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RNA Interference Therapies for an HIV-1 Functional Cure
HIV-1 drug therapies can prevent disease progression but cannot eliminate HIV-1 viruses from an infected individual. While there is hope that elimination of HIV-1 can be achieved, several approaches to reach a functional cure (control of HIV-1 replication in the absence of drug therapy) are also und...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795421/ https://www.ncbi.nlm.nih.gov/pubmed/29280961 http://dx.doi.org/10.3390/v10010008 |
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author | Scarborough, Robert J. Gatignol, Anne |
author_facet | Scarborough, Robert J. Gatignol, Anne |
author_sort | Scarborough, Robert J. |
collection | PubMed |
description | HIV-1 drug therapies can prevent disease progression but cannot eliminate HIV-1 viruses from an infected individual. While there is hope that elimination of HIV-1 can be achieved, several approaches to reach a functional cure (control of HIV-1 replication in the absence of drug therapy) are also under investigation. One of these approaches is the transplant of HIV-1 resistant cells expressing anti-HIV-1 RNAs, proteins or peptides. Small RNAs that use RNA interference pathways to target HIV-1 replication have emerged as competitive candidates for cell transplant therapy and have been included in all gene combinations that have so far entered clinical trials. Here, we review RNA interference pathways in mammalian cells and the design of therapeutic small RNAs that use these pathways to target pathogenic RNA sequences. Studies that have been performed to identify anti-HIV-1 RNA interference therapeutics are also reviewed and perspectives on their use in combination gene therapy to functionally cure HIV-1 infection are provided. |
format | Online Article Text |
id | pubmed-5795421 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-57954212018-02-09 RNA Interference Therapies for an HIV-1 Functional Cure Scarborough, Robert J. Gatignol, Anne Viruses Review HIV-1 drug therapies can prevent disease progression but cannot eliminate HIV-1 viruses from an infected individual. While there is hope that elimination of HIV-1 can be achieved, several approaches to reach a functional cure (control of HIV-1 replication in the absence of drug therapy) are also under investigation. One of these approaches is the transplant of HIV-1 resistant cells expressing anti-HIV-1 RNAs, proteins or peptides. Small RNAs that use RNA interference pathways to target HIV-1 replication have emerged as competitive candidates for cell transplant therapy and have been included in all gene combinations that have so far entered clinical trials. Here, we review RNA interference pathways in mammalian cells and the design of therapeutic small RNAs that use these pathways to target pathogenic RNA sequences. Studies that have been performed to identify anti-HIV-1 RNA interference therapeutics are also reviewed and perspectives on their use in combination gene therapy to functionally cure HIV-1 infection are provided. MDPI 2017-12-27 /pmc/articles/PMC5795421/ /pubmed/29280961 http://dx.doi.org/10.3390/v10010008 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Scarborough, Robert J. Gatignol, Anne RNA Interference Therapies for an HIV-1 Functional Cure |
title | RNA Interference Therapies for an HIV-1 Functional Cure |
title_full | RNA Interference Therapies for an HIV-1 Functional Cure |
title_fullStr | RNA Interference Therapies for an HIV-1 Functional Cure |
title_full_unstemmed | RNA Interference Therapies for an HIV-1 Functional Cure |
title_short | RNA Interference Therapies for an HIV-1 Functional Cure |
title_sort | rna interference therapies for an hiv-1 functional cure |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795421/ https://www.ncbi.nlm.nih.gov/pubmed/29280961 http://dx.doi.org/10.3390/v10010008 |
work_keys_str_mv | AT scarboroughrobertj rnainterferencetherapiesforanhiv1functionalcure AT gatignolanne rnainterferencetherapiesforanhiv1functionalcure |