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Is the Prevalence of the Deficit Syndrome in Schizophrenia Higher than Estimated? Results of a Meta-Analysis

The primary and enduring presence of negative symptoms observed in a relatively homogeneous subgroup of patients with schizophrenia led to the concept of deficit syndrome (DS). Until date, it is considered that 20–25% of schizophrenia cohorts have DS. The aim of this meta-analysis was to determine t...

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Detalles Bibliográficos
Autores principales: López-Díaz, Álvaro, Lara, Ignacio, Lahera, Guillermo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Neuropsychiatric Association 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795038/
https://www.ncbi.nlm.nih.gov/pubmed/29422932
http://dx.doi.org/10.4306/pi.2018.15.1.94
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author López-Díaz, Álvaro
Lara, Ignacio
Lahera, Guillermo
author_facet López-Díaz, Álvaro
Lara, Ignacio
Lahera, Guillermo
author_sort López-Díaz, Álvaro
collection PubMed
description The primary and enduring presence of negative symptoms observed in a relatively homogeneous subgroup of patients with schizophrenia led to the concept of deficit syndrome (DS). Until date, it is considered that 20–25% of schizophrenia cohorts have DS. The aim of this meta-analysis was to determine the current prevalence of DS, including international and most recent studies. Thirteen observational studies met the inclusion criteria, comprising 2092 patients from eight countries. Pooled proportion of the DS subgroup was 32.64%, higher than previously reported. Based on our outcomes, up to one-third of patients with schizophrenia might have idiopathic and stable negative symptoms. This significant proportion of patients should be well represented in clinical trial's samples.
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spelling pubmed-57950382018-02-08 Is the Prevalence of the Deficit Syndrome in Schizophrenia Higher than Estimated? Results of a Meta-Analysis López-Díaz, Álvaro Lara, Ignacio Lahera, Guillermo Psychiatry Investig Brief Report The primary and enduring presence of negative symptoms observed in a relatively homogeneous subgroup of patients with schizophrenia led to the concept of deficit syndrome (DS). Until date, it is considered that 20–25% of schizophrenia cohorts have DS. The aim of this meta-analysis was to determine the current prevalence of DS, including international and most recent studies. Thirteen observational studies met the inclusion criteria, comprising 2092 patients from eight countries. Pooled proportion of the DS subgroup was 32.64%, higher than previously reported. Based on our outcomes, up to one-third of patients with schizophrenia might have idiopathic and stable negative symptoms. This significant proportion of patients should be well represented in clinical trial's samples. Korean Neuropsychiatric Association 2018-01 2018-01-16 /pmc/articles/PMC5795038/ /pubmed/29422932 http://dx.doi.org/10.4306/pi.2018.15.1.94 Text en Copyright © 2018 Korean Neuropsychiatric Association http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
López-Díaz, Álvaro
Lara, Ignacio
Lahera, Guillermo
Is the Prevalence of the Deficit Syndrome in Schizophrenia Higher than Estimated? Results of a Meta-Analysis
title Is the Prevalence of the Deficit Syndrome in Schizophrenia Higher than Estimated? Results of a Meta-Analysis
title_full Is the Prevalence of the Deficit Syndrome in Schizophrenia Higher than Estimated? Results of a Meta-Analysis
title_fullStr Is the Prevalence of the Deficit Syndrome in Schizophrenia Higher than Estimated? Results of a Meta-Analysis
title_full_unstemmed Is the Prevalence of the Deficit Syndrome in Schizophrenia Higher than Estimated? Results of a Meta-Analysis
title_short Is the Prevalence of the Deficit Syndrome in Schizophrenia Higher than Estimated? Results of a Meta-Analysis
title_sort is the prevalence of the deficit syndrome in schizophrenia higher than estimated? results of a meta-analysis
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795038/
https://www.ncbi.nlm.nih.gov/pubmed/29422932
http://dx.doi.org/10.4306/pi.2018.15.1.94
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