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Understanding the Progression of Bone Metastases to Identify Novel Therapeutic Targets
Bone is one of the most preferential target site for cancer metastases, particularly for prostate, breast, kidney, lung and thyroid primary tumours. Indeed, numerous chemical signals and growth factors produced by the bone microenvironment constitute factors promoting cancer cell invasion and aggres...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796097/ https://www.ncbi.nlm.nih.gov/pubmed/29300334 http://dx.doi.org/10.3390/ijms19010148 |
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author | Schmid-Alliana, Annie Schmid-Antomarchi, Heidy Al-Sahlanee, Rasha Lagadec, Patricia Scimeca, Jean-Claude Verron, Elise |
author_facet | Schmid-Alliana, Annie Schmid-Antomarchi, Heidy Al-Sahlanee, Rasha Lagadec, Patricia Scimeca, Jean-Claude Verron, Elise |
author_sort | Schmid-Alliana, Annie |
collection | PubMed |
description | Bone is one of the most preferential target site for cancer metastases, particularly for prostate, breast, kidney, lung and thyroid primary tumours. Indeed, numerous chemical signals and growth factors produced by the bone microenvironment constitute factors promoting cancer cell invasion and aggression. After reviewing the different theories proposed to provide mechanism for metastatic progression, we report on the gene expression profile of bone-seeking cancer cells. We also discuss the cross-talk between the bone microenvironment and invading cells, which impacts on the tumour actions on surrounding bone tissue. Lastly, we detail therapies for bone metastases. Due to poor prognosis for patients, the strategies mainly aim at reducing the impact of skeletal-related events on patients’ quality of life. However, recent advances have led to a better understanding of molecular mechanisms underlying bone metastases progression, and therefore of novel therapeutic targets. |
format | Online Article Text |
id | pubmed-5796097 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-57960972018-02-09 Understanding the Progression of Bone Metastases to Identify Novel Therapeutic Targets Schmid-Alliana, Annie Schmid-Antomarchi, Heidy Al-Sahlanee, Rasha Lagadec, Patricia Scimeca, Jean-Claude Verron, Elise Int J Mol Sci Review Bone is one of the most preferential target site for cancer metastases, particularly for prostate, breast, kidney, lung and thyroid primary tumours. Indeed, numerous chemical signals and growth factors produced by the bone microenvironment constitute factors promoting cancer cell invasion and aggression. After reviewing the different theories proposed to provide mechanism for metastatic progression, we report on the gene expression profile of bone-seeking cancer cells. We also discuss the cross-talk between the bone microenvironment and invading cells, which impacts on the tumour actions on surrounding bone tissue. Lastly, we detail therapies for bone metastases. Due to poor prognosis for patients, the strategies mainly aim at reducing the impact of skeletal-related events on patients’ quality of life. However, recent advances have led to a better understanding of molecular mechanisms underlying bone metastases progression, and therefore of novel therapeutic targets. MDPI 2018-01-04 /pmc/articles/PMC5796097/ /pubmed/29300334 http://dx.doi.org/10.3390/ijms19010148 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Schmid-Alliana, Annie Schmid-Antomarchi, Heidy Al-Sahlanee, Rasha Lagadec, Patricia Scimeca, Jean-Claude Verron, Elise Understanding the Progression of Bone Metastases to Identify Novel Therapeutic Targets |
title | Understanding the Progression of Bone Metastases to Identify Novel Therapeutic Targets |
title_full | Understanding the Progression of Bone Metastases to Identify Novel Therapeutic Targets |
title_fullStr | Understanding the Progression of Bone Metastases to Identify Novel Therapeutic Targets |
title_full_unstemmed | Understanding the Progression of Bone Metastases to Identify Novel Therapeutic Targets |
title_short | Understanding the Progression of Bone Metastases to Identify Novel Therapeutic Targets |
title_sort | understanding the progression of bone metastases to identify novel therapeutic targets |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796097/ https://www.ncbi.nlm.nih.gov/pubmed/29300334 http://dx.doi.org/10.3390/ijms19010148 |
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