Cargando…
Decreased Resting-State Interhemispheric Functional Connectivity Correlated with Neurocognitive Deficits in Drug-Naive First-Episode Adolescent-Onset Schizophrenia
BACKGROUND: Given that adolescence is a critical epoch in the onset of schizophrenia, studying aberrant brain changes in adolescent-onset schizophrenia, particularly in patients with drug-naive first-episode schizophrenia, is important to understand the biological mechanism of this disorder. Previou...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795351/ https://www.ncbi.nlm.nih.gov/pubmed/29228204 http://dx.doi.org/10.1093/ijnp/pyx095 |
_version_ | 1783297278196318208 |
---|---|
author | Liu, Yi Guo, Wenbin Zhang, Yan Lv, Luxian Hu, Feihu Wu, Renrong Zhao, Jingping |
author_facet | Liu, Yi Guo, Wenbin Zhang, Yan Lv, Luxian Hu, Feihu Wu, Renrong Zhao, Jingping |
author_sort | Liu, Yi |
collection | PubMed |
description | BACKGROUND: Given that adolescence is a critical epoch in the onset of schizophrenia, studying aberrant brain changes in adolescent-onset schizophrenia, particularly in patients with drug-naive first-episode schizophrenia, is important to understand the biological mechanism of this disorder. Previous resting-state functional magnetic resonance imaging studies have shown abnormal functional connectivity in separate hemispheres in patients with adult-onset schizophrenia. Our aim to study adolescent-onset schizophrenia can provide clues for the early aetiology of schizophrenia. METHOD: A total of 48 drug-naïve, first-episode, adolescent-onset schizophrenia outpatients and 31 healthy controls underwent resting-state functional magnetic resonance imaging scans. Data were subjected to voxel-mirrored homotopic connectivity and support vector machine analyses. RESULTS: Compared with the healthy controls, the adolescent-onset schizophrenia group showed significantly lower voxel-mirrored homotopic connectivity values in different brain regions, including the fusiform gyrus, superior temporal gyrus/insula, precentral gyrus, and precuneus. Decreased voxel-mirrored homotopic connectivity values in the superior temporal gyrus/insula were significantly correlated with Trail-Making Test: Part A performance (r = −0.437, P = .002). A combination of the voxel-mirrored homotopic connectivity values in the precentral gyrus and precuneus may be used to discriminate patients with adolescent-onset schizophrenia from controls with satisfactory classification results, which showed sensitivity of 100%, specificity of 87.09%, and accuracy of 94.93%. CONCLUSION: Our findings highlight resting-state interhemispheric FC abnormalities within the sensorimotor network of patients with adolescent-onset schizophrenia and confirm the relationship between adolescent-onset schizophrenia and adult-onset schizophrenia. These findings suggest that reduced interhemispheric connectivity within the sensorimotor network has a pivotal role in the pathogenesis of schizophrenia. |
format | Online Article Text |
id | pubmed-5795351 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-57953512018-02-06 Decreased Resting-State Interhemispheric Functional Connectivity Correlated with Neurocognitive Deficits in Drug-Naive First-Episode Adolescent-Onset Schizophrenia Liu, Yi Guo, Wenbin Zhang, Yan Lv, Luxian Hu, Feihu Wu, Renrong Zhao, Jingping Int J Neuropsychopharmacol Regular Research Articles BACKGROUND: Given that adolescence is a critical epoch in the onset of schizophrenia, studying aberrant brain changes in adolescent-onset schizophrenia, particularly in patients with drug-naive first-episode schizophrenia, is important to understand the biological mechanism of this disorder. Previous resting-state functional magnetic resonance imaging studies have shown abnormal functional connectivity in separate hemispheres in patients with adult-onset schizophrenia. Our aim to study adolescent-onset schizophrenia can provide clues for the early aetiology of schizophrenia. METHOD: A total of 48 drug-naïve, first-episode, adolescent-onset schizophrenia outpatients and 31 healthy controls underwent resting-state functional magnetic resonance imaging scans. Data were subjected to voxel-mirrored homotopic connectivity and support vector machine analyses. RESULTS: Compared with the healthy controls, the adolescent-onset schizophrenia group showed significantly lower voxel-mirrored homotopic connectivity values in different brain regions, including the fusiform gyrus, superior temporal gyrus/insula, precentral gyrus, and precuneus. Decreased voxel-mirrored homotopic connectivity values in the superior temporal gyrus/insula were significantly correlated with Trail-Making Test: Part A performance (r = −0.437, P = .002). A combination of the voxel-mirrored homotopic connectivity values in the precentral gyrus and precuneus may be used to discriminate patients with adolescent-onset schizophrenia from controls with satisfactory classification results, which showed sensitivity of 100%, specificity of 87.09%, and accuracy of 94.93%. CONCLUSION: Our findings highlight resting-state interhemispheric FC abnormalities within the sensorimotor network of patients with adolescent-onset schizophrenia and confirm the relationship between adolescent-onset schizophrenia and adult-onset schizophrenia. These findings suggest that reduced interhemispheric connectivity within the sensorimotor network has a pivotal role in the pathogenesis of schizophrenia. Oxford University Press 2017-11-07 /pmc/articles/PMC5795351/ /pubmed/29228204 http://dx.doi.org/10.1093/ijnp/pyx095 Text en © The Author(s) 2017. Published by Oxford University Press on behalf of CINP. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Regular Research Articles Liu, Yi Guo, Wenbin Zhang, Yan Lv, Luxian Hu, Feihu Wu, Renrong Zhao, Jingping Decreased Resting-State Interhemispheric Functional Connectivity Correlated with Neurocognitive Deficits in Drug-Naive First-Episode Adolescent-Onset Schizophrenia |
title | Decreased Resting-State Interhemispheric Functional Connectivity Correlated with Neurocognitive Deficits in Drug-Naive First-Episode Adolescent-Onset Schizophrenia |
title_full | Decreased Resting-State Interhemispheric Functional Connectivity Correlated with Neurocognitive Deficits in Drug-Naive First-Episode Adolescent-Onset Schizophrenia |
title_fullStr | Decreased Resting-State Interhemispheric Functional Connectivity Correlated with Neurocognitive Deficits in Drug-Naive First-Episode Adolescent-Onset Schizophrenia |
title_full_unstemmed | Decreased Resting-State Interhemispheric Functional Connectivity Correlated with Neurocognitive Deficits in Drug-Naive First-Episode Adolescent-Onset Schizophrenia |
title_short | Decreased Resting-State Interhemispheric Functional Connectivity Correlated with Neurocognitive Deficits in Drug-Naive First-Episode Adolescent-Onset Schizophrenia |
title_sort | decreased resting-state interhemispheric functional connectivity correlated with neurocognitive deficits in drug-naive first-episode adolescent-onset schizophrenia |
topic | Regular Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795351/ https://www.ncbi.nlm.nih.gov/pubmed/29228204 http://dx.doi.org/10.1093/ijnp/pyx095 |
work_keys_str_mv | AT liuyi decreasedrestingstateinterhemisphericfunctionalconnectivitycorrelatedwithneurocognitivedeficitsindrugnaivefirstepisodeadolescentonsetschizophrenia AT guowenbin decreasedrestingstateinterhemisphericfunctionalconnectivitycorrelatedwithneurocognitivedeficitsindrugnaivefirstepisodeadolescentonsetschizophrenia AT zhangyan decreasedrestingstateinterhemisphericfunctionalconnectivitycorrelatedwithneurocognitivedeficitsindrugnaivefirstepisodeadolescentonsetschizophrenia AT lvluxian decreasedrestingstateinterhemisphericfunctionalconnectivitycorrelatedwithneurocognitivedeficitsindrugnaivefirstepisodeadolescentonsetschizophrenia AT hufeihu decreasedrestingstateinterhemisphericfunctionalconnectivitycorrelatedwithneurocognitivedeficitsindrugnaivefirstepisodeadolescentonsetschizophrenia AT wurenrong decreasedrestingstateinterhemisphericfunctionalconnectivitycorrelatedwithneurocognitivedeficitsindrugnaivefirstepisodeadolescentonsetschizophrenia AT zhaojingping decreasedrestingstateinterhemisphericfunctionalconnectivitycorrelatedwithneurocognitivedeficitsindrugnaivefirstepisodeadolescentonsetschizophrenia |