Synaptic dysfunction in complex psychiatric disorders: from genetics to mechanisms

Breakthroughs on many fronts have provided strong evidence to support synaptic dysfunction as a causal factor for neuropsychiatric diseases. Genetic studies have identified variants implicated in novel biological and synaptic pathways, and animal and patient-derived induced pluripotent stem cell-bas...

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Autores principales: Wang, Xinyuan, Christian, Kimberly M., Song, Hongjun, Ming, Guo-li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793422/
https://www.ncbi.nlm.nih.gov/pubmed/29386063
http://dx.doi.org/10.1186/s13073-018-0518-5
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author Wang, Xinyuan
Christian, Kimberly M.
Song, Hongjun
Ming, Guo-li
author_facet Wang, Xinyuan
Christian, Kimberly M.
Song, Hongjun
Ming, Guo-li
author_sort Wang, Xinyuan
collection PubMed
description Breakthroughs on many fronts have provided strong evidence to support synaptic dysfunction as a causal factor for neuropsychiatric diseases. Genetic studies have identified variants implicated in novel biological and synaptic pathways, and animal and patient-derived induced pluripotent stem cell-based models have allowed mechanistic investigations of synaptic dysfunction in pathological processes.
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spelling pubmed-57934222018-02-12 Synaptic dysfunction in complex psychiatric disorders: from genetics to mechanisms Wang, Xinyuan Christian, Kimberly M. Song, Hongjun Ming, Guo-li Genome Med Comment Breakthroughs on many fronts have provided strong evidence to support synaptic dysfunction as a causal factor for neuropsychiatric diseases. Genetic studies have identified variants implicated in novel biological and synaptic pathways, and animal and patient-derived induced pluripotent stem cell-based models have allowed mechanistic investigations of synaptic dysfunction in pathological processes. BioMed Central 2018-01-31 /pmc/articles/PMC5793422/ /pubmed/29386063 http://dx.doi.org/10.1186/s13073-018-0518-5 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Comment
Wang, Xinyuan
Christian, Kimberly M.
Song, Hongjun
Ming, Guo-li
Synaptic dysfunction in complex psychiatric disorders: from genetics to mechanisms
title Synaptic dysfunction in complex psychiatric disorders: from genetics to mechanisms
title_full Synaptic dysfunction in complex psychiatric disorders: from genetics to mechanisms
title_fullStr Synaptic dysfunction in complex psychiatric disorders: from genetics to mechanisms
title_full_unstemmed Synaptic dysfunction in complex psychiatric disorders: from genetics to mechanisms
title_short Synaptic dysfunction in complex psychiatric disorders: from genetics to mechanisms
title_sort synaptic dysfunction in complex psychiatric disorders: from genetics to mechanisms
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793422/
https://www.ncbi.nlm.nih.gov/pubmed/29386063
http://dx.doi.org/10.1186/s13073-018-0518-5
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