Mesenchymal stem cells in the osteosarcoma microenvironment: their biological properties, influence on tumor growth, and therapeutic implications

During tumorigenesis and development, participation of the tumor microenvironment is not negligible. As an important component in the tumor microenvironment, mesenchymal stem cells (MSCs) have been corroborated to mediate proliferation, metastasis, and drug resistance in many cancers, including oste...

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Autores principales: Zheng, Ying, Wang, Gangyang, Chen, Ruiling, Hua, Yingqi, Cai, Zhengdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793392/
https://www.ncbi.nlm.nih.gov/pubmed/29386041
http://dx.doi.org/10.1186/s13287-018-0780-x
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author Zheng, Ying
Wang, Gangyang
Chen, Ruiling
Hua, Yingqi
Cai, Zhengdong
author_facet Zheng, Ying
Wang, Gangyang
Chen, Ruiling
Hua, Yingqi
Cai, Zhengdong
author_sort Zheng, Ying
collection PubMed
description During tumorigenesis and development, participation of the tumor microenvironment is not negligible. As an important component in the tumor microenvironment, mesenchymal stem cells (MSCs) have been corroborated to mediate proliferation, metastasis, and drug resistance in many cancers, including osteosarcoma. What’s more, because of tumor site tropism, MSCs can be engineered to be loaded with therapeutic agents so that drugs can be precisely delivered to tumor lesions. In this review, we mainly discuss recent advances concerning the functions of MSCs in osteosarcoma and their possible clinical applications in the future.
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spelling pubmed-57933922018-02-12 Mesenchymal stem cells in the osteosarcoma microenvironment: their biological properties, influence on tumor growth, and therapeutic implications Zheng, Ying Wang, Gangyang Chen, Ruiling Hua, Yingqi Cai, Zhengdong Stem Cell Res Ther Review During tumorigenesis and development, participation of the tumor microenvironment is not negligible. As an important component in the tumor microenvironment, mesenchymal stem cells (MSCs) have been corroborated to mediate proliferation, metastasis, and drug resistance in many cancers, including osteosarcoma. What’s more, because of tumor site tropism, MSCs can be engineered to be loaded with therapeutic agents so that drugs can be precisely delivered to tumor lesions. In this review, we mainly discuss recent advances concerning the functions of MSCs in osteosarcoma and their possible clinical applications in the future. BioMed Central 2018-01-31 /pmc/articles/PMC5793392/ /pubmed/29386041 http://dx.doi.org/10.1186/s13287-018-0780-x Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Zheng, Ying
Wang, Gangyang
Chen, Ruiling
Hua, Yingqi
Cai, Zhengdong
Mesenchymal stem cells in the osteosarcoma microenvironment: their biological properties, influence on tumor growth, and therapeutic implications
title Mesenchymal stem cells in the osteosarcoma microenvironment: their biological properties, influence on tumor growth, and therapeutic implications
title_full Mesenchymal stem cells in the osteosarcoma microenvironment: their biological properties, influence on tumor growth, and therapeutic implications
title_fullStr Mesenchymal stem cells in the osteosarcoma microenvironment: their biological properties, influence on tumor growth, and therapeutic implications
title_full_unstemmed Mesenchymal stem cells in the osteosarcoma microenvironment: their biological properties, influence on tumor growth, and therapeutic implications
title_short Mesenchymal stem cells in the osteosarcoma microenvironment: their biological properties, influence on tumor growth, and therapeutic implications
title_sort mesenchymal stem cells in the osteosarcoma microenvironment: their biological properties, influence on tumor growth, and therapeutic implications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793392/
https://www.ncbi.nlm.nih.gov/pubmed/29386041
http://dx.doi.org/10.1186/s13287-018-0780-x
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