cellular generations and transmission of genetic information to offspring. The key components involved are Structural maintenance of chromosomes (SMC) complexes. Cohesin complex ensures proper chromatid alignment, condensin complex chromosome condensation and the SMC5/6 complex is specialized in the maintenance of genome stability. Here we summarize recent knowledge on the composition and molecular functions of SMC5/6 complex. SMC5/6 complex was originally identified based on the sensitivity of its mutants to genotoxic stress but there is increasing number of studies demonstrating its roles in the control of DNA replication, sister chromatid resolution and genomic location-dependent promotion or suppression of homologous recombination. Some of these functions appear to be due to a very dynamic interaction with cohesin or other repair complexes. Studies in Arabidopsis indicate that, besides its canonical function in repair of damaged DNA, the SMC5/6 complex plays important roles in regulating plant development, abiotic stress responses, suppression of autoimmune responses and sexual reproduction. MDPI 2018-01-12 /pmc/articles/PMC5793187/ /pubmed/29329249 http://dx.doi.org/10.3390/genes9010036 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Diaz, Mariana
Pecinka, Ales
Scaffolding for Repair: Understanding Molecular Functions of the SMC5/6 Complex
title Scaffolding for Repair: Understanding Molecular Functions of the SMC5/6 Complex
title_full Scaffolding for Repair: Understanding Molecular Functions of the SMC5/6 Complex
title_fullStr Scaffolding for Repair: Understanding Molecular Functions of the SMC5/6 Complex
title_full_unstemmed Scaffolding for Repair: Understanding Molecular Functions of the SMC5/6 Complex
title_short Scaffolding for Repair: Understanding Molecular Functions of the SMC5/6 Complex
title_sort scaffolding for repair: understanding molecular functions of the smc5/6 complex
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793187/
https://www.ncbi.nlm.nih.gov/pubmed/29329249
http://dx.doi.org/10.3390/genes9010036
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