OCD-like behavior is caused by dysfunction of thalamo-amygdala circuits and upregulated TrkB/ERK-MAPK signaling as a result of SPRED2 deficiency

Obsessive-compulsive disorder (OCD) is a common neuropsychiatric disease affecting about 2% of the general population. It is characterized by persistent intrusive thoughts and repetitive ritualized behaviors. While gene variations, malfunction of cortico-striato-thalamo-cortical (CSTC) circuits, and...

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Detalles Bibliográficos
Autores principales: Ullrich, M, Weber, M, Post, A M, Popp, S, Grein, J, Zechner, M, Guerrero González, H, Kreis, A, Schmitt, A G, Üçeyler, N, Lesch, K-P, Schuh, K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794898/
https://www.ncbi.nlm.nih.gov/pubmed/28070119
http://dx.doi.org/10.1038/mp.2016.232

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