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Mapping Compulsivity in the DSM-5 Obsessive Compulsive and Related Disorders: Cognitive Domains, Neural Circuitry, and Treatment

Compulsions are repetitive, stereotyped thoughts and behaviors designed to reduce harm. Growing evidence suggests that the neurocognitive mechanisms mediating behavioral inhibition (motor inhibition, cognitive inflexibility) reversal learning and habit formation (shift from goal-directed to habitual...

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Autores principales: Fineberg, Naomi A, Apergis-Schoute, Annemieke M, Vaghi, Matilde M, Banca, Paula, Gillan, Claire M, Voon, Valerie, Chamberlain, Samuel R, Cinosi, Eduardo, Reid, Jemma, Shahper, Sonia, Bullmore, Edward T, Sahakian, Barbara J, Robbins, Trevor W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795357/
https://www.ncbi.nlm.nih.gov/pubmed/29036632
http://dx.doi.org/10.1093/ijnp/pyx088
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author Fineberg, Naomi A
Apergis-Schoute, Annemieke M
Vaghi, Matilde M
Banca, Paula
Gillan, Claire M
Voon, Valerie
Chamberlain, Samuel R
Cinosi, Eduardo
Reid, Jemma
Shahper, Sonia
Bullmore, Edward T
Sahakian, Barbara J
Robbins, Trevor W
author_facet Fineberg, Naomi A
Apergis-Schoute, Annemieke M
Vaghi, Matilde M
Banca, Paula
Gillan, Claire M
Voon, Valerie
Chamberlain, Samuel R
Cinosi, Eduardo
Reid, Jemma
Shahper, Sonia
Bullmore, Edward T
Sahakian, Barbara J
Robbins, Trevor W
author_sort Fineberg, Naomi A
collection PubMed
description Compulsions are repetitive, stereotyped thoughts and behaviors designed to reduce harm. Growing evidence suggests that the neurocognitive mechanisms mediating behavioral inhibition (motor inhibition, cognitive inflexibility) reversal learning and habit formation (shift from goal-directed to habitual responding) contribute toward compulsive activity in a broad range of disorders. In obsessive compulsive disorder, distributed network perturbation appears focused around the prefrontal cortex, caudate, putamen, and associated neuro-circuitry. Obsessive compulsive disorder-related attentional set-shifting deficits correlated with reduced resting state functional connectivity between the dorsal caudate and the ventrolateral prefrontal cortex on neuroimaging. In contrast, experimental provocation of obsessive compulsive disorder symptoms reduced neural activation in brain regions implicated in goal-directed behavioral control (ventromedial prefrontal cortex, caudate) with concordant increased activation in regions implicated in habit learning (presupplementary motor area, putamen). The ventromedial prefrontal cortex plays a multifaceted role, integrating affective evaluative processes, flexible behavior, and fear learning. Findings from a neuroimaging study of Pavlovian fear reversal, in which obsessive compulsive disorder patients failed to flexibly update fear responses despite normal initial fear conditioning, suggest there is an absence of ventromedial prefrontal cortex safety signaling in obsessive compulsive disorder, which potentially undermines explicit contingency knowledge and may help to explain the link between cognitive inflexibility, fear, and anxiety processing in compulsive disorders such as obsessive compulsive disorder.
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spelling pubmed-57953572018-02-06 Mapping Compulsivity in the DSM-5 Obsessive Compulsive and Related Disorders: Cognitive Domains, Neural Circuitry, and Treatment Fineberg, Naomi A Apergis-Schoute, Annemieke M Vaghi, Matilde M Banca, Paula Gillan, Claire M Voon, Valerie Chamberlain, Samuel R Cinosi, Eduardo Reid, Jemma Shahper, Sonia Bullmore, Edward T Sahakian, Barbara J Robbins, Trevor W Int J Neuropsychopharmacol Review Compulsions are repetitive, stereotyped thoughts and behaviors designed to reduce harm. Growing evidence suggests that the neurocognitive mechanisms mediating behavioral inhibition (motor inhibition, cognitive inflexibility) reversal learning and habit formation (shift from goal-directed to habitual responding) contribute toward compulsive activity in a broad range of disorders. In obsessive compulsive disorder, distributed network perturbation appears focused around the prefrontal cortex, caudate, putamen, and associated neuro-circuitry. Obsessive compulsive disorder-related attentional set-shifting deficits correlated with reduced resting state functional connectivity between the dorsal caudate and the ventrolateral prefrontal cortex on neuroimaging. In contrast, experimental provocation of obsessive compulsive disorder symptoms reduced neural activation in brain regions implicated in goal-directed behavioral control (ventromedial prefrontal cortex, caudate) with concordant increased activation in regions implicated in habit learning (presupplementary motor area, putamen). The ventromedial prefrontal cortex plays a multifaceted role, integrating affective evaluative processes, flexible behavior, and fear learning. Findings from a neuroimaging study of Pavlovian fear reversal, in which obsessive compulsive disorder patients failed to flexibly update fear responses despite normal initial fear conditioning, suggest there is an absence of ventromedial prefrontal cortex safety signaling in obsessive compulsive disorder, which potentially undermines explicit contingency knowledge and may help to explain the link between cognitive inflexibility, fear, and anxiety processing in compulsive disorders such as obsessive compulsive disorder. Oxford University Press 2017-09-23 /pmc/articles/PMC5795357/ /pubmed/29036632 http://dx.doi.org/10.1093/ijnp/pyx088 Text en © The Author 2017. Published by Oxford University Press on behalf of CINP. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Fineberg, Naomi A
Apergis-Schoute, Annemieke M
Vaghi, Matilde M
Banca, Paula
Gillan, Claire M
Voon, Valerie
Chamberlain, Samuel R
Cinosi, Eduardo
Reid, Jemma
Shahper, Sonia
Bullmore, Edward T
Sahakian, Barbara J
Robbins, Trevor W
Mapping Compulsivity in the DSM-5 Obsessive Compulsive and Related Disorders: Cognitive Domains, Neural Circuitry, and Treatment
title Mapping Compulsivity in the DSM-5 Obsessive Compulsive and Related Disorders: Cognitive Domains, Neural Circuitry, and Treatment
title_full Mapping Compulsivity in the DSM-5 Obsessive Compulsive and Related Disorders: Cognitive Domains, Neural Circuitry, and Treatment
title_fullStr Mapping Compulsivity in the DSM-5 Obsessive Compulsive and Related Disorders: Cognitive Domains, Neural Circuitry, and Treatment
title_full_unstemmed Mapping Compulsivity in the DSM-5 Obsessive Compulsive and Related Disorders: Cognitive Domains, Neural Circuitry, and Treatment
title_short Mapping Compulsivity in the DSM-5 Obsessive Compulsive and Related Disorders: Cognitive Domains, Neural Circuitry, and Treatment
title_sort mapping compulsivity in the dsm-5 obsessive compulsive and related disorders: cognitive domains, neural circuitry, and treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795357/
https://www.ncbi.nlm.nih.gov/pubmed/29036632
http://dx.doi.org/10.1093/ijnp/pyx088
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