Structure and Molecular Dynamics Simulations of Protein Tyrosine Phosphatase Non-Receptor 12 Provide Insights into the Catalytic Mechanism of the Enzyme

Protein tyrosine phosphatase non-receptor 12 (PTPN12) is an important protein tyrosine phosphatase involved in regulating cell adhesion and migration as well as tumorigenesis. Here, we solved a crystal structure of the native PTPN12 catalytic domain with the catalytic cysteine (residue 231) in dual...

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Detalles Bibliográficos
Autores principales: Dong, Hui, Zonta, Francesco, Wang, Shanshan, Song, Ke, He, Xin, He, Miaomiao, Nie, Yan, Li, Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796010/
https://www.ncbi.nlm.nih.gov/pubmed/29278368
http://dx.doi.org/10.3390/ijms19010060

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