Analyses of Tissue Culture Adaptation of Human Herpesvirus-6A by Whole Genome Deep Sequencing Redefines the Reference Sequence and Identifies Virus Entry Complex Changes

Tissue-culture adaptation of viruses can modulate infection. Laboratory passage and bacterial artificial chromosome (BAC)mid cloning of human cytomegalovirus, HCMV, resulted in genomic deletions and rearrangements altering genes encoding the virus entry complex, which affected cellular tropism, viru...

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Detalles Bibliográficos
Autores principales: Tweedy, Joshua G., Escriva, Eric, Topf, Maya, Gompels, Ursula A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795429/
https://www.ncbi.nlm.nih.gov/pubmed/29301233
http://dx.doi.org/10.3390/v10010016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795429/
https://www.ncbi.nlm.nih.gov/pubmed/29301233
http://dx.doi.org/10.3390/v10010016

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