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Natural Antisense Transcripts: Molecular Mechanisms and Implications in Breast Cancers

Natural antisense transcripts are RNA sequences that can be transcribed from both DNA strands at the same locus but in the opposite direction from the gene transcript. Because strand-specific high-throughput sequencing of the antisense transcriptome has only been available for less than a decade, ma...

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Detalles Bibliográficos
Autores principales: Latgé, Guillaume, Poulet, Christophe, Bours, Vincent, Josse, Claire, Jerusalem, Guy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796072/
https://www.ncbi.nlm.nih.gov/pubmed/29301303
http://dx.doi.org/10.3390/ijms19010123
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author Latgé, Guillaume
Poulet, Christophe
Bours, Vincent
Josse, Claire
Jerusalem, Guy
author_facet Latgé, Guillaume
Poulet, Christophe
Bours, Vincent
Josse, Claire
Jerusalem, Guy
author_sort Latgé, Guillaume
collection PubMed
description Natural antisense transcripts are RNA sequences that can be transcribed from both DNA strands at the same locus but in the opposite direction from the gene transcript. Because strand-specific high-throughput sequencing of the antisense transcriptome has only been available for less than a decade, many natural antisense transcripts were first described as long non-coding RNAs. Although the precise biological roles of natural antisense transcripts are not known yet, an increasing number of studies report their implication in gene expression regulation. Their expression levels are altered in many physiological and pathological conditions, including breast cancers. Among the potential clinical utilities of the natural antisense transcripts, the non-coding|coding transcript pairs are of high interest for treatment. Indeed, these pairs can be targeted by antisense oligonucleotides to specifically tune the expression of the coding-gene. Here, we describe the current knowledge about natural antisense transcripts, their varying molecular mechanisms as gene expression regulators, and their potential as prognostic or predictive biomarkers in breast cancers.
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spelling pubmed-57960722018-02-09 Natural Antisense Transcripts: Molecular Mechanisms and Implications in Breast Cancers Latgé, Guillaume Poulet, Christophe Bours, Vincent Josse, Claire Jerusalem, Guy Int J Mol Sci Review Natural antisense transcripts are RNA sequences that can be transcribed from both DNA strands at the same locus but in the opposite direction from the gene transcript. Because strand-specific high-throughput sequencing of the antisense transcriptome has only been available for less than a decade, many natural antisense transcripts were first described as long non-coding RNAs. Although the precise biological roles of natural antisense transcripts are not known yet, an increasing number of studies report their implication in gene expression regulation. Their expression levels are altered in many physiological and pathological conditions, including breast cancers. Among the potential clinical utilities of the natural antisense transcripts, the non-coding|coding transcript pairs are of high interest for treatment. Indeed, these pairs can be targeted by antisense oligonucleotides to specifically tune the expression of the coding-gene. Here, we describe the current knowledge about natural antisense transcripts, their varying molecular mechanisms as gene expression regulators, and their potential as prognostic or predictive biomarkers in breast cancers. MDPI 2018-01-02 /pmc/articles/PMC5796072/ /pubmed/29301303 http://dx.doi.org/10.3390/ijms19010123 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Latgé, Guillaume
Poulet, Christophe
Bours, Vincent
Josse, Claire
Jerusalem, Guy
Natural Antisense Transcripts: Molecular Mechanisms and Implications in Breast Cancers
title Natural Antisense Transcripts: Molecular Mechanisms and Implications in Breast Cancers
title_full Natural Antisense Transcripts: Molecular Mechanisms and Implications in Breast Cancers
title_fullStr Natural Antisense Transcripts: Molecular Mechanisms and Implications in Breast Cancers
title_full_unstemmed Natural Antisense Transcripts: Molecular Mechanisms and Implications in Breast Cancers
title_short Natural Antisense Transcripts: Molecular Mechanisms and Implications in Breast Cancers
title_sort natural antisense transcripts: molecular mechanisms and implications in breast cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796072/
https://www.ncbi.nlm.nih.gov/pubmed/29301303
http://dx.doi.org/10.3390/ijms19010123
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