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The antioxidant xanthorrhizol prevents amyloid-β-induced oxidative modification and inactivation of neprilysin
Activity of neprilysin (NEP), the major protease which cleaves amyloid-β peptide (Aβ), is reportedly reduced in the brains of patients with Alzheimer’s disease (AD). Accumulation of Aβ generates reactive oxygen species (ROS) such as 4-hydroxynonenal (HNE), and then reduces activities of Aβ-degrading...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Portland Press Ltd.
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794500/ https://www.ncbi.nlm.nih.gov/pubmed/29330223 http://dx.doi.org/10.1042/BSR20171611 |