Precise and efficient nucleotide substitution near genomic nick via noncanonical homology-directed repair

CRISPR/Cas9, which generates DNA double-strand breaks (DSBs) at target loci, is a powerful tool for editing genomes when codelivered with a donor DNA template. However, DSBs, which are the most deleterious type of DNA damage, often result in unintended nucleotide insertions/deletions (indels) via mu...

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Detalles Bibliográficos
Autores principales: Nakajima, Kazuhiro, Zhou, Yue, Tomita, Akiko, Hirade, Yoshihiro, Gurumurthy, Channabasavaiah B., Nakada, Shinichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793786/
https://www.ncbi.nlm.nih.gov/pubmed/29273627
http://dx.doi.org/10.1101/gr.226027.117

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