Cargando…

Absorption, Distribution, Metabolism, and Excretion of [(14)C]-Volixibat in Healthy Men: Phase 1 Open-Label Study

BACKGROUND AND OBJECTIVES: Volixibat is a potent inhibitor of the apical sodium-dependent bile acid transporter in development for the treatment of nonalcoholic steatohepatitis. This phase 1, open-label study investigated the absorption, distribution, metabolism, and excretion of [(14)C]-volixibat i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Siebers, Nicholas, Palmer, Melissa, Silberg, Debra G., Jennings, Lee, Bliss, Caleb, Martin, Patrick T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2017
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794849/ https://www.ncbi.nlm.nih.gov/pubmed/28702877 http://dx.doi.org/10.1007/s13318-017-0429-7

Ejemplares similares

A randomised, double-blind, placebo-controlled phase 1 study of the safety, tolerability and pharmacodynamics of volixibat in overweight and obese but otherwise healthy adults: implications for treatment of non-alcoholic steatohepatitis
por: Palmer, Melissa, et al.
Publicado: (2018)

Absorption, distribution, metabolism, and excretion of [(14)C]-labeled naloxegol in healthy subjects
por: Bui, Khanh, et al.
Publicado: (2015)

Absorption, metabolism, excretion, and safety of [(14)C]almonertinib in healthy Chinese subjects
por: Zhou, Chen, et al.
Publicado: (2021)

Absorption, distribution, metabolism, and excretion of [(14)C]‐dasotraline in humans
por: Chen, Yu‐Luan, et al.
Publicado: (2016)

Absorption, distribution, metabolism and excretion of molidustat in healthy participants
por: Lentini, Silvia, et al.
Publicado: (2020)

Apical sodium-dependent bile acid transporter inhibition with volixibat improves metabolic aspects and components of non-alcoholic steatohepatitis in Ldlr-/-.Leiden mice
por: Salic, Kanita, et al.
Publicado: (2019)

Safety, tolerability and pharmacodynamics of apical sodium-dependent bile acid transporter inhibition with volixibat in healthy adults and patients with type 2 diabetes mellitus: a randomised placebo-controlled trial
por: Tiessen, Renger G., et al.
Publicado: (2018)

Absorption, metabolism and excretion of opicapone in human healthy volunteers
por: Loureiro, Ana I., et al.
Publicado: (2022)

Absorption, Distribution and Excretion of (14)C-Probimane in Mice Bearing Lewis Lung Carcinoma
por: Lu, Da-Yong, et al.
Publicado: (2010)

A phase I, single‐center, open‐label study to investigate the absorption, distribution, metabolism and excretion of encorafenib following a single oral dose of 100 mg [ (14)C] encorafenib in healthy male subjects
por: Wollenberg, Lance, et al.
Publicado: (2023)

Absorption, Metabolism, and Excretion of [(14)C]-Tebipenem Pivoxil Hydrobromide (TBP-PI-HBr) in Healthy Male Subjects
por: Gupta, Vipul K., et al.
Publicado: (2023)

Absorption and Excretion of Antipyrine
Publicado: (1888)

Absorption, metabolism and excretion of [(14)C]pomalidomide in humans following oral administration
por: Hoffmann, Matthew, et al.
Publicado: (2012)

Absorption, Distribution, Excretion, and Pharmacokinetics of (14)C-Pyronaridine Tetraphosphate in Male and Female Sprague-Dawley Rats
por: Park, Sang Hyun, et al.
Publicado: (2010)

Absorption, Distribution, and Excretion of (14)C-APX001 after Single-Dose Administration to Rats and Monkeys
por: Mansbach, Robert, et al.
Publicado: (2017)

Absorption, metabolism, and excretion of [ (14)C]dersimelagon, an investigational oral selective melanocortin 1 receptor agonist, in preclinical species and healthy volunteers
por: Tsuda, Minoru, et al.
Publicado: (2023)

Absorption, metabolism, and excretion of [(14)C]ponatinib after a single oral dose in humans
por: Ye, Yihua E., et al.
Publicado: (2017)

Metabolism and Excretion of Intravenous, Radio-Labeled Amisulpride in Healthy, Adult Volunteers
por: Fox, Gabriel M, et al.
Publicado: (2019)

Pharmacokinetics, absorption, distribution, metabolism and excretion of the MEK inhibitor zapnometinib in rats
por: Füll, Yvonne, et al.
Publicado: (2022)

The Absolute Bioavailability, Absorption, Distribution, Metabolism, and Excretion of BI 425809 Administered as an Oral Dose or an Oral Dose with an Intravenous Microtracer Dose of [(14)C]-BI 425809 in Healthy Males
por: Burkard, Ute, et al.
Publicado: (2021)

Diet in Disease: X.—Digestion—Absorption—Excretion
por: Hart, Ernest
Publicado: (1892)

Correction to: The Absolute Bioavailability, Absorption, Distribution, Metabolism, and Excretion of BI 425809 Administered as an Oral Dose or an Oral Dose with an Intravenous Microtracer Dose of [(14)C]‑BI 425809 in Healthy Males
por: Burkard, Ute, et al.
Publicado: (2022)

Absorption, Metabolism, and Excretion of [(14)C]-Tolebrutinib After Oral Administration in Humans, Contribution of the Metabolites to Pharmacological Activity
por: Nicolas, Olivier, et al.
Publicado: (2023)

1120. Absorption, Metabolism, and Excretion of [(14)C]-Tebipenem Pivoxil Hydrobromide (TBP-PI-HBr) Following a Single Oral Dose in Healthy Male Subjects
por: Gupta, Vipul K, et al.
Publicado: (2021)

Open-label, phase I, pharmacokinetic studies of abiraterone acetate in healthy men
por: Acharya, M., et al.
Publicado: (2012)

Intestinal absorption, organ distribution, and urinary excretion of the rare sugar D-psicose
por: Tsukamoto, Ikuko, et al.
Publicado: (2014)

Polymorphisms in genes involved in the absorption, distribution, metabolism, and excretion of drugs in the Kazakhs of Kazakhstan
por: Iskakova, Aisha N., et al.
Publicado: (2016)

Absorption, excretion, and retention of selenium from a high selenium yeast in men with a high intake of selenium
por: Bügel, Susanne, et al.
Publicado: (2008)

Observations on the Absorption, Excretion, Diffusion, and Acetylation of Sulfadiazine in Man
por: Sadusk, Joseph F., et al.
Publicado: (1941)

Observations on the Absorption, Excretion, Diffusion, and Acetylation of Sulfathiazole in Man
por: Sadusk, Joseph F., et al.
Publicado: (1940)

Evaluation of absorption, distribution, metabolism, and excretion of [(14)C]-rucaparib, a poly(ADP-ribose) polymerase inhibitor, in patients with advanced solid tumors
por: Liao, Mingxiang, et al.
Publicado: (2019)

1400. Mass Balance, Metabolism, and Excretion of [(14)C]-Plazomicin in Healthy Human Subjects
por: Choi, Taylor, et al.
Publicado: (2018)

Pharmacokinetics, Metabolism, and Excretion of Intravenous [14C]Difelikefalin in Healthy Subjects and Subjects on Hemodialysis
por: Stark, Jeffrey G., et al.
Publicado: (2023)

Absorption, distribution and excretion of intravenously injected (68)Ge/(68)Ga generator eluate in healthy rats, and estimation of human radiation dosimetry
por: Autio, Anu, et al.
Publicado: (2015)

The Absorption, Distribution and Excretion of (3)H-Chlorambucil in Rats Bearing the Yoshida Ascites Sarcoma
por: Hill, Bridget T., et al.
Publicado: (1971)

Absorption, distribution, metabolism and excretion of peginesatide, a novel erythropoiesis-stimulating agent, in rats
por: Woodburn, Kathryn W., et al.
Publicado: (2011)

Phthalate Excretion Pattern and Testicular Function: A Study of 881 Healthy Danish Men
por: Joensen, Ulla Nordström, et al.
Publicado: (2012)

Lycopene: A Critical Review of Digestion, Absorption, Metabolism, and Excretion
por: Arballo, Joseph, et al.
Publicado: (2021)

Characterization of the absorption, metabolism, excretion, and mass balance of gefapixant in humans
por: Nussbaum, Jesse C., et al.
Publicado: (2022)

Investigation of Intestinal Absorption and Excretion of Paracetamol in Streptozotocin-Induced Hyperglycemia
por: Mészáros, Petra, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_uth20gn8me3gk9higm4alsd1tp