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Plasticity of the Mre11–Rad50–Xrs2–Sae2 nuclease ensemble in the processing of DNA-bound obstacles

The budding yeast Mre11–Rad50–Xrs2 (MRX) complex and Sae2 function together in DNA end resection during homologous recombination. Here we show that the Ku complex shields DNA ends from exonucleolytic digestion but facilitates endonucleolytic scission by MRX with a dependence on ATP and Sae2. The inc...

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Detalles Bibliográficos
Autores principales:	Wang, Weibin, Daley, James M., Kwon, Youngho, Krasner, Danielle S., Sung, Patrick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2017
Materias:	Research Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795780/ https://www.ncbi.nlm.nih.gov/pubmed/29321177 http://dx.doi.org/10.1101/gad.307900.117

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