Heterologous pathway assembly reveals molecular steps of fungal terreic acid biosynthesis

Terreic acid is a potential anticancer drug as it inhibits Bruton’s tyrosine kinase; however, its biosynthetic molecular steps remain unclear. In this work, the individual reactions of terreic acid biosynthesis were determined by stepwise pathway assembly in a heterologous host, Pichia pastoris, on...

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Detalles Bibliográficos
Autores principales: Kong, Chuixing, Huang, Hezhou, Xue, Ying, Liu, Yiqi, Peng, Qiangqiang, Liu, Qi, Xu, Qin, Zhu, Qiaoyun, Yin, Ying, Zhou, Xiangshan, Zhang, Yuanxing, Cai, Menghao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794859/
https://www.ncbi.nlm.nih.gov/pubmed/29391515
http://dx.doi.org/10.1038/s41598-018-20514-x

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