Mapping protein interactions of sodium channel Na(V)1.7 using epitope‐tagged gene‐targeted mice

The voltage‐gated sodium channel Na(V)1.7 plays a critical role in pain pathways. We generated an epitope‐tagged Na(V)1.7 mouse that showed normal pain behaviours to identify channel‐interacting proteins. Analysis of Na(V)1.7 complexes affinity‐purified under native conditions by mass spectrometry r...

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Detalles Bibliográficos
Autores principales: Kanellopoulos, Alexandros H, Koenig, Jennifer, Huang, Honglei, Pyrski, Martina, Millet, Queensta, Lolignier, Stéphane, Morohashi, Toru, Gossage, Samuel J, Jay, Maude, Linley, John E, Baskozos, Georgios, Kessler, Benedikt M, Cox, James J, Dolphin, Annette C, Zufall, Frank, Wood, John N, Zhao, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Resource
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793798/
https://www.ncbi.nlm.nih.gov/pubmed/29335280
http://dx.doi.org/10.15252/embj.201796692

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