Dysregulated fibronectin trafficking by Hsp90 inhibition restricts prostate cancer cell invasion

The molecular chaperone Hsp90 is overexpressed in prostate cancer (PCa) and is responsible for the folding, stabilization and maturation of multiple oncoproteins, which are implicated in PCa progression. Compared to first-in-class Hsp90 inhibitors such as 17-allylamino-demethoxygeldanamycin (17-AAG)...

Descripción completa

Detalles Bibliográficos
Autores principales: Armstrong, Heather K., Gillis, Joanna L., Johnson, Ian R. D., Nassar, Zeyad D., Moldovan, Max, Levrier, Claire, Sadowski, Martin C., Chin, Mei Yieng, Tomlinson Guns, Emma S., Tarulli, Gerard, Lynn, David J., Brooks, Douglas A., Selth, Luke A., Centenera, Margaret M., Butler, Lisa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794796/
https://www.ncbi.nlm.nih.gov/pubmed/29391407
http://dx.doi.org/10.1038/s41598-018-19871-4

Ejemplares similares

Ejemplares similares