An oxidized abasic lesion inhibits base excision repair leading to DNA strand breaks in a trinucleotide repeat tract

Oxidative DNA damage and base excision repair (BER) play important roles in modulating trinucleotide repeat (TNR) instability that is associated with human neurodegenerative diseases and cancer. We have reported that BER of base lesions can lead to TNR instability. However, it is unknown if modifica...

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Detalles Bibliográficos
Autores principales: Beaver, Jill M., Lai, Yanhao, Rolle, Shantell J., Weng, Liwei, Greenberg, Marc M., Liu, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794147/
https://www.ncbi.nlm.nih.gov/pubmed/29389977
http://dx.doi.org/10.1371/journal.pone.0192148

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