Cargando…

RNA Interference Therapies for an HIV-1 Functional Cure

HIV-1 drug therapies can prevent disease progression but cannot eliminate HIV-1 viruses from an infected individual. While there is hope that elimination of HIV-1 can be achieved, several approaches to reach a functional cure (control of HIV-1 replication in the absence of drug therapy) are also und...

Descripción completa

Detalles Bibliográficos
Autores principales: Scarborough, Robert J., Gatignol, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795421/
https://www.ncbi.nlm.nih.gov/pubmed/29280961
http://dx.doi.org/10.3390/v10010008
_version_ 1783297292117213184
author Scarborough, Robert J.
Gatignol, Anne
author_facet Scarborough, Robert J.
Gatignol, Anne
author_sort Scarborough, Robert J.
collection PubMed
description HIV-1 drug therapies can prevent disease progression but cannot eliminate HIV-1 viruses from an infected individual. While there is hope that elimination of HIV-1 can be achieved, several approaches to reach a functional cure (control of HIV-1 replication in the absence of drug therapy) are also under investigation. One of these approaches is the transplant of HIV-1 resistant cells expressing anti-HIV-1 RNAs, proteins or peptides. Small RNAs that use RNA interference pathways to target HIV-1 replication have emerged as competitive candidates for cell transplant therapy and have been included in all gene combinations that have so far entered clinical trials. Here, we review RNA interference pathways in mammalian cells and the design of therapeutic small RNAs that use these pathways to target pathogenic RNA sequences. Studies that have been performed to identify anti-HIV-1 RNA interference therapeutics are also reviewed and perspectives on their use in combination gene therapy to functionally cure HIV-1 infection are provided.
format Online
Article
Text
id pubmed-5795421
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-57954212018-02-09 RNA Interference Therapies for an HIV-1 Functional Cure Scarborough, Robert J. Gatignol, Anne Viruses Review HIV-1 drug therapies can prevent disease progression but cannot eliminate HIV-1 viruses from an infected individual. While there is hope that elimination of HIV-1 can be achieved, several approaches to reach a functional cure (control of HIV-1 replication in the absence of drug therapy) are also under investigation. One of these approaches is the transplant of HIV-1 resistant cells expressing anti-HIV-1 RNAs, proteins or peptides. Small RNAs that use RNA interference pathways to target HIV-1 replication have emerged as competitive candidates for cell transplant therapy and have been included in all gene combinations that have so far entered clinical trials. Here, we review RNA interference pathways in mammalian cells and the design of therapeutic small RNAs that use these pathways to target pathogenic RNA sequences. Studies that have been performed to identify anti-HIV-1 RNA interference therapeutics are also reviewed and perspectives on their use in combination gene therapy to functionally cure HIV-1 infection are provided. MDPI 2017-12-27 /pmc/articles/PMC5795421/ /pubmed/29280961 http://dx.doi.org/10.3390/v10010008 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Scarborough, Robert J.
Gatignol, Anne
RNA Interference Therapies for an HIV-1 Functional Cure
title RNA Interference Therapies for an HIV-1 Functional Cure
title_full RNA Interference Therapies for an HIV-1 Functional Cure
title_fullStr RNA Interference Therapies for an HIV-1 Functional Cure
title_full_unstemmed RNA Interference Therapies for an HIV-1 Functional Cure
title_short RNA Interference Therapies for an HIV-1 Functional Cure
title_sort rna interference therapies for an hiv-1 functional cure
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795421/
https://www.ncbi.nlm.nih.gov/pubmed/29280961
http://dx.doi.org/10.3390/v10010008
work_keys_str_mv AT scarboroughrobertj rnainterferencetherapiesforanhiv1functionalcure
AT gatignolanne rnainterferencetherapiesforanhiv1functionalcure