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Bisphenol A, phthalate metabolites and glucose homeostasis in healthy normal-weight children

INTRODUCTION: Bisphenol A and several of the most commonly used phthalates have been associated with adverse metabolic health effects such as obesity and diabetes. Therefore, we analyzed these man-made chemicals in first morning urine samples from 107 healthy normal-weight Danish children and adoles...

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Autores principales: Carlsson, Amalie, Sørensen, Kaspar, Andersson, Anna-Maria, Frederiksen, Hanne, Juul, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793810/
https://www.ncbi.nlm.nih.gov/pubmed/29237763
http://dx.doi.org/10.1530/EC-17-0344
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author Carlsson, Amalie
Sørensen, Kaspar
Andersson, Anna-Maria
Frederiksen, Hanne
Juul, Anders
author_facet Carlsson, Amalie
Sørensen, Kaspar
Andersson, Anna-Maria
Frederiksen, Hanne
Juul, Anders
author_sort Carlsson, Amalie
collection PubMed
description INTRODUCTION: Bisphenol A and several of the most commonly used phthalates have been associated with adverse metabolic health effects such as obesity and diabetes. Therefore, we analyzed these man-made chemicals in first morning urine samples from 107 healthy normal-weight Danish children and adolescents. METHOD: This was a cross-sectional study. Participants were recruited as part of the Copenhagen Puberty Study. The subjects were evaluated by an oral glucose tolerance test (OGTT), a dual-energy X-ray absorptiometry (DXA) scan, direct oxygen uptake measurement during cycle ergometry and fasting blood samples. First morning urine was collected and phthalate metabolites and BPA were measured by liquid chromatography-tandem mass spectrometry (LC–MS/MS) with prior enzymatic deconjugation. Individual chemical concentrations were divided into tertiles and analyzed in relation to biological outcome. RESULTS: Children in the lowest tertile of urinary BPA had significantly higher peak insulin levels during OGTT (P = 0.01), lower insulin sensitivity index (P < 0.01), higher leptin (P = 0.03), triglyceride (P < 0.01) and total cholesterol levels (P = 0.04), lower aerobic fitness (P = 0.02) and a tendency toward higher fat mass index (P = 0.1) compared with children in the highest tertile for uBPA. No significant differences in anthropometrics, body composition or glucose metabolism were associated with any of the phthalate metabolites measured. CONCLUSION: This pilot study on healthy normal-weight children suggests an inverse association between BPA and insulin resistance. Our findings contrast other cross-sectional studies showing a positive association for BPA, which may be due to confounding or reverse causation because diet is an important source of both BPA exposure and obesity.
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spelling pubmed-57938102018-02-06 Bisphenol A, phthalate metabolites and glucose homeostasis in healthy normal-weight children Carlsson, Amalie Sørensen, Kaspar Andersson, Anna-Maria Frederiksen, Hanne Juul, Anders Endocr Connect Research INTRODUCTION: Bisphenol A and several of the most commonly used phthalates have been associated with adverse metabolic health effects such as obesity and diabetes. Therefore, we analyzed these man-made chemicals in first morning urine samples from 107 healthy normal-weight Danish children and adolescents. METHOD: This was a cross-sectional study. Participants were recruited as part of the Copenhagen Puberty Study. The subjects were evaluated by an oral glucose tolerance test (OGTT), a dual-energy X-ray absorptiometry (DXA) scan, direct oxygen uptake measurement during cycle ergometry and fasting blood samples. First morning urine was collected and phthalate metabolites and BPA were measured by liquid chromatography-tandem mass spectrometry (LC–MS/MS) with prior enzymatic deconjugation. Individual chemical concentrations were divided into tertiles and analyzed in relation to biological outcome. RESULTS: Children in the lowest tertile of urinary BPA had significantly higher peak insulin levels during OGTT (P = 0.01), lower insulin sensitivity index (P < 0.01), higher leptin (P = 0.03), triglyceride (P < 0.01) and total cholesterol levels (P = 0.04), lower aerobic fitness (P = 0.02) and a tendency toward higher fat mass index (P = 0.1) compared with children in the highest tertile for uBPA. No significant differences in anthropometrics, body composition or glucose metabolism were associated with any of the phthalate metabolites measured. CONCLUSION: This pilot study on healthy normal-weight children suggests an inverse association between BPA and insulin resistance. Our findings contrast other cross-sectional studies showing a positive association for BPA, which may be due to confounding or reverse causation because diet is an important source of both BPA exposure and obesity. Bioscientifica Ltd 2017-12-13 /pmc/articles/PMC5793810/ /pubmed/29237763 http://dx.doi.org/10.1530/EC-17-0344 Text en © 2018 The authors http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Carlsson, Amalie
Sørensen, Kaspar
Andersson, Anna-Maria
Frederiksen, Hanne
Juul, Anders
Bisphenol A, phthalate metabolites and glucose homeostasis in healthy normal-weight children
title Bisphenol A, phthalate metabolites and glucose homeostasis in healthy normal-weight children
title_full Bisphenol A, phthalate metabolites and glucose homeostasis in healthy normal-weight children
title_fullStr Bisphenol A, phthalate metabolites and glucose homeostasis in healthy normal-weight children
title_full_unstemmed Bisphenol A, phthalate metabolites and glucose homeostasis in healthy normal-weight children
title_short Bisphenol A, phthalate metabolites and glucose homeostasis in healthy normal-weight children
title_sort bisphenol a, phthalate metabolites and glucose homeostasis in healthy normal-weight children
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793810/
https://www.ncbi.nlm.nih.gov/pubmed/29237763
http://dx.doi.org/10.1530/EC-17-0344
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