Frequent overexpression of AMAP1, an Arf6 effector in cell invasion, is characteristic of the MMTV-PyMT rather than the MMTV-Neu human breast cancer model

BACKGROUND: The small GTPase Arf6 and its downstream effector AMAP1 (also called ASAP1/DDEF1) constitute a signaling pathway promoting cell invasion, in which AMAP1 interacts with several different proteins, including PRKD2, EPB41L5, paxillin, and cortactin. Components of this pathway are often over...

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Detalles Bibliográficos
Autores principales: Otsuka, Yutaro, Oikawa, Tsukasa, Yoshino, Hinako, Hashimoto, Shigeru, Handa, Haruka, Yamamoto, Hiroki, Hashimoto, Ari, Sabe, Hisataka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795291/
https://www.ncbi.nlm.nih.gov/pubmed/29329590
http://dx.doi.org/10.1186/s12964-017-0212-z

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