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Vitamin E (α- and γ-Tocopherol) Levels in the Community: Distribution, Clinical and Biochemical Correlates, and Association with Dietary Patterns

Little is known about the distribution and determinants of circulating vitamin E levels in a German population. In this cross-sectional study we assessed the distribution of both α- and γ-tocopherol levels, identified their clinical and biochemical correlates, and assessed their relationships with a...

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Autores principales: Waniek, Sabina, di Giuseppe, Romina, Esatbeyoglu, Tuba, Plachta-Danielzik, Sandra, Ratjen, Ilka, Jacobs, Gunnar, Nöthlings, Ute, Koch, Manja, Schlesinger, Sabrina, Rimbach, Gerald, Lieb, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793231/
https://www.ncbi.nlm.nih.gov/pubmed/29267223
http://dx.doi.org/10.3390/nu10010003
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author Waniek, Sabina
di Giuseppe, Romina
Esatbeyoglu, Tuba
Plachta-Danielzik, Sandra
Ratjen, Ilka
Jacobs, Gunnar
Nöthlings, Ute
Koch, Manja
Schlesinger, Sabrina
Rimbach, Gerald
Lieb, Wolfgang
author_facet Waniek, Sabina
di Giuseppe, Romina
Esatbeyoglu, Tuba
Plachta-Danielzik, Sandra
Ratjen, Ilka
Jacobs, Gunnar
Nöthlings, Ute
Koch, Manja
Schlesinger, Sabrina
Rimbach, Gerald
Lieb, Wolfgang
author_sort Waniek, Sabina
collection PubMed
description Little is known about the distribution and determinants of circulating vitamin E levels in a German population. In this cross-sectional study we assessed the distribution of both α- and γ-tocopherol levels, identified their clinical and biochemical correlates, and assessed their relationships with a priori and a posteriori derived dietary patterns. Plasma α- and γ-tocopherol concentrations were measured using high performance liquid chromatography (HPLC) with fluorescence detection in 641 individuals (mean-age: 61 years; 40.6% women). Correlates of both markers were determined using linear regression with backward selection. Using a validated food-frequency questionnaire (FFQ), an a priori defined vitamin E-rich dietary pattern was constructed, and three a posteriori derived dietary patterns were identified by principal component analysis. Each pattern was related to α- and γ-tocopherol levels using linear regression. Median concentrations of α- and γ-tocopherol were 31.54 μmol/L and 1.35 µmol/L, respectively. 57.6% of participants had α-tocopherol levels >30 µmol/L. Triglycerides, high density lipoprotein (HDL)- and low density lipoprotein (LDL)-cholesterol, and vitamin E supplementation were identified as correlates of vitamin E levels. After excluding supplement users, a dietary pattern rich in meat, bread, fats, potatoes, and sugar/confectionery was inversely related to α-tocopherol levels (β, −0.032, SE = 0.016; p = 0.047). Prospective studies are warranted to evaluate the actual impact of the reported findings in terms of nutrition and health outcomes.
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spelling pubmed-57932312018-02-06 Vitamin E (α- and γ-Tocopherol) Levels in the Community: Distribution, Clinical and Biochemical Correlates, and Association with Dietary Patterns Waniek, Sabina di Giuseppe, Romina Esatbeyoglu, Tuba Plachta-Danielzik, Sandra Ratjen, Ilka Jacobs, Gunnar Nöthlings, Ute Koch, Manja Schlesinger, Sabrina Rimbach, Gerald Lieb, Wolfgang Nutrients Article Little is known about the distribution and determinants of circulating vitamin E levels in a German population. In this cross-sectional study we assessed the distribution of both α- and γ-tocopherol levels, identified their clinical and biochemical correlates, and assessed their relationships with a priori and a posteriori derived dietary patterns. Plasma α- and γ-tocopherol concentrations were measured using high performance liquid chromatography (HPLC) with fluorescence detection in 641 individuals (mean-age: 61 years; 40.6% women). Correlates of both markers were determined using linear regression with backward selection. Using a validated food-frequency questionnaire (FFQ), an a priori defined vitamin E-rich dietary pattern was constructed, and three a posteriori derived dietary patterns were identified by principal component analysis. Each pattern was related to α- and γ-tocopherol levels using linear regression. Median concentrations of α- and γ-tocopherol were 31.54 μmol/L and 1.35 µmol/L, respectively. 57.6% of participants had α-tocopherol levels >30 µmol/L. Triglycerides, high density lipoprotein (HDL)- and low density lipoprotein (LDL)-cholesterol, and vitamin E supplementation were identified as correlates of vitamin E levels. After excluding supplement users, a dietary pattern rich in meat, bread, fats, potatoes, and sugar/confectionery was inversely related to α-tocopherol levels (β, −0.032, SE = 0.016; p = 0.047). Prospective studies are warranted to evaluate the actual impact of the reported findings in terms of nutrition and health outcomes. MDPI 2017-12-21 /pmc/articles/PMC5793231/ /pubmed/29267223 http://dx.doi.org/10.3390/nu10010003 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Waniek, Sabina
di Giuseppe, Romina
Esatbeyoglu, Tuba
Plachta-Danielzik, Sandra
Ratjen, Ilka
Jacobs, Gunnar
Nöthlings, Ute
Koch, Manja
Schlesinger, Sabrina
Rimbach, Gerald
Lieb, Wolfgang
Vitamin E (α- and γ-Tocopherol) Levels in the Community: Distribution, Clinical and Biochemical Correlates, and Association with Dietary Patterns
title Vitamin E (α- and γ-Tocopherol) Levels in the Community: Distribution, Clinical and Biochemical Correlates, and Association with Dietary Patterns
title_full Vitamin E (α- and γ-Tocopherol) Levels in the Community: Distribution, Clinical and Biochemical Correlates, and Association with Dietary Patterns
title_fullStr Vitamin E (α- and γ-Tocopherol) Levels in the Community: Distribution, Clinical and Biochemical Correlates, and Association with Dietary Patterns
title_full_unstemmed Vitamin E (α- and γ-Tocopherol) Levels in the Community: Distribution, Clinical and Biochemical Correlates, and Association with Dietary Patterns
title_short Vitamin E (α- and γ-Tocopherol) Levels in the Community: Distribution, Clinical and Biochemical Correlates, and Association with Dietary Patterns
title_sort vitamin e (α- and γ-tocopherol) levels in the community: distribution, clinical and biochemical correlates, and association with dietary patterns
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793231/
https://www.ncbi.nlm.nih.gov/pubmed/29267223
http://dx.doi.org/10.3390/nu10010003
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