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Viral and Antibody Kinetics, and Mosquito Infectivity of an Imported Case of Zika Fever Due to Asian Genotype (American Strain) in Singapore

We report a case of a Singaporean who acquired Zika virus (ZIKV) during a visit to Cuba. The infection was confirmed using molecular and serological methods. This report highlights potential drawbacks of using IgG serology for diagnosis of flavivirus infections in endemic regions. The low viremia de...

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Autores principales: Tan, Cheong Huat, Tan, Li Kiang, Hapuarachchi, Hapuarachchige Chanditha, Lai, Yee Ling, Wong, Pei Sze Jeslyn, Yap, Grace, Mak, Keng Wai, Wong, Wing Yan, Leo, Yee Sin, Wong, Mei Chun, Ng, Lee Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795457/
https://www.ncbi.nlm.nih.gov/pubmed/29346272
http://dx.doi.org/10.3390/v10010044
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author Tan, Cheong Huat
Tan, Li Kiang
Hapuarachchi, Hapuarachchige Chanditha
Lai, Yee Ling
Wong, Pei Sze Jeslyn
Yap, Grace
Mak, Keng Wai
Wong, Wing Yan
Leo, Yee Sin
Wong, Mei Chun
Ng, Lee Ching
author_facet Tan, Cheong Huat
Tan, Li Kiang
Hapuarachchi, Hapuarachchige Chanditha
Lai, Yee Ling
Wong, Pei Sze Jeslyn
Yap, Grace
Mak, Keng Wai
Wong, Wing Yan
Leo, Yee Sin
Wong, Mei Chun
Ng, Lee Ching
author_sort Tan, Cheong Huat
collection PubMed
description We report a case of a Singaporean who acquired Zika virus (ZIKV) during a visit to Cuba. The infection was confirmed using molecular and serological methods. This report highlights potential drawbacks of using IgG serology for diagnosis of flavivirus infections in endemic regions. The low viremia detected during the early phase of this case resulted in low mosquito infectivity rates, suggesting the possibility of ZIKV transmission prior to clinical onset. The report also emphasizes the challenges of public health interventions for Zika fever and the importance of sustaining a low vector population to reduce the risk of arbovirus transmission in vulnerable regions.
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spelling pubmed-57954572018-02-09 Viral and Antibody Kinetics, and Mosquito Infectivity of an Imported Case of Zika Fever Due to Asian Genotype (American Strain) in Singapore Tan, Cheong Huat Tan, Li Kiang Hapuarachchi, Hapuarachchige Chanditha Lai, Yee Ling Wong, Pei Sze Jeslyn Yap, Grace Mak, Keng Wai Wong, Wing Yan Leo, Yee Sin Wong, Mei Chun Ng, Lee Ching Viruses Case Report We report a case of a Singaporean who acquired Zika virus (ZIKV) during a visit to Cuba. The infection was confirmed using molecular and serological methods. This report highlights potential drawbacks of using IgG serology for diagnosis of flavivirus infections in endemic regions. The low viremia detected during the early phase of this case resulted in low mosquito infectivity rates, suggesting the possibility of ZIKV transmission prior to clinical onset. The report also emphasizes the challenges of public health interventions for Zika fever and the importance of sustaining a low vector population to reduce the risk of arbovirus transmission in vulnerable regions. MDPI 2018-01-18 /pmc/articles/PMC5795457/ /pubmed/29346272 http://dx.doi.org/10.3390/v10010044 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Tan, Cheong Huat
Tan, Li Kiang
Hapuarachchi, Hapuarachchige Chanditha
Lai, Yee Ling
Wong, Pei Sze Jeslyn
Yap, Grace
Mak, Keng Wai
Wong, Wing Yan
Leo, Yee Sin
Wong, Mei Chun
Ng, Lee Ching
Viral and Antibody Kinetics, and Mosquito Infectivity of an Imported Case of Zika Fever Due to Asian Genotype (American Strain) in Singapore
title Viral and Antibody Kinetics, and Mosquito Infectivity of an Imported Case of Zika Fever Due to Asian Genotype (American Strain) in Singapore
title_full Viral and Antibody Kinetics, and Mosquito Infectivity of an Imported Case of Zika Fever Due to Asian Genotype (American Strain) in Singapore
title_fullStr Viral and Antibody Kinetics, and Mosquito Infectivity of an Imported Case of Zika Fever Due to Asian Genotype (American Strain) in Singapore
title_full_unstemmed Viral and Antibody Kinetics, and Mosquito Infectivity of an Imported Case of Zika Fever Due to Asian Genotype (American Strain) in Singapore
title_short Viral and Antibody Kinetics, and Mosquito Infectivity of an Imported Case of Zika Fever Due to Asian Genotype (American Strain) in Singapore
title_sort viral and antibody kinetics, and mosquito infectivity of an imported case of zika fever due to asian genotype (american strain) in singapore
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795457/
https://www.ncbi.nlm.nih.gov/pubmed/29346272
http://dx.doi.org/10.3390/v10010044
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