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Influence of new societal factors on neovascular age-related macular degeneration outcomes
BACKGROUND: To assess the impact of unstudied societal factors for neovascular age-related macular degeneration (nAMD) on functional outcomes after anti-VEGFs. METHODS: Charts of 94 nAMD patients treated in the Monticelli-Paradis Centre, Marseille, France, were reviewed. Phone interviews were conduc...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793434/ https://www.ncbi.nlm.nih.gov/pubmed/29385989 http://dx.doi.org/10.1186/s12886-018-0690-9 |
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author | Giocanti-Aurégan, Audrey Chbat, Elige Darugar, Adil Morel, Christophe Morin, Bruno Conrath, John Devin, François |
author_facet | Giocanti-Aurégan, Audrey Chbat, Elige Darugar, Adil Morel, Christophe Morin, Bruno Conrath, John Devin, François |
author_sort | Giocanti-Aurégan, Audrey |
collection | PubMed |
description | BACKGROUND: To assess the impact of unstudied societal factors for neovascular age-related macular degeneration (nAMD) on functional outcomes after anti-VEGFs. METHODS: Charts of 94 nAMD patients treated in the Monticelli-Paradis Centre, Marseille, France, were reviewed. Phone interviews were conducted to assess societal factors, including transportation, living status, daily reading and social security scheme (SSS). Primary outcome was the impact of family support and disease burden on functional improvement in nAMD. RESULTS: Between baseline and month 24 (M24), 42.4% of the variability in best-corrected visual acuity (BCVA) was explained by the cumulative effect of the following societal factors: intermittent out-patient follow-up, marital status, daily reading, transportation type, commuting time. No isolated societal factor significantly correlated with ETDRS BCVA severity at M24. A trend to correlation was observed between the EDTRS score at M24 and the SSS (P = 0.076), economic burden (P = 0.075), time between diagnosis and treatment initiation (P = 0.070). A significant correlation was found for the disease burdensome on the patient (P = 0.034) and low vision rehabilitation (P = 0.014). CONCLUSIONS: Societal factors could influence functional outcomes in nAMD patients treated with anti-VEGFs. They could contribute to the healing process or sustain disease progression. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12886-018-0690-9) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5793434 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-57934342018-02-12 Influence of new societal factors on neovascular age-related macular degeneration outcomes Giocanti-Aurégan, Audrey Chbat, Elige Darugar, Adil Morel, Christophe Morin, Bruno Conrath, John Devin, François BMC Ophthalmol Research Article BACKGROUND: To assess the impact of unstudied societal factors for neovascular age-related macular degeneration (nAMD) on functional outcomes after anti-VEGFs. METHODS: Charts of 94 nAMD patients treated in the Monticelli-Paradis Centre, Marseille, France, were reviewed. Phone interviews were conducted to assess societal factors, including transportation, living status, daily reading and social security scheme (SSS). Primary outcome was the impact of family support and disease burden on functional improvement in nAMD. RESULTS: Between baseline and month 24 (M24), 42.4% of the variability in best-corrected visual acuity (BCVA) was explained by the cumulative effect of the following societal factors: intermittent out-patient follow-up, marital status, daily reading, transportation type, commuting time. No isolated societal factor significantly correlated with ETDRS BCVA severity at M24. A trend to correlation was observed between the EDTRS score at M24 and the SSS (P = 0.076), economic burden (P = 0.075), time between diagnosis and treatment initiation (P = 0.070). A significant correlation was found for the disease burdensome on the patient (P = 0.034) and low vision rehabilitation (P = 0.014). CONCLUSIONS: Societal factors could influence functional outcomes in nAMD patients treated with anti-VEGFs. They could contribute to the healing process or sustain disease progression. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12886-018-0690-9) contains supplementary material, which is available to authorized users. BioMed Central 2018-02-01 /pmc/articles/PMC5793434/ /pubmed/29385989 http://dx.doi.org/10.1186/s12886-018-0690-9 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Giocanti-Aurégan, Audrey Chbat, Elige Darugar, Adil Morel, Christophe Morin, Bruno Conrath, John Devin, François Influence of new societal factors on neovascular age-related macular degeneration outcomes |
title | Influence of new societal factors on neovascular age-related macular degeneration outcomes |
title_full | Influence of new societal factors on neovascular age-related macular degeneration outcomes |
title_fullStr | Influence of new societal factors on neovascular age-related macular degeneration outcomes |
title_full_unstemmed | Influence of new societal factors on neovascular age-related macular degeneration outcomes |
title_short | Influence of new societal factors on neovascular age-related macular degeneration outcomes |
title_sort | influence of new societal factors on neovascular age-related macular degeneration outcomes |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793434/ https://www.ncbi.nlm.nih.gov/pubmed/29385989 http://dx.doi.org/10.1186/s12886-018-0690-9 |
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