Conserved non-AUG uORFs revealed by a novel regression analysis of ribosome profiling data

Upstream open reading frames (uORFs), located in transcript leaders (5′ UTRs), are potent cis-acting regulators of translation and mRNA turnover. Recent genome-wide ribosome profiling studies suggest that thousands of uORFs initiate with non-AUG start codons. Although intriguing, these non-AUG uORF...

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Detalles Bibliográficos
Autores principales: Spealman, Pieter, Naik, Armaghan W., May, Gemma E., Kuersten, Scott, Freeberg, Lindsay, Murphy, Robert F., McManus, Joel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793785/
https://www.ncbi.nlm.nih.gov/pubmed/29254944
http://dx.doi.org/10.1101/gr.221507.117

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