Cargando…
Vitamin E (α- and γ-Tocopherol) Levels in the Community: Distribution, Clinical and Biochemical Correlates, and Association with Dietary Patterns
Little is known about the distribution and determinants of circulating vitamin E levels in a German population. In this cross-sectional study we assessed the distribution of both α- and γ-tocopherol levels, identified their clinical and biochemical correlates, and assessed their relationships with a...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793231/ https://www.ncbi.nlm.nih.gov/pubmed/29267223 http://dx.doi.org/10.3390/nu10010003 |
_version_ | 1783296903410089984 |
---|---|
author | Waniek, Sabina di Giuseppe, Romina Esatbeyoglu, Tuba Plachta-Danielzik, Sandra Ratjen, Ilka Jacobs, Gunnar Nöthlings, Ute Koch, Manja Schlesinger, Sabrina Rimbach, Gerald Lieb, Wolfgang |
author_facet | Waniek, Sabina di Giuseppe, Romina Esatbeyoglu, Tuba Plachta-Danielzik, Sandra Ratjen, Ilka Jacobs, Gunnar Nöthlings, Ute Koch, Manja Schlesinger, Sabrina Rimbach, Gerald Lieb, Wolfgang |
author_sort | Waniek, Sabina |
collection | PubMed |
description | Little is known about the distribution and determinants of circulating vitamin E levels in a German population. In this cross-sectional study we assessed the distribution of both α- and γ-tocopherol levels, identified their clinical and biochemical correlates, and assessed their relationships with a priori and a posteriori derived dietary patterns. Plasma α- and γ-tocopherol concentrations were measured using high performance liquid chromatography (HPLC) with fluorescence detection in 641 individuals (mean-age: 61 years; 40.6% women). Correlates of both markers were determined using linear regression with backward selection. Using a validated food-frequency questionnaire (FFQ), an a priori defined vitamin E-rich dietary pattern was constructed, and three a posteriori derived dietary patterns were identified by principal component analysis. Each pattern was related to α- and γ-tocopherol levels using linear regression. Median concentrations of α- and γ-tocopherol were 31.54 μmol/L and 1.35 µmol/L, respectively. 57.6% of participants had α-tocopherol levels >30 µmol/L. Triglycerides, high density lipoprotein (HDL)- and low density lipoprotein (LDL)-cholesterol, and vitamin E supplementation were identified as correlates of vitamin E levels. After excluding supplement users, a dietary pattern rich in meat, bread, fats, potatoes, and sugar/confectionery was inversely related to α-tocopherol levels (β, −0.032, SE = 0.016; p = 0.047). Prospective studies are warranted to evaluate the actual impact of the reported findings in terms of nutrition and health outcomes. |
format | Online Article Text |
id | pubmed-5793231 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-57932312018-02-06 Vitamin E (α- and γ-Tocopherol) Levels in the Community: Distribution, Clinical and Biochemical Correlates, and Association with Dietary Patterns Waniek, Sabina di Giuseppe, Romina Esatbeyoglu, Tuba Plachta-Danielzik, Sandra Ratjen, Ilka Jacobs, Gunnar Nöthlings, Ute Koch, Manja Schlesinger, Sabrina Rimbach, Gerald Lieb, Wolfgang Nutrients Article Little is known about the distribution and determinants of circulating vitamin E levels in a German population. In this cross-sectional study we assessed the distribution of both α- and γ-tocopherol levels, identified their clinical and biochemical correlates, and assessed their relationships with a priori and a posteriori derived dietary patterns. Plasma α- and γ-tocopherol concentrations were measured using high performance liquid chromatography (HPLC) with fluorescence detection in 641 individuals (mean-age: 61 years; 40.6% women). Correlates of both markers were determined using linear regression with backward selection. Using a validated food-frequency questionnaire (FFQ), an a priori defined vitamin E-rich dietary pattern was constructed, and three a posteriori derived dietary patterns were identified by principal component analysis. Each pattern was related to α- and γ-tocopherol levels using linear regression. Median concentrations of α- and γ-tocopherol were 31.54 μmol/L and 1.35 µmol/L, respectively. 57.6% of participants had α-tocopherol levels >30 µmol/L. Triglycerides, high density lipoprotein (HDL)- and low density lipoprotein (LDL)-cholesterol, and vitamin E supplementation were identified as correlates of vitamin E levels. After excluding supplement users, a dietary pattern rich in meat, bread, fats, potatoes, and sugar/confectionery was inversely related to α-tocopherol levels (β, −0.032, SE = 0.016; p = 0.047). Prospective studies are warranted to evaluate the actual impact of the reported findings in terms of nutrition and health outcomes. MDPI 2017-12-21 /pmc/articles/PMC5793231/ /pubmed/29267223 http://dx.doi.org/10.3390/nu10010003 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Waniek, Sabina di Giuseppe, Romina Esatbeyoglu, Tuba Plachta-Danielzik, Sandra Ratjen, Ilka Jacobs, Gunnar Nöthlings, Ute Koch, Manja Schlesinger, Sabrina Rimbach, Gerald Lieb, Wolfgang Vitamin E (α- and γ-Tocopherol) Levels in the Community: Distribution, Clinical and Biochemical Correlates, and Association with Dietary Patterns |
title | Vitamin E (α- and γ-Tocopherol) Levels in the Community: Distribution, Clinical and Biochemical Correlates, and Association with Dietary Patterns |
title_full | Vitamin E (α- and γ-Tocopherol) Levels in the Community: Distribution, Clinical and Biochemical Correlates, and Association with Dietary Patterns |
title_fullStr | Vitamin E (α- and γ-Tocopherol) Levels in the Community: Distribution, Clinical and Biochemical Correlates, and Association with Dietary Patterns |
title_full_unstemmed | Vitamin E (α- and γ-Tocopherol) Levels in the Community: Distribution, Clinical and Biochemical Correlates, and Association with Dietary Patterns |
title_short | Vitamin E (α- and γ-Tocopherol) Levels in the Community: Distribution, Clinical and Biochemical Correlates, and Association with Dietary Patterns |
title_sort | vitamin e (α- and γ-tocopherol) levels in the community: distribution, clinical and biochemical correlates, and association with dietary patterns |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793231/ https://www.ncbi.nlm.nih.gov/pubmed/29267223 http://dx.doi.org/10.3390/nu10010003 |
work_keys_str_mv | AT wanieksabina vitamineaandgtocopherollevelsinthecommunitydistributionclinicalandbiochemicalcorrelatesandassociationwithdietarypatterns AT digiusepperomina vitamineaandgtocopherollevelsinthecommunitydistributionclinicalandbiochemicalcorrelatesandassociationwithdietarypatterns AT esatbeyoglutuba vitamineaandgtocopherollevelsinthecommunitydistributionclinicalandbiochemicalcorrelatesandassociationwithdietarypatterns AT plachtadanielziksandra vitamineaandgtocopherollevelsinthecommunitydistributionclinicalandbiochemicalcorrelatesandassociationwithdietarypatterns AT ratjenilka vitamineaandgtocopherollevelsinthecommunitydistributionclinicalandbiochemicalcorrelatesandassociationwithdietarypatterns AT jacobsgunnar vitamineaandgtocopherollevelsinthecommunitydistributionclinicalandbiochemicalcorrelatesandassociationwithdietarypatterns AT nothlingsute vitamineaandgtocopherollevelsinthecommunitydistributionclinicalandbiochemicalcorrelatesandassociationwithdietarypatterns AT kochmanja vitamineaandgtocopherollevelsinthecommunitydistributionclinicalandbiochemicalcorrelatesandassociationwithdietarypatterns AT schlesingersabrina vitamineaandgtocopherollevelsinthecommunitydistributionclinicalandbiochemicalcorrelatesandassociationwithdietarypatterns AT rimbachgerald vitamineaandgtocopherollevelsinthecommunitydistributionclinicalandbiochemicalcorrelatesandassociationwithdietarypatterns AT liebwolfgang vitamineaandgtocopherollevelsinthecommunitydistributionclinicalandbiochemicalcorrelatesandassociationwithdietarypatterns |