Cargando…

Minoxidil Induction of VEGF Is Mediated by Inhibition of HIF-Prolyl Hydroxylase

The topical application of minoxidil may achieve millimolar concentrations in the skin. We investigated whether millimolar minoxidil could induce vascular endothelial growth factor (VEGF), a possible effector for minoxidil-mediated hair growth, and how it occurred at the molecular level. Cell-based...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yum, Soohwan, Jeong, Seongkeun, Kim, Dohoon, Lee, Sunyoung, Kim, Wooseong, Yoo, Jin-Wook, Kim, Jung-Ae, Kwon, Oh Sang, Kim, Dae-Duk, Min, Do Sik, Jung, Yunjin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796003/ https://www.ncbi.nlm.nih.gov/pubmed/29295567 http://dx.doi.org/10.3390/ijms19010053

Ejemplares similares

Phospholipase D activates HIF-1-VEGF pathway via phosphatidic acid
por: Han, Songyi, et al.
Publicado: (2014)

Colon-targeted delivery of piceatannol enhances anti-colitic effects of the natural product: potential molecular mechanisms for therapeutic enhancement
por: Yum, Soohwan, et al.
Publicado: (2015)

Conjugation of metronidazole with dextran: a potential pharmaceutical strategy to control colonic distribution of the anti-amebic drug susceptible to metabolism by colonic microbes
por: Kim, Wooseong, et al.
Publicado: (2017)

The role of HIF prolyl hydroxylases in tumour growth
por: Jokilehto, Terhi, et al.
Publicado: (2010)

Celecoxib coupled to dextran via a glutamic acid linker yields a polymeric prodrug suitable for colonic delivery
por: Lee, Yonghyun, et al.
Publicado: (2015)

A colon-specific prodrug of metoclopramide ameliorates colitis in an experimental rat model
por: Yang, Yejin, et al.
Publicado: (2018)

Microbiota-derived butyrate is an endogenous HIF prolyl hydroxylase inhibitor
por: Wang, Ruth X., et al.
Publicado: (2021)

Inhibition of HIF-prolyl hydroxylases improves healing of intestinal anastomoses
por: Strowitzki, Moritz J., et al.
Publicado: (2021)

Role of prolyl hydroxylase/HIF-1 signaling in vascular calcification
por: Negri, Armando Luis
Publicado: (2022)

Evaluation of glycine-bearing celecoxib derivatives as a colon-specific mutual prodrug acting on nuclear factor-κB, an anti-inflammatory target
por: Lee, Sunyoung, et al.
Publicado: (2015)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
por: Cockman, Matthew E, et al.
Publicado: (2019)

HIF-independent role of prolyl hydroxylases in the cellular response to amino acids
por: Durán, R V, et al.
Publicado: (2013)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
por: Chowdhury, Rasheduzzaman, et al.
Publicado: (2016)

Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials
por: Yeh, Tzu-Lan, et al.
Publicado: (2017)

Neuroprotective Effect of HIF Prolyl Hydroxylase Inhibition in an In Vitro Hypoxia Model
por: Savyuk, Maria, et al.
Publicado: (2020)

HIF Prolyl Hydroxylase Inhibitors for COVID-19 Treatment: Pros and Cons
por: Poloznikov, Andrey A., et al.
Publicado: (2021)

Precisely Tuned Inhibition of HIF Prolyl Hydroxylases Is Key for Cardioprotection After Ischemia
por: Jatho, Aline, et al.
Publicado: (2021)

HIF-α Prolyl Hydroxylase Inhibitors and Their Implications for Biomedicine: A Comprehensive Review
por: Hirota, Kiichi
Publicado: (2021)

The HIF-prolyl hydroxylases have distinct and nonredundant roles in colitis-associated cancer
por: Kennel, Kilian B., et al.
Publicado: (2022)

Novel Dioxygenases, HIF-α Specific Prolyl-hydroxylase and Asparanginyl-hydroxylase: O(2) Switch for Cell Survival
por: Park, Hyunsung
Publicado: (2008)

Conjugation of Amisulpride, an Anti-Psychotic Agent, with 5-Aminosalicylic Acid via an Azo Bond Yields an Orally Active Mutual Prodrug against Rat Colitis
por: Kim, Wooseong, et al.
Publicado: (2019)

Evolving Strategies in the Treatment of Anaemia in Chronic Kidney Disease: The HIF-Prolyl Hydroxylase Inhibitors
por: Locatelli, Francesco, et al.
Publicado: (2022)

No benefit of HIF prolyl hydroxylase inhibition for hypertensive renal damage in renovascular hypertensive rats
por: Hartner, Andrea, et al.
Publicado: (2023)

miR-190 Enhances HIF-Dependent Responses to Hypoxia in Drosophila by Inhibiting the Prolyl-4-hydroxylase Fatiga
por: De Lella Ezcurra, Ana Laura, et al.
Publicado: (2016)

Effect of Proline Analogues on Activity of Human Prolyl Hydroxylase and the Regulation of HIF Signal Transduction Pathway
por: Ma, Xiaoyan, et al.
Publicado: (2014)

Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases
por: Chan, Mun Chiang, et al.
Publicado: (2016)

HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury
por: Billin, Andrew N., et al.
Publicado: (2018)

Collagen prolyl 4-hydroxylase 1 is essential for HIF-1α stabilization and TNBC chemoresistance
por: Xiong, Gaofeng, et al.
Publicado: (2018)

Structure‐Activity Relationship and Crystallographic Studies on 4‐Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors
por: Holt‐Martyn, James P., et al.
Publicado: (2019)

Zinc Inhibits HIF-Prolyl Hydroxylase Inhibitor-Aggravated VSMC Calcification Induced by High Phosphate
por: Nagy, Annamária, et al.
Publicado: (2020)

HIF-Prolyl Hydroxylase Domain Proteins (PHDs) in Cancer—Potential Targets for Anti-Tumor Therapy?
por: Gaete, Diana, et al.
Publicado: (2021)

Prolyl hydroxylase-3 is a novel renal cell carcinoma biomarker
por: Kim, Kwang Hyun, et al.
Publicado: (2019)

Correction to: HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction induced injury
por: Billin, Andrew N., et al.
Publicado: (2018)

Vadadustat, a HIF Prolyl Hydroxylase Inhibitor, Improves Immunomodulatory Properties of Human Mesenchymal Stromal Cells
por: Zielniok, Katarzyna, et al.
Publicado: (2020)

HIF-α activation by the prolyl hydroxylase inhibitor roxadustat suppresses chemoresistant glioblastoma growth by inducing ferroptosis
por: Su, Xiaodong, et al.
Publicado: (2022)

Post-ischemic inactivation of HIF prolyl hydroxylases in endothelium promotes maladaptive kidney repair by inducing glycolysis
por: Tiwari, Ratnakar, et al.
Publicado: (2023)

Prolyl hydroxylase domain protein 3 and asparaginyl hydroxylase factor inhibiting HIF-1 levels are predictive of tumoral behavior and prognosis in hepatocellular carcinoma
por: Ma, Mingyang, et al.
Publicado: (2017)

Involvement of Prolyl Hydroxylase Domain Protein in the Rosiglitazone-Induced Suppression of Osteoblast Differentiation
por: Kang, Ju-Hee, et al.
Publicado: (2015)

Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility
por: Astuti, Dewi, et al.
Publicado: (2011)

Gingerol prevents prion protein-mediated neuronal toxicity by regulating HIF prolyl hydroxylase 2 and prion protein
por: PARK, YANG-GYU, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_m8s7jak2uo51dg0iu9oi6j4gjk