Cargando…
Bisphenol A, phthalate metabolites and glucose homeostasis in healthy normal-weight children
INTRODUCTION: Bisphenol A and several of the most commonly used phthalates have been associated with adverse metabolic health effects such as obesity and diabetes. Therefore, we analyzed these man-made chemicals in first morning urine samples from 107 healthy normal-weight Danish children and adoles...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bioscientifica Ltd
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793810/ https://www.ncbi.nlm.nih.gov/pubmed/29237763 http://dx.doi.org/10.1530/EC-17-0344 |
_version_ | 1783297025789394944 |
---|---|
author | Carlsson, Amalie Sørensen, Kaspar Andersson, Anna-Maria Frederiksen, Hanne Juul, Anders |
author_facet | Carlsson, Amalie Sørensen, Kaspar Andersson, Anna-Maria Frederiksen, Hanne Juul, Anders |
author_sort | Carlsson, Amalie |
collection | PubMed |
description | INTRODUCTION: Bisphenol A and several of the most commonly used phthalates have been associated with adverse metabolic health effects such as obesity and diabetes. Therefore, we analyzed these man-made chemicals in first morning urine samples from 107 healthy normal-weight Danish children and adolescents. METHOD: This was a cross-sectional study. Participants were recruited as part of the Copenhagen Puberty Study. The subjects were evaluated by an oral glucose tolerance test (OGTT), a dual-energy X-ray absorptiometry (DXA) scan, direct oxygen uptake measurement during cycle ergometry and fasting blood samples. First morning urine was collected and phthalate metabolites and BPA were measured by liquid chromatography-tandem mass spectrometry (LC–MS/MS) with prior enzymatic deconjugation. Individual chemical concentrations were divided into tertiles and analyzed in relation to biological outcome. RESULTS: Children in the lowest tertile of urinary BPA had significantly higher peak insulin levels during OGTT (P = 0.01), lower insulin sensitivity index (P < 0.01), higher leptin (P = 0.03), triglyceride (P < 0.01) and total cholesterol levels (P = 0.04), lower aerobic fitness (P = 0.02) and a tendency toward higher fat mass index (P = 0.1) compared with children in the highest tertile for uBPA. No significant differences in anthropometrics, body composition or glucose metabolism were associated with any of the phthalate metabolites measured. CONCLUSION: This pilot study on healthy normal-weight children suggests an inverse association between BPA and insulin resistance. Our findings contrast other cross-sectional studies showing a positive association for BPA, which may be due to confounding or reverse causation because diet is an important source of both BPA exposure and obesity. |
format | Online Article Text |
id | pubmed-5793810 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Bioscientifica Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-57938102018-02-06 Bisphenol A, phthalate metabolites and glucose homeostasis in healthy normal-weight children Carlsson, Amalie Sørensen, Kaspar Andersson, Anna-Maria Frederiksen, Hanne Juul, Anders Endocr Connect Research INTRODUCTION: Bisphenol A and several of the most commonly used phthalates have been associated with adverse metabolic health effects such as obesity and diabetes. Therefore, we analyzed these man-made chemicals in first morning urine samples from 107 healthy normal-weight Danish children and adolescents. METHOD: This was a cross-sectional study. Participants were recruited as part of the Copenhagen Puberty Study. The subjects were evaluated by an oral glucose tolerance test (OGTT), a dual-energy X-ray absorptiometry (DXA) scan, direct oxygen uptake measurement during cycle ergometry and fasting blood samples. First morning urine was collected and phthalate metabolites and BPA were measured by liquid chromatography-tandem mass spectrometry (LC–MS/MS) with prior enzymatic deconjugation. Individual chemical concentrations were divided into tertiles and analyzed in relation to biological outcome. RESULTS: Children in the lowest tertile of urinary BPA had significantly higher peak insulin levels during OGTT (P = 0.01), lower insulin sensitivity index (P < 0.01), higher leptin (P = 0.03), triglyceride (P < 0.01) and total cholesterol levels (P = 0.04), lower aerobic fitness (P = 0.02) and a tendency toward higher fat mass index (P = 0.1) compared with children in the highest tertile for uBPA. No significant differences in anthropometrics, body composition or glucose metabolism were associated with any of the phthalate metabolites measured. CONCLUSION: This pilot study on healthy normal-weight children suggests an inverse association between BPA and insulin resistance. Our findings contrast other cross-sectional studies showing a positive association for BPA, which may be due to confounding or reverse causation because diet is an important source of both BPA exposure and obesity. Bioscientifica Ltd 2017-12-13 /pmc/articles/PMC5793810/ /pubmed/29237763 http://dx.doi.org/10.1530/EC-17-0344 Text en © 2018 The authors http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Carlsson, Amalie Sørensen, Kaspar Andersson, Anna-Maria Frederiksen, Hanne Juul, Anders Bisphenol A, phthalate metabolites and glucose homeostasis in healthy normal-weight children |
title | Bisphenol A, phthalate metabolites and glucose homeostasis in healthy normal-weight children |
title_full | Bisphenol A, phthalate metabolites and glucose homeostasis in healthy normal-weight children |
title_fullStr | Bisphenol A, phthalate metabolites and glucose homeostasis in healthy normal-weight children |
title_full_unstemmed | Bisphenol A, phthalate metabolites and glucose homeostasis in healthy normal-weight children |
title_short | Bisphenol A, phthalate metabolites and glucose homeostasis in healthy normal-weight children |
title_sort | bisphenol a, phthalate metabolites and glucose homeostasis in healthy normal-weight children |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793810/ https://www.ncbi.nlm.nih.gov/pubmed/29237763 http://dx.doi.org/10.1530/EC-17-0344 |
work_keys_str_mv | AT carlssonamalie bisphenolaphthalatemetabolitesandglucosehomeostasisinhealthynormalweightchildren AT sørensenkaspar bisphenolaphthalatemetabolitesandglucosehomeostasisinhealthynormalweightchildren AT anderssonannamaria bisphenolaphthalatemetabolitesandglucosehomeostasisinhealthynormalweightchildren AT frederiksenhanne bisphenolaphthalatemetabolitesandglucosehomeostasisinhealthynormalweightchildren AT juulanders bisphenolaphthalatemetabolitesandglucosehomeostasisinhealthynormalweightchildren |