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Molecular epidemiology of HIV-1 subtype A in former Soviet Union countries

While in other parts of the world it is on decline, incidence of HIV infection continues to rise in the former Soviet Union (FSU) countries. The present study was conducted to investigate the patterns and modes of HIV transmission in FSU countries. We performed phylogenetic analysis of publicly avai...

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Autores principales: Aibekova, Lazzat, Foley, Brian, Hortelano, Gonzalo, Raees, Muhammad, Abdraimov, Sabit, Toichuev, Rakhmanbek, Ali, Syed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794106/
https://www.ncbi.nlm.nih.gov/pubmed/29389951
http://dx.doi.org/10.1371/journal.pone.0191891
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author Aibekova, Lazzat
Foley, Brian
Hortelano, Gonzalo
Raees, Muhammad
Abdraimov, Sabit
Toichuev, Rakhmanbek
Ali, Syed
author_facet Aibekova, Lazzat
Foley, Brian
Hortelano, Gonzalo
Raees, Muhammad
Abdraimov, Sabit
Toichuev, Rakhmanbek
Ali, Syed
author_sort Aibekova, Lazzat
collection PubMed
description While in other parts of the world it is on decline, incidence of HIV infection continues to rise in the former Soviet Union (FSU) countries. The present study was conducted to investigate the patterns and modes of HIV transmission in FSU countries. We performed phylogenetic analysis of publicly available 2705 HIV-1 subtype A pol sequences from thirteen FSU countries: Armenia, Azerbaijan, Belarus, Estonia, Georgia, Kazakhstan, Kyrgyzstan, Latvia, Lithuania, Moldova, Russia, Ukraine and Uzbekistan. Our analysis showed that the clusters from FSU countries were intermixed, indicating a possible role of transmigration in HIV transmission. Injection drug use was found to be the most frequent mode of transmission, while the clusters from PWID and heterosexual transmission were intermixed, indicating bridging of HIV infection across populations. To control the expanding HIV epidemic in this region, harm reduction strategies should be focused on three modes of transmission, namely, cross-border migration, injection drug use and heterosexual.
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spelling pubmed-57941062018-02-16 Molecular epidemiology of HIV-1 subtype A in former Soviet Union countries Aibekova, Lazzat Foley, Brian Hortelano, Gonzalo Raees, Muhammad Abdraimov, Sabit Toichuev, Rakhmanbek Ali, Syed PLoS One Research Article While in other parts of the world it is on decline, incidence of HIV infection continues to rise in the former Soviet Union (FSU) countries. The present study was conducted to investigate the patterns and modes of HIV transmission in FSU countries. We performed phylogenetic analysis of publicly available 2705 HIV-1 subtype A pol sequences from thirteen FSU countries: Armenia, Azerbaijan, Belarus, Estonia, Georgia, Kazakhstan, Kyrgyzstan, Latvia, Lithuania, Moldova, Russia, Ukraine and Uzbekistan. Our analysis showed that the clusters from FSU countries were intermixed, indicating a possible role of transmigration in HIV transmission. Injection drug use was found to be the most frequent mode of transmission, while the clusters from PWID and heterosexual transmission were intermixed, indicating bridging of HIV infection across populations. To control the expanding HIV epidemic in this region, harm reduction strategies should be focused on three modes of transmission, namely, cross-border migration, injection drug use and heterosexual. Public Library of Science 2018-02-01 /pmc/articles/PMC5794106/ /pubmed/29389951 http://dx.doi.org/10.1371/journal.pone.0191891 Text en © 2018 Aibekova et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Aibekova, Lazzat
Foley, Brian
Hortelano, Gonzalo
Raees, Muhammad
Abdraimov, Sabit
Toichuev, Rakhmanbek
Ali, Syed
Molecular epidemiology of HIV-1 subtype A in former Soviet Union countries
title Molecular epidemiology of HIV-1 subtype A in former Soviet Union countries
title_full Molecular epidemiology of HIV-1 subtype A in former Soviet Union countries
title_fullStr Molecular epidemiology of HIV-1 subtype A in former Soviet Union countries
title_full_unstemmed Molecular epidemiology of HIV-1 subtype A in former Soviet Union countries
title_short Molecular epidemiology of HIV-1 subtype A in former Soviet Union countries
title_sort molecular epidemiology of hiv-1 subtype a in former soviet union countries
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794106/
https://www.ncbi.nlm.nih.gov/pubmed/29389951
http://dx.doi.org/10.1371/journal.pone.0191891
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