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Tongue Abnormalities Are Associated to a Maternal Folic Acid Deficient Diet in Mice
It is widely accepted that maternal folic acid (FA) deficiency during pregnancy is a risk factor for abnormal development. The tongue, with multiple genes working together in a coordinated cascade in time and place, has emerged as a target organ for testing the effect of FA during development. A FA-...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793254/ https://www.ncbi.nlm.nih.gov/pubmed/29283374 http://dx.doi.org/10.3390/nu10010026 |
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author | Maldonado, Estela López-Gordillo, Yamila Partearroyo, Teresa Varela-Moreiras, Gregorio Martínez-Álvarez, Concepción Pérez-Miguelsanz, Juliana |
author_facet | Maldonado, Estela López-Gordillo, Yamila Partearroyo, Teresa Varela-Moreiras, Gregorio Martínez-Álvarez, Concepción Pérez-Miguelsanz, Juliana |
author_sort | Maldonado, Estela |
collection | PubMed |
description | It is widely accepted that maternal folic acid (FA) deficiency during pregnancy is a risk factor for abnormal development. The tongue, with multiple genes working together in a coordinated cascade in time and place, has emerged as a target organ for testing the effect of FA during development. A FA-deficient (FAD) diet was administered to eight-week-old C57/BL/6J mouse females for 2–16 weeks. Pregnant dams were sacrificed at gestational day 17 (E17). The tongues and heads of 15 control and 210 experimental fetuses were studied. In the tongues, the maximum width, base width, height and area were compared with width, height and area of the head. All measurements decreased from 10% to 38% with increasing number of weeks on maternal FAD diet. Decreased head and tongue areas showed a harmonic reduction (Spearman nonparametric correlation, Rho = 0.802) with respect to weeks on a maternal FAD diet. Tongue congenital abnormalities showed a 10.9% prevalence, divided in aglossia (3.3%) and microglossia (7.6%), always accompanied by agnathia (5.6%) or micrognathia (5.2%). This is the first time that tongue alterations have been related experimentally to maternal FAD diet in mice. We propose that the tongue should be included in the list of FA-sensitive birth defect organs due to its relevance in several key food and nutrition processes. |
format | Online Article Text |
id | pubmed-5793254 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-57932542018-02-06 Tongue Abnormalities Are Associated to a Maternal Folic Acid Deficient Diet in Mice Maldonado, Estela López-Gordillo, Yamila Partearroyo, Teresa Varela-Moreiras, Gregorio Martínez-Álvarez, Concepción Pérez-Miguelsanz, Juliana Nutrients Article It is widely accepted that maternal folic acid (FA) deficiency during pregnancy is a risk factor for abnormal development. The tongue, with multiple genes working together in a coordinated cascade in time and place, has emerged as a target organ for testing the effect of FA during development. A FA-deficient (FAD) diet was administered to eight-week-old C57/BL/6J mouse females for 2–16 weeks. Pregnant dams were sacrificed at gestational day 17 (E17). The tongues and heads of 15 control and 210 experimental fetuses were studied. In the tongues, the maximum width, base width, height and area were compared with width, height and area of the head. All measurements decreased from 10% to 38% with increasing number of weeks on maternal FAD diet. Decreased head and tongue areas showed a harmonic reduction (Spearman nonparametric correlation, Rho = 0.802) with respect to weeks on a maternal FAD diet. Tongue congenital abnormalities showed a 10.9% prevalence, divided in aglossia (3.3%) and microglossia (7.6%), always accompanied by agnathia (5.6%) or micrognathia (5.2%). This is the first time that tongue alterations have been related experimentally to maternal FAD diet in mice. We propose that the tongue should be included in the list of FA-sensitive birth defect organs due to its relevance in several key food and nutrition processes. MDPI 2017-12-28 /pmc/articles/PMC5793254/ /pubmed/29283374 http://dx.doi.org/10.3390/nu10010026 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Maldonado, Estela López-Gordillo, Yamila Partearroyo, Teresa Varela-Moreiras, Gregorio Martínez-Álvarez, Concepción Pérez-Miguelsanz, Juliana Tongue Abnormalities Are Associated to a Maternal Folic Acid Deficient Diet in Mice |
title | Tongue Abnormalities Are Associated to a Maternal Folic Acid Deficient Diet in Mice |
title_full | Tongue Abnormalities Are Associated to a Maternal Folic Acid Deficient Diet in Mice |
title_fullStr | Tongue Abnormalities Are Associated to a Maternal Folic Acid Deficient Diet in Mice |
title_full_unstemmed | Tongue Abnormalities Are Associated to a Maternal Folic Acid Deficient Diet in Mice |
title_short | Tongue Abnormalities Are Associated to a Maternal Folic Acid Deficient Diet in Mice |
title_sort | tongue abnormalities are associated to a maternal folic acid deficient diet in mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793254/ https://www.ncbi.nlm.nih.gov/pubmed/29283374 http://dx.doi.org/10.3390/nu10010026 |
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