Cargando…
Opposing roles of TGFβ and BMP signaling in prostate cancer development
SMAD4 constrains progression of Pten-null prostate cancer and serves as a common downstream node of transforming growth factor β (TGFβ) and bone morphogenetic protein (BMP) pathways. Here, we dissected the roles of TGFβ receptor II (TGFBR2) and BMP receptor II (BMPR2) using a Pten-null prostate canc...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795781/ https://www.ncbi.nlm.nih.gov/pubmed/29352019 http://dx.doi.org/10.1101/gad.307116.117 |
_version_ | 1783297363293503488 |
---|---|
author | Lu, Xin Jin, Eun-Jung Cheng, Xi Feng, Shan Shang, Xiaoying Deng, Pingna Jiang, Shan Chang, Qing Rahmy, Sharif Chaudhary, Seema Lu, Xuemin Zhao, Ren Wang, Y. Alan DePinho, Ronald A. |
author_facet | Lu, Xin Jin, Eun-Jung Cheng, Xi Feng, Shan Shang, Xiaoying Deng, Pingna Jiang, Shan Chang, Qing Rahmy, Sharif Chaudhary, Seema Lu, Xuemin Zhao, Ren Wang, Y. Alan DePinho, Ronald A. |
author_sort | Lu, Xin |
collection | PubMed |
description | SMAD4 constrains progression of Pten-null prostate cancer and serves as a common downstream node of transforming growth factor β (TGFβ) and bone morphogenetic protein (BMP) pathways. Here, we dissected the roles of TGFβ receptor II (TGFBR2) and BMP receptor II (BMPR2) using a Pten-null prostate cancer model. These studies demonstrated that the molecular actions of TGFBR2 result in both SMAD4-dependent constraint of proliferation and SMAD4-independent activation of apoptosis. In contrast, BMPR2 deletion extended survival relative to Pten deletion alone, establishing its promoting role in BMP6-driven prostate cancer progression. These analyses reveal the complexity of TGFβ–BMP signaling and illuminate potential therapeutic targets for prostate cancer. |
format | Online Article Text |
id | pubmed-5795781 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-57957812018-06-01 Opposing roles of TGFβ and BMP signaling in prostate cancer development Lu, Xin Jin, Eun-Jung Cheng, Xi Feng, Shan Shang, Xiaoying Deng, Pingna Jiang, Shan Chang, Qing Rahmy, Sharif Chaudhary, Seema Lu, Xuemin Zhao, Ren Wang, Y. Alan DePinho, Ronald A. Genes Dev Research Communication SMAD4 constrains progression of Pten-null prostate cancer and serves as a common downstream node of transforming growth factor β (TGFβ) and bone morphogenetic protein (BMP) pathways. Here, we dissected the roles of TGFβ receptor II (TGFBR2) and BMP receptor II (BMPR2) using a Pten-null prostate cancer model. These studies demonstrated that the molecular actions of TGFBR2 result in both SMAD4-dependent constraint of proliferation and SMAD4-independent activation of apoptosis. In contrast, BMPR2 deletion extended survival relative to Pten deletion alone, establishing its promoting role in BMP6-driven prostate cancer progression. These analyses reveal the complexity of TGFβ–BMP signaling and illuminate potential therapeutic targets for prostate cancer. Cold Spring Harbor Laboratory Press 2017-12-01 /pmc/articles/PMC5795781/ /pubmed/29352019 http://dx.doi.org/10.1101/gad.307116.117 Text en © 2018 Lu et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Research Communication Lu, Xin Jin, Eun-Jung Cheng, Xi Feng, Shan Shang, Xiaoying Deng, Pingna Jiang, Shan Chang, Qing Rahmy, Sharif Chaudhary, Seema Lu, Xuemin Zhao, Ren Wang, Y. Alan DePinho, Ronald A. Opposing roles of TGFβ and BMP signaling in prostate cancer development |
title | Opposing roles of TGFβ and BMP signaling in prostate cancer development |
title_full | Opposing roles of TGFβ and BMP signaling in prostate cancer development |
title_fullStr | Opposing roles of TGFβ and BMP signaling in prostate cancer development |
title_full_unstemmed | Opposing roles of TGFβ and BMP signaling in prostate cancer development |
title_short | Opposing roles of TGFβ and BMP signaling in prostate cancer development |
title_sort | opposing roles of tgfβ and bmp signaling in prostate cancer development |
topic | Research Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795781/ https://www.ncbi.nlm.nih.gov/pubmed/29352019 http://dx.doi.org/10.1101/gad.307116.117 |
work_keys_str_mv | AT luxin opposingrolesoftgfbandbmpsignalinginprostatecancerdevelopment AT jineunjung opposingrolesoftgfbandbmpsignalinginprostatecancerdevelopment AT chengxi opposingrolesoftgfbandbmpsignalinginprostatecancerdevelopment AT fengshan opposingrolesoftgfbandbmpsignalinginprostatecancerdevelopment AT shangxiaoying opposingrolesoftgfbandbmpsignalinginprostatecancerdevelopment AT dengpingna opposingrolesoftgfbandbmpsignalinginprostatecancerdevelopment AT jiangshan opposingrolesoftgfbandbmpsignalinginprostatecancerdevelopment AT changqing opposingrolesoftgfbandbmpsignalinginprostatecancerdevelopment AT rahmysharif opposingrolesoftgfbandbmpsignalinginprostatecancerdevelopment AT chaudharyseema opposingrolesoftgfbandbmpsignalinginprostatecancerdevelopment AT luxuemin opposingrolesoftgfbandbmpsignalinginprostatecancerdevelopment AT zhaoren opposingrolesoftgfbandbmpsignalinginprostatecancerdevelopment AT wangyalan opposingrolesoftgfbandbmpsignalinginprostatecancerdevelopment AT depinhoronalda opposingrolesoftgfbandbmpsignalinginprostatecancerdevelopment |