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Granular cell tumors of the tongue: fibroma or schwannoma

BACKGROUND: Granular cell tumors are benign lesions that typically occur in the oral cavity, but can also be found in other sites. However, the characteristics of these tumors are unclear. Thus, the present study aimed to investigate the immunohistological characteristics of these tumors of the tong...

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Autores principales: Musha, Atsushi, Ogawa, Masaru, Yokoo, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795288/
https://www.ncbi.nlm.nih.gov/pubmed/29329562
http://dx.doi.org/10.1186/s13005-017-0158-9
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author Musha, Atsushi
Ogawa, Masaru
Yokoo, Satoshi
author_facet Musha, Atsushi
Ogawa, Masaru
Yokoo, Satoshi
author_sort Musha, Atsushi
collection PubMed
description BACKGROUND: Granular cell tumors are benign lesions that typically occur in the oral cavity, but can also be found in other sites. However, the characteristics of these tumors are unclear. Thus, the present study aimed to investigate the immunohistological characteristics of these tumors of the tongue. METHODS: Seven patients were treated for granular cell tumors of the tongue at our institution during 2003–2017. Paraffin-embedded specimens were available for all cases; thus, retrospective immunohistochemical analyses were performed. RESULTS: All cases exhibited cytoplasmic acidophilic granules in the muscle layer of the tumor. Both the normal nerve cells and tumor cells also stained positive for PGP9.5, NSE, calretinin, and GFAP. A nucleus of tumor cells was typically present in the margin. The PAS-positive granules were also positive for CD68 (a lysozyme glycoprotein marker). Various sizes of nerve fibers were observed in each tumor, and granular cells were observed in the nerve fibers of a representative case. CONCLUSIONS: Based on our immunohistological findings, granular cell tumors may be derived from Schwann cells, and the presence of CD68 indicates that Wallerian degeneration after nerve injury may be a contributor to tumor formation. Thus, a safe surgical margin is needed to detect the infiltrative growth of granular cell tumors.
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spelling pubmed-57952882018-02-12 Granular cell tumors of the tongue: fibroma or schwannoma Musha, Atsushi Ogawa, Masaru Yokoo, Satoshi Head Face Med Research BACKGROUND: Granular cell tumors are benign lesions that typically occur in the oral cavity, but can also be found in other sites. However, the characteristics of these tumors are unclear. Thus, the present study aimed to investigate the immunohistological characteristics of these tumors of the tongue. METHODS: Seven patients were treated for granular cell tumors of the tongue at our institution during 2003–2017. Paraffin-embedded specimens were available for all cases; thus, retrospective immunohistochemical analyses were performed. RESULTS: All cases exhibited cytoplasmic acidophilic granules in the muscle layer of the tumor. Both the normal nerve cells and tumor cells also stained positive for PGP9.5, NSE, calretinin, and GFAP. A nucleus of tumor cells was typically present in the margin. The PAS-positive granules were also positive for CD68 (a lysozyme glycoprotein marker). Various sizes of nerve fibers were observed in each tumor, and granular cells were observed in the nerve fibers of a representative case. CONCLUSIONS: Based on our immunohistological findings, granular cell tumors may be derived from Schwann cells, and the presence of CD68 indicates that Wallerian degeneration after nerve injury may be a contributor to tumor formation. Thus, a safe surgical margin is needed to detect the infiltrative growth of granular cell tumors. BioMed Central 2018-01-03 /pmc/articles/PMC5795288/ /pubmed/29329562 http://dx.doi.org/10.1186/s13005-017-0158-9 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Musha, Atsushi
Ogawa, Masaru
Yokoo, Satoshi
Granular cell tumors of the tongue: fibroma or schwannoma
title Granular cell tumors of the tongue: fibroma or schwannoma
title_full Granular cell tumors of the tongue: fibroma or schwannoma
title_fullStr Granular cell tumors of the tongue: fibroma or schwannoma
title_full_unstemmed Granular cell tumors of the tongue: fibroma or schwannoma
title_short Granular cell tumors of the tongue: fibroma or schwannoma
title_sort granular cell tumors of the tongue: fibroma or schwannoma
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795288/
https://www.ncbi.nlm.nih.gov/pubmed/29329562
http://dx.doi.org/10.1186/s13005-017-0158-9
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