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Cytomegaloviruses in a Community of Wild Nonhuman Primates in Taï National Park, Côte D’Ivoire

Cytomegaloviruses (CMVs) are known to infect many mammals, including a number of nonhuman primates (NHPs). However, most data available arose from studies led on captive individuals and little is known about CMV diversity in wild NHPs. Here, we analyzed a community of wild nonhuman primates (seven s...

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Autores principales: Anoh, Augustin Etile, Murthy, Sripriya, Akoua-Koffi, Chantal, Couacy-Hymann, Emmanuel, Leendertz, Fabian Hubertus, Calvignac-Spencer, Sébastien, Ehlers, Bernhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795424/
https://www.ncbi.nlm.nih.gov/pubmed/29286318
http://dx.doi.org/10.3390/v10010011
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author Anoh, Augustin Etile
Murthy, Sripriya
Akoua-Koffi, Chantal
Couacy-Hymann, Emmanuel
Leendertz, Fabian Hubertus
Calvignac-Spencer, Sébastien
Ehlers, Bernhard
author_facet Anoh, Augustin Etile
Murthy, Sripriya
Akoua-Koffi, Chantal
Couacy-Hymann, Emmanuel
Leendertz, Fabian Hubertus
Calvignac-Spencer, Sébastien
Ehlers, Bernhard
author_sort Anoh, Augustin Etile
collection PubMed
description Cytomegaloviruses (CMVs) are known to infect many mammals, including a number of nonhuman primates (NHPs). However, most data available arose from studies led on captive individuals and little is known about CMV diversity in wild NHPs. Here, we analyzed a community of wild nonhuman primates (seven species) in Taï National Park (TNP), Côte d’Ivoire, with two PCR systems targeting betaherpesviruses. CMV DNA was detected in 17/87 primates (4/7 species). Six novel CMVs were identified in sooty mangabeys, Campbell’s monkeys and Diana monkeys, respectively. In 3/17 positive individuals (from three NHP species), different CMVs were co-detected. A major part of the glycoprotein B coding sequences of the novel viruses was amplified and sequenced, and phylogenetic analyses were performed that included three previously discovered CMVs of western red colobus from TNP and published CMVs from other NHP species and geographic locations. We find that, despite this locally intensified sampling, NHP CMVs from TNP are completely host-specific, pinpointing the absence or rarity of cross-species transmission. We also show that on longer timescales the evolution of CMVs is characterized by frequent co-divergence with their hosts, although other processes, including lineage duplication and host switching, also have to be invoked to fully explain their evolutionary relationships.
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spelling pubmed-57954242018-02-09 Cytomegaloviruses in a Community of Wild Nonhuman Primates in Taï National Park, Côte D’Ivoire Anoh, Augustin Etile Murthy, Sripriya Akoua-Koffi, Chantal Couacy-Hymann, Emmanuel Leendertz, Fabian Hubertus Calvignac-Spencer, Sébastien Ehlers, Bernhard Viruses Article Cytomegaloviruses (CMVs) are known to infect many mammals, including a number of nonhuman primates (NHPs). However, most data available arose from studies led on captive individuals and little is known about CMV diversity in wild NHPs. Here, we analyzed a community of wild nonhuman primates (seven species) in Taï National Park (TNP), Côte d’Ivoire, with two PCR systems targeting betaherpesviruses. CMV DNA was detected in 17/87 primates (4/7 species). Six novel CMVs were identified in sooty mangabeys, Campbell’s monkeys and Diana monkeys, respectively. In 3/17 positive individuals (from three NHP species), different CMVs were co-detected. A major part of the glycoprotein B coding sequences of the novel viruses was amplified and sequenced, and phylogenetic analyses were performed that included three previously discovered CMVs of western red colobus from TNP and published CMVs from other NHP species and geographic locations. We find that, despite this locally intensified sampling, NHP CMVs from TNP are completely host-specific, pinpointing the absence or rarity of cross-species transmission. We also show that on longer timescales the evolution of CMVs is characterized by frequent co-divergence with their hosts, although other processes, including lineage duplication and host switching, also have to be invoked to fully explain their evolutionary relationships. MDPI 2017-12-29 /pmc/articles/PMC5795424/ /pubmed/29286318 http://dx.doi.org/10.3390/v10010011 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Anoh, Augustin Etile
Murthy, Sripriya
Akoua-Koffi, Chantal
Couacy-Hymann, Emmanuel
Leendertz, Fabian Hubertus
Calvignac-Spencer, Sébastien
Ehlers, Bernhard
Cytomegaloviruses in a Community of Wild Nonhuman Primates in Taï National Park, Côte D’Ivoire
title Cytomegaloviruses in a Community of Wild Nonhuman Primates in Taï National Park, Côte D’Ivoire
title_full Cytomegaloviruses in a Community of Wild Nonhuman Primates in Taï National Park, Côte D’Ivoire
title_fullStr Cytomegaloviruses in a Community of Wild Nonhuman Primates in Taï National Park, Côte D’Ivoire
title_full_unstemmed Cytomegaloviruses in a Community of Wild Nonhuman Primates in Taï National Park, Côte D’Ivoire
title_short Cytomegaloviruses in a Community of Wild Nonhuman Primates in Taï National Park, Côte D’Ivoire
title_sort cytomegaloviruses in a community of wild nonhuman primates in taï national park, côte d’ivoire
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795424/
https://www.ncbi.nlm.nih.gov/pubmed/29286318
http://dx.doi.org/10.3390/v10010011
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