Cargando…

Understanding the Role of Intrinsic Disorder of Viral Proteins in the Oncogenicity of Different Types of HPV

Intrinsic disorder is very important in the biological function of several proteins, and is directly linked to their foldability during interaction with their targets. There is a close relationship between the intrinsically disordered proteins and the process of carcinogenesis involving viral pathog...

Descripción completa

Detalles Bibliográficos
Autores principales: Tamarozzi, Elvira Regina, Giuliatti, Silvana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796147/
https://www.ncbi.nlm.nih.gov/pubmed/29315236
http://dx.doi.org/10.3390/ijms19010198
_version_ 1783297444044341248
author Tamarozzi, Elvira Regina
Giuliatti, Silvana
author_facet Tamarozzi, Elvira Regina
Giuliatti, Silvana
author_sort Tamarozzi, Elvira Regina
collection PubMed
description Intrinsic disorder is very important in the biological function of several proteins, and is directly linked to their foldability during interaction with their targets. There is a close relationship between the intrinsically disordered proteins and the process of carcinogenesis involving viral pathogens. Among these pathogens, we have highlighted the human papillomavirus (HPV) in this study. HPV is currently among the most common sexually transmitted infections, besides being the cause of several types of cancer. HPVs are divided into two groups, called high- and low-risk, based on their oncogenic potential. The high-risk HPV E6 protein has been the target of much research, in seeking treatments against HPV, due to its direct involvement in the process of cell cycle control. To understand the role of intrinsic disorder of the viral proteins in the oncogenic potential of different HPV types, the structural characteristics of intrinsically disordered regions of high and low-risk HPV E6 proteins were analyzed. In silico analyses of primary sequences, prediction of tertiary structures, and analyses of molecular dynamics allowed the observation of the behavior of such disordered regions in these proteins, thereby proving a direct relationship of structural variation with the degree of oncogenicity of HPVs. The results obtained may contribute to the development of new therapies, targeting the E6 oncoprotein, for the treatment of HPV-associated diseases.
format Online
Article
Text
id pubmed-5796147
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-57961472018-02-09 Understanding the Role of Intrinsic Disorder of Viral Proteins in the Oncogenicity of Different Types of HPV Tamarozzi, Elvira Regina Giuliatti, Silvana Int J Mol Sci Article Intrinsic disorder is very important in the biological function of several proteins, and is directly linked to their foldability during interaction with their targets. There is a close relationship between the intrinsically disordered proteins and the process of carcinogenesis involving viral pathogens. Among these pathogens, we have highlighted the human papillomavirus (HPV) in this study. HPV is currently among the most common sexually transmitted infections, besides being the cause of several types of cancer. HPVs are divided into two groups, called high- and low-risk, based on their oncogenic potential. The high-risk HPV E6 protein has been the target of much research, in seeking treatments against HPV, due to its direct involvement in the process of cell cycle control. To understand the role of intrinsic disorder of the viral proteins in the oncogenic potential of different HPV types, the structural characteristics of intrinsically disordered regions of high and low-risk HPV E6 proteins were analyzed. In silico analyses of primary sequences, prediction of tertiary structures, and analyses of molecular dynamics allowed the observation of the behavior of such disordered regions in these proteins, thereby proving a direct relationship of structural variation with the degree of oncogenicity of HPVs. The results obtained may contribute to the development of new therapies, targeting the E6 oncoprotein, for the treatment of HPV-associated diseases. MDPI 2018-01-09 /pmc/articles/PMC5796147/ /pubmed/29315236 http://dx.doi.org/10.3390/ijms19010198 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tamarozzi, Elvira Regina
Giuliatti, Silvana
Understanding the Role of Intrinsic Disorder of Viral Proteins in the Oncogenicity of Different Types of HPV
title Understanding the Role of Intrinsic Disorder of Viral Proteins in the Oncogenicity of Different Types of HPV
title_full Understanding the Role of Intrinsic Disorder of Viral Proteins in the Oncogenicity of Different Types of HPV
title_fullStr Understanding the Role of Intrinsic Disorder of Viral Proteins in the Oncogenicity of Different Types of HPV
title_full_unstemmed Understanding the Role of Intrinsic Disorder of Viral Proteins in the Oncogenicity of Different Types of HPV
title_short Understanding the Role of Intrinsic Disorder of Viral Proteins in the Oncogenicity of Different Types of HPV
title_sort understanding the role of intrinsic disorder of viral proteins in the oncogenicity of different types of hpv
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796147/
https://www.ncbi.nlm.nih.gov/pubmed/29315236
http://dx.doi.org/10.3390/ijms19010198
work_keys_str_mv AT tamarozzielviraregina understandingtheroleofintrinsicdisorderofviralproteinsintheoncogenicityofdifferenttypesofhpv
AT giuliattisilvana understandingtheroleofintrinsicdisorderofviralproteinsintheoncogenicityofdifferenttypesofhpv