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Structural investigations on mechanism of lapatinib resistance caused by HER-2 mutants

HER-2 belongs to the human epidermal growth factor receptor (HER) family. Via different signal transduction pathways, HER-2 regulates normal cell proliferation, survival, and differentiation. Recently, it was reported that MCF10A, BT474, and MDA-MB-231 cells bearing the HER2 K753E mutation were resi...

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Detalles Bibliográficos
Autores principales:	Verma, Sharad, Goyal, Sukriti, Kumari, Anchala, Singh, Aditi, Jamal, Salma, Grover, Abhinav
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794075/ https://www.ncbi.nlm.nih.gov/pubmed/29389942 http://dx.doi.org/10.1371/journal.pone.0190942

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