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On the Role of Enterococci in the Bloodstream: Results of a Single-Center, Retrospective, Observational Study at a German University Hospital

This study assesses the clinical relevance of vancomycin-susceptible enterococci in bacteremic patients and compares it with bacteremia due to Staphylococcus aureus and Escherichia coli. During a 5-year-study interval, clinical and diagnostic features of patients with enterococcal bacteremia were co...

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Autores principales: Frickmann, Hagen, Köller, Kerstin, Veil, Irina, Weise, Mirjam, Ludyga, Alicja, Schwarz, Norbert Georg, Warnke, Philipp, Podbielski, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Akadémiai Kiadó 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793698/
https://www.ncbi.nlm.nih.gov/pubmed/29403657
http://dx.doi.org/10.1556/1886.2017.00030
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author Frickmann, Hagen
Köller, Kerstin
Veil, Irina
Weise, Mirjam
Ludyga, Alicja
Schwarz, Norbert Georg
Warnke, Philipp
Podbielski, Andreas
author_facet Frickmann, Hagen
Köller, Kerstin
Veil, Irina
Weise, Mirjam
Ludyga, Alicja
Schwarz, Norbert Georg
Warnke, Philipp
Podbielski, Andreas
author_sort Frickmann, Hagen
collection PubMed
description This study assesses the clinical relevance of vancomycin-susceptible enterococci in bacteremic patients and compares it with bacteremia due to Staphylococcus aureus and Escherichia coli. During a 5-year-study interval, clinical and diagnostic features of patients with enterococcal bacteremia were compared to those of patients with E. coli or S. aureus bacteremia. Each patient was only counted once per hospital stay. During the 5-year study interval, data from 267 patients with enterococcal bacteremia and from 661 patients with bacteremia due to E. coli or S. aureus were evaluated. In spite of a comparable risk of death, patients with enterococci more frequently needed catecholamines and invasive ventilation. Furthermore, enterococci were more frequently associated with a mixed bacterial flora in bloodstream infections. While fatal sepsis due to E. coli and S. aureus was associated with typical shock symptoms, this association was not confirmed for enterococci. Although enterococcal bacteremia is associated with a risk of dying comparable to that with bacteremia due to E. coli and S. aureus, a lower pathogenic potential of enterococci in bloodstream has to be acknowledged. Enterococci in the bloodstream are more likely to be an epiphenomenon of impending death than its major cause.
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spelling pubmed-57936982018-02-05 On the Role of Enterococci in the Bloodstream: Results of a Single-Center, Retrospective, Observational Study at a German University Hospital Frickmann, Hagen Köller, Kerstin Veil, Irina Weise, Mirjam Ludyga, Alicja Schwarz, Norbert Georg Warnke, Philipp Podbielski, Andreas Eur J Microbiol Immunol (Bp) Original Article This study assesses the clinical relevance of vancomycin-susceptible enterococci in bacteremic patients and compares it with bacteremia due to Staphylococcus aureus and Escherichia coli. During a 5-year-study interval, clinical and diagnostic features of patients with enterococcal bacteremia were compared to those of patients with E. coli or S. aureus bacteremia. Each patient was only counted once per hospital stay. During the 5-year study interval, data from 267 patients with enterococcal bacteremia and from 661 patients with bacteremia due to E. coli or S. aureus were evaluated. In spite of a comparable risk of death, patients with enterococci more frequently needed catecholamines and invasive ventilation. Furthermore, enterococci were more frequently associated with a mixed bacterial flora in bloodstream infections. While fatal sepsis due to E. coli and S. aureus was associated with typical shock symptoms, this association was not confirmed for enterococci. Although enterococcal bacteremia is associated with a risk of dying comparable to that with bacteremia due to E. coli and S. aureus, a lower pathogenic potential of enterococci in bloodstream has to be acknowledged. Enterococci in the bloodstream are more likely to be an epiphenomenon of impending death than its major cause. Akadémiai Kiadó 2017-10-19 /pmc/articles/PMC5793698/ /pubmed/29403657 http://dx.doi.org/10.1556/1886.2017.00030 Text en © 2017, The Author(s) http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and reproduction in any medium for non-commercial purposes, provided the original author and source are credited, a link to the CC License is provided, and changes – if any – are indicated.
spellingShingle Original Article
Frickmann, Hagen
Köller, Kerstin
Veil, Irina
Weise, Mirjam
Ludyga, Alicja
Schwarz, Norbert Georg
Warnke, Philipp
Podbielski, Andreas
On the Role of Enterococci in the Bloodstream: Results of a Single-Center, Retrospective, Observational Study at a German University Hospital
title On the Role of Enterococci in the Bloodstream: Results of a Single-Center, Retrospective, Observational Study at a German University Hospital
title_full On the Role of Enterococci in the Bloodstream: Results of a Single-Center, Retrospective, Observational Study at a German University Hospital
title_fullStr On the Role of Enterococci in the Bloodstream: Results of a Single-Center, Retrospective, Observational Study at a German University Hospital
title_full_unstemmed On the Role of Enterococci in the Bloodstream: Results of a Single-Center, Retrospective, Observational Study at a German University Hospital
title_short On the Role of Enterococci in the Bloodstream: Results of a Single-Center, Retrospective, Observational Study at a German University Hospital
title_sort on the role of enterococci in the bloodstream: results of a single-center, retrospective, observational study at a german university hospital
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793698/
https://www.ncbi.nlm.nih.gov/pubmed/29403657
http://dx.doi.org/10.1556/1886.2017.00030
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