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Human metapneumovirus - what we know now

Human metapneumovirus (HMPV) is a leading cause of acute respiratory infection, particularly in children, immunocompromised patients, and the elderly. HMPV, which is closely related to avian metapneumovirus subtype C, has circulated for at least 65 years, and nearly every child will be infected with...

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Autores principales: Shafagati, Nazly, Williams, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795268/
https://www.ncbi.nlm.nih.gov/pubmed/29744035
http://dx.doi.org/10.12688/f1000research.12625.1
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author Shafagati, Nazly
Williams, John
author_facet Shafagati, Nazly
Williams, John
author_sort Shafagati, Nazly
collection PubMed
description Human metapneumovirus (HMPV) is a leading cause of acute respiratory infection, particularly in children, immunocompromised patients, and the elderly. HMPV, which is closely related to avian metapneumovirus subtype C, has circulated for at least 65 years, and nearly every child will be infected with HMPV by the age of 5. However, immunity is incomplete, and re-infections occur throughout adult life. Symptoms are similar to those of other respiratory viral infections, ranging from mild (cough, rhinorrhea, and fever) to more severe (bronchiolitis and pneumonia). The preferred method for diagnosis is reverse transcription-polymerase chain reaction as HMPV is difficult to culture. Although there have been many advances made in the past 16 years since its discovery, there are still no US Food and Drug Administration-approved antivirals or vaccines available to treat HMPV. Both small animal and non-human primate models have been established for the study of HMPV. This review will focus on the epidemiology, transmission, and clinical manifestations in humans as well as the animal models of HMPV pathogenesis and host immune response.
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spelling pubmed-57952682018-05-08 Human metapneumovirus - what we know now Shafagati, Nazly Williams, John F1000Res Review Human metapneumovirus (HMPV) is a leading cause of acute respiratory infection, particularly in children, immunocompromised patients, and the elderly. HMPV, which is closely related to avian metapneumovirus subtype C, has circulated for at least 65 years, and nearly every child will be infected with HMPV by the age of 5. However, immunity is incomplete, and re-infections occur throughout adult life. Symptoms are similar to those of other respiratory viral infections, ranging from mild (cough, rhinorrhea, and fever) to more severe (bronchiolitis and pneumonia). The preferred method for diagnosis is reverse transcription-polymerase chain reaction as HMPV is difficult to culture. Although there have been many advances made in the past 16 years since its discovery, there are still no US Food and Drug Administration-approved antivirals or vaccines available to treat HMPV. Both small animal and non-human primate models have been established for the study of HMPV. This review will focus on the epidemiology, transmission, and clinical manifestations in humans as well as the animal models of HMPV pathogenesis and host immune response. F1000 Research Limited 2018-02-01 /pmc/articles/PMC5795268/ /pubmed/29744035 http://dx.doi.org/10.12688/f1000research.12625.1 Text en Copyright: © 2018 Shafagati N and Williams J http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Shafagati, Nazly
Williams, John
Human metapneumovirus - what we know now
title Human metapneumovirus - what we know now
title_full Human metapneumovirus - what we know now
title_fullStr Human metapneumovirus - what we know now
title_full_unstemmed Human metapneumovirus - what we know now
title_short Human metapneumovirus - what we know now
title_sort human metapneumovirus - what we know now
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795268/
https://www.ncbi.nlm.nih.gov/pubmed/29744035
http://dx.doi.org/10.12688/f1000research.12625.1
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