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In Vitro Antitumor Activity of Aloperine on Human Thyroid Cancer Cells through Caspase-Dependent Apoptosis

The global incidence of thyroid cancer, one of the most common endocrine malignancies, is especially high among women. Although most patients with thyroid cancers exhibit a good prognosis with standard treatment, there are no effective therapies for patients with anaplastic thyroid cancers or cancer...

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Autores principales: Lee, Ying-Ray, Chen, Shu-Hsin, Lin, Ching-Yen, Chao, Wen-Ying, Lim, Yun-Ping, Yu, Hui-I, Lu, Chieh-Hsiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796256/
https://www.ncbi.nlm.nih.gov/pubmed/29361731
http://dx.doi.org/10.3390/ijms19010312
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author Lee, Ying-Ray
Chen, Shu-Hsin
Lin, Ching-Yen
Chao, Wen-Ying
Lim, Yun-Ping
Yu, Hui-I
Lu, Chieh-Hsiang
author_facet Lee, Ying-Ray
Chen, Shu-Hsin
Lin, Ching-Yen
Chao, Wen-Ying
Lim, Yun-Ping
Yu, Hui-I
Lu, Chieh-Hsiang
author_sort Lee, Ying-Ray
collection PubMed
description The global incidence of thyroid cancer, one of the most common endocrine malignancies, is especially high among women. Although most patients with thyroid cancers exhibit a good prognosis with standard treatment, there are no effective therapies for patients with anaplastic thyroid cancers or cancers that have reached an advanced or recurrent level. Therefore, it is important to develop highly effective compounds for treating such patients. Aloperine, a natural compound isolated from Sophora alopecuroides, has been reported to possess antioxidant, anti-inflammatory, anti-neuronal injury, anti-renal injury, antitumor, anti-allergic, and antiviral properties. In this study, we show that aloperine can inhibit cell growth in human anaplastic thyroid cancers and multidrug-resistant papillary thyroid cancers. Moreover, it could suppress in vitro tumorigenesis and promote cellular apoptosis. Further analysis demonstrated the involvement of caspase-dependent apoptosis, including intrinsic and/or extrinsic pathways, in aloperine-induced cellular apoptosis. However, cell cycle regulation was not detected with aloperine treatment. This study suggests the potential therapeutic use of aloperine in human anaplastic thyroid cancers and multidrug-resistant papillary thyroid cancers.
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spelling pubmed-57962562018-02-09 In Vitro Antitumor Activity of Aloperine on Human Thyroid Cancer Cells through Caspase-Dependent Apoptosis Lee, Ying-Ray Chen, Shu-Hsin Lin, Ching-Yen Chao, Wen-Ying Lim, Yun-Ping Yu, Hui-I Lu, Chieh-Hsiang Int J Mol Sci Article The global incidence of thyroid cancer, one of the most common endocrine malignancies, is especially high among women. Although most patients with thyroid cancers exhibit a good prognosis with standard treatment, there are no effective therapies for patients with anaplastic thyroid cancers or cancers that have reached an advanced or recurrent level. Therefore, it is important to develop highly effective compounds for treating such patients. Aloperine, a natural compound isolated from Sophora alopecuroides, has been reported to possess antioxidant, anti-inflammatory, anti-neuronal injury, anti-renal injury, antitumor, anti-allergic, and antiviral properties. In this study, we show that aloperine can inhibit cell growth in human anaplastic thyroid cancers and multidrug-resistant papillary thyroid cancers. Moreover, it could suppress in vitro tumorigenesis and promote cellular apoptosis. Further analysis demonstrated the involvement of caspase-dependent apoptosis, including intrinsic and/or extrinsic pathways, in aloperine-induced cellular apoptosis. However, cell cycle regulation was not detected with aloperine treatment. This study suggests the potential therapeutic use of aloperine in human anaplastic thyroid cancers and multidrug-resistant papillary thyroid cancers. MDPI 2018-01-21 /pmc/articles/PMC5796256/ /pubmed/29361731 http://dx.doi.org/10.3390/ijms19010312 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Ying-Ray
Chen, Shu-Hsin
Lin, Ching-Yen
Chao, Wen-Ying
Lim, Yun-Ping
Yu, Hui-I
Lu, Chieh-Hsiang
In Vitro Antitumor Activity of Aloperine on Human Thyroid Cancer Cells through Caspase-Dependent Apoptosis
title In Vitro Antitumor Activity of Aloperine on Human Thyroid Cancer Cells through Caspase-Dependent Apoptosis
title_full In Vitro Antitumor Activity of Aloperine on Human Thyroid Cancer Cells through Caspase-Dependent Apoptosis
title_fullStr In Vitro Antitumor Activity of Aloperine on Human Thyroid Cancer Cells through Caspase-Dependent Apoptosis
title_full_unstemmed In Vitro Antitumor Activity of Aloperine on Human Thyroid Cancer Cells through Caspase-Dependent Apoptosis
title_short In Vitro Antitumor Activity of Aloperine on Human Thyroid Cancer Cells through Caspase-Dependent Apoptosis
title_sort in vitro antitumor activity of aloperine on human thyroid cancer cells through caspase-dependent apoptosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796256/
https://www.ncbi.nlm.nih.gov/pubmed/29361731
http://dx.doi.org/10.3390/ijms19010312
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