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Tongue Abnormalities Are Associated to a Maternal Folic Acid Deficient Diet in Mice

It is widely accepted that maternal folic acid (FA) deficiency during pregnancy is a risk factor for abnormal development. The tongue, with multiple genes working together in a coordinated cascade in time and place, has emerged as a target organ for testing the effect of FA during development. A FA-...

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Autores principales: Maldonado, Estela, López-Gordillo, Yamila, Partearroyo, Teresa, Varela-Moreiras, Gregorio, Martínez-Álvarez, Concepción, Pérez-Miguelsanz, Juliana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793254/
https://www.ncbi.nlm.nih.gov/pubmed/29283374
http://dx.doi.org/10.3390/nu10010026
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author Maldonado, Estela
López-Gordillo, Yamila
Partearroyo, Teresa
Varela-Moreiras, Gregorio
Martínez-Álvarez, Concepción
Pérez-Miguelsanz, Juliana
author_facet Maldonado, Estela
López-Gordillo, Yamila
Partearroyo, Teresa
Varela-Moreiras, Gregorio
Martínez-Álvarez, Concepción
Pérez-Miguelsanz, Juliana
author_sort Maldonado, Estela
collection PubMed
description It is widely accepted that maternal folic acid (FA) deficiency during pregnancy is a risk factor for abnormal development. The tongue, with multiple genes working together in a coordinated cascade in time and place, has emerged as a target organ for testing the effect of FA during development. A FA-deficient (FAD) diet was administered to eight-week-old C57/BL/6J mouse females for 2–16 weeks. Pregnant dams were sacrificed at gestational day 17 (E17). The tongues and heads of 15 control and 210 experimental fetuses were studied. In the tongues, the maximum width, base width, height and area were compared with width, height and area of the head. All measurements decreased from 10% to 38% with increasing number of weeks on maternal FAD diet. Decreased head and tongue areas showed a harmonic reduction (Spearman nonparametric correlation, Rho = 0.802) with respect to weeks on a maternal FAD diet. Tongue congenital abnormalities showed a 10.9% prevalence, divided in aglossia (3.3%) and microglossia (7.6%), always accompanied by agnathia (5.6%) or micrognathia (5.2%). This is the first time that tongue alterations have been related experimentally to maternal FAD diet in mice. We propose that the tongue should be included in the list of FA-sensitive birth defect organs due to its relevance in several key food and nutrition processes.
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spelling pubmed-57932542018-02-06 Tongue Abnormalities Are Associated to a Maternal Folic Acid Deficient Diet in Mice Maldonado, Estela López-Gordillo, Yamila Partearroyo, Teresa Varela-Moreiras, Gregorio Martínez-Álvarez, Concepción Pérez-Miguelsanz, Juliana Nutrients Article It is widely accepted that maternal folic acid (FA) deficiency during pregnancy is a risk factor for abnormal development. The tongue, with multiple genes working together in a coordinated cascade in time and place, has emerged as a target organ for testing the effect of FA during development. A FA-deficient (FAD) diet was administered to eight-week-old C57/BL/6J mouse females for 2–16 weeks. Pregnant dams were sacrificed at gestational day 17 (E17). The tongues and heads of 15 control and 210 experimental fetuses were studied. In the tongues, the maximum width, base width, height and area were compared with width, height and area of the head. All measurements decreased from 10% to 38% with increasing number of weeks on maternal FAD diet. Decreased head and tongue areas showed a harmonic reduction (Spearman nonparametric correlation, Rho = 0.802) with respect to weeks on a maternal FAD diet. Tongue congenital abnormalities showed a 10.9% prevalence, divided in aglossia (3.3%) and microglossia (7.6%), always accompanied by agnathia (5.6%) or micrognathia (5.2%). This is the first time that tongue alterations have been related experimentally to maternal FAD diet in mice. We propose that the tongue should be included in the list of FA-sensitive birth defect organs due to its relevance in several key food and nutrition processes. MDPI 2017-12-28 /pmc/articles/PMC5793254/ /pubmed/29283374 http://dx.doi.org/10.3390/nu10010026 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Maldonado, Estela
López-Gordillo, Yamila
Partearroyo, Teresa
Varela-Moreiras, Gregorio
Martínez-Álvarez, Concepción
Pérez-Miguelsanz, Juliana
Tongue Abnormalities Are Associated to a Maternal Folic Acid Deficient Diet in Mice
title Tongue Abnormalities Are Associated to a Maternal Folic Acid Deficient Diet in Mice
title_full Tongue Abnormalities Are Associated to a Maternal Folic Acid Deficient Diet in Mice
title_fullStr Tongue Abnormalities Are Associated to a Maternal Folic Acid Deficient Diet in Mice
title_full_unstemmed Tongue Abnormalities Are Associated to a Maternal Folic Acid Deficient Diet in Mice
title_short Tongue Abnormalities Are Associated to a Maternal Folic Acid Deficient Diet in Mice
title_sort tongue abnormalities are associated to a maternal folic acid deficient diet in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793254/
https://www.ncbi.nlm.nih.gov/pubmed/29283374
http://dx.doi.org/10.3390/nu10010026
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