Cargando…

3D Powder Printed Bioglass and β-Tricalcium Phosphate Bone Scaffolds

The use of both bioglass (BG) and β tricalcium phosphate (β-TCP) for bone replacement applications has been studied extensively due to the materials’ high biocompatibility and ability to resorb when implanted in the body. 3D printing has been explored as a fast and versatile technique for the fabric...

Descripción completa

Detalles Bibliográficos
Autores principales: Seidenstuecker, Michael, Kerr, Laura, Bernstein, Anke, Mayr, Hermann O., Suedkamp, Norbert P., Gadow, Rainer, Krieg, Peter, Hernandez Latorre, Sergio, Thomann, Ralf, Syrowatka, Frank, Esslinger, Steffen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793511/
https://www.ncbi.nlm.nih.gov/pubmed/29271932
http://dx.doi.org/10.3390/ma11010013
_version_ 1783296968954478592
author Seidenstuecker, Michael
Kerr, Laura
Bernstein, Anke
Mayr, Hermann O.
Suedkamp, Norbert P.
Gadow, Rainer
Krieg, Peter
Hernandez Latorre, Sergio
Thomann, Ralf
Syrowatka, Frank
Esslinger, Steffen
author_facet Seidenstuecker, Michael
Kerr, Laura
Bernstein, Anke
Mayr, Hermann O.
Suedkamp, Norbert P.
Gadow, Rainer
Krieg, Peter
Hernandez Latorre, Sergio
Thomann, Ralf
Syrowatka, Frank
Esslinger, Steffen
author_sort Seidenstuecker, Michael
collection PubMed
description The use of both bioglass (BG) and β tricalcium phosphate (β-TCP) for bone replacement applications has been studied extensively due to the materials’ high biocompatibility and ability to resorb when implanted in the body. 3D printing has been explored as a fast and versatile technique for the fabrication of porous bone scaffolds. This project investigates the effects of using different combinations of a composite BG and β-TCP powder for 3D printing of porous bone scaffolds. Porous 3D powder printed bone scaffolds of BG, β-TCP, 50/50 BG/β-TCP and 70/30 BG/β-TCP compositions were subject to a variety of characterization and biocompatibility tests. The porosity characteristics, surface roughness, mechanical strength, viability for cell proliferation, material cytotoxicity and in vitro bioactivity were assessed. The results show that the scaffolds can support osteoblast-like MG-63 cells growth both on the surface of and within the scaffold material and do not show alarming cytotoxicity; the porosity and surface characteristics of the scaffolds are appropriate. Of the two tested composite materials, the 70/30 BG/β-TCP scaffold proved to be superior in terms of biocompatibility and mechanical strength. The mechanical strength of the scaffolds makes them unsuitable for load bearing applications. However, they can be useful for other applications such as bone fillers.
format Online
Article
Text
id pubmed-5793511
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-57935112018-02-07 3D Powder Printed Bioglass and β-Tricalcium Phosphate Bone Scaffolds Seidenstuecker, Michael Kerr, Laura Bernstein, Anke Mayr, Hermann O. Suedkamp, Norbert P. Gadow, Rainer Krieg, Peter Hernandez Latorre, Sergio Thomann, Ralf Syrowatka, Frank Esslinger, Steffen Materials (Basel) Article The use of both bioglass (BG) and β tricalcium phosphate (β-TCP) for bone replacement applications has been studied extensively due to the materials’ high biocompatibility and ability to resorb when implanted in the body. 3D printing has been explored as a fast and versatile technique for the fabrication of porous bone scaffolds. This project investigates the effects of using different combinations of a composite BG and β-TCP powder for 3D printing of porous bone scaffolds. Porous 3D powder printed bone scaffolds of BG, β-TCP, 50/50 BG/β-TCP and 70/30 BG/β-TCP compositions were subject to a variety of characterization and biocompatibility tests. The porosity characteristics, surface roughness, mechanical strength, viability for cell proliferation, material cytotoxicity and in vitro bioactivity were assessed. The results show that the scaffolds can support osteoblast-like MG-63 cells growth both on the surface of and within the scaffold material and do not show alarming cytotoxicity; the porosity and surface characteristics of the scaffolds are appropriate. Of the two tested composite materials, the 70/30 BG/β-TCP scaffold proved to be superior in terms of biocompatibility and mechanical strength. The mechanical strength of the scaffolds makes them unsuitable for load bearing applications. However, they can be useful for other applications such as bone fillers. MDPI 2017-12-22 /pmc/articles/PMC5793511/ /pubmed/29271932 http://dx.doi.org/10.3390/ma11010013 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Seidenstuecker, Michael
Kerr, Laura
Bernstein, Anke
Mayr, Hermann O.
Suedkamp, Norbert P.
Gadow, Rainer
Krieg, Peter
Hernandez Latorre, Sergio
Thomann, Ralf
Syrowatka, Frank
Esslinger, Steffen
3D Powder Printed Bioglass and β-Tricalcium Phosphate Bone Scaffolds
title 3D Powder Printed Bioglass and β-Tricalcium Phosphate Bone Scaffolds
title_full 3D Powder Printed Bioglass and β-Tricalcium Phosphate Bone Scaffolds
title_fullStr 3D Powder Printed Bioglass and β-Tricalcium Phosphate Bone Scaffolds
title_full_unstemmed 3D Powder Printed Bioglass and β-Tricalcium Phosphate Bone Scaffolds
title_short 3D Powder Printed Bioglass and β-Tricalcium Phosphate Bone Scaffolds
title_sort 3d powder printed bioglass and β-tricalcium phosphate bone scaffolds
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793511/
https://www.ncbi.nlm.nih.gov/pubmed/29271932
http://dx.doi.org/10.3390/ma11010013
work_keys_str_mv AT seidenstueckermichael 3dpowderprintedbioglassandbtricalciumphosphatebonescaffolds
AT kerrlaura 3dpowderprintedbioglassandbtricalciumphosphatebonescaffolds
AT bernsteinanke 3dpowderprintedbioglassandbtricalciumphosphatebonescaffolds
AT mayrhermanno 3dpowderprintedbioglassandbtricalciumphosphatebonescaffolds
AT suedkampnorbertp 3dpowderprintedbioglassandbtricalciumphosphatebonescaffolds
AT gadowrainer 3dpowderprintedbioglassandbtricalciumphosphatebonescaffolds
AT kriegpeter 3dpowderprintedbioglassandbtricalciumphosphatebonescaffolds
AT hernandezlatorresergio 3dpowderprintedbioglassandbtricalciumphosphatebonescaffolds
AT thomannralf 3dpowderprintedbioglassandbtricalciumphosphatebonescaffolds
AT syrowatkafrank 3dpowderprintedbioglassandbtricalciumphosphatebonescaffolds
AT esslingersteffen 3dpowderprintedbioglassandbtricalciumphosphatebonescaffolds