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Overall Survival of Ovarian Cancer Patients Is Determined by Expression of Galectins-8 and -9

The evaluation of new prognostic factors that can be targeted in ovarian cancer diagnosis and therapy is of the utmost importance. Galectins are a family of carbohydrate binding proteins with various implications in cancer biology. In this study, the presence of galectin (Gal)-8 and -9 was investiga...

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Detalles Bibliográficos
Autores principales: Schulz, Heiko, Kuhn, Christina, Hofmann, Simone, Mayr, Doris, Mahner, Sven, Jeschke, Udo, Schmoeckel, Elisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796266/
https://www.ncbi.nlm.nih.gov/pubmed/29361803
http://dx.doi.org/10.3390/ijms19010323
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author Schulz, Heiko
Kuhn, Christina
Hofmann, Simone
Mayr, Doris
Mahner, Sven
Jeschke, Udo
Schmoeckel, Elisa
author_facet Schulz, Heiko
Kuhn, Christina
Hofmann, Simone
Mayr, Doris
Mahner, Sven
Jeschke, Udo
Schmoeckel, Elisa
author_sort Schulz, Heiko
collection PubMed
description The evaluation of new prognostic factors that can be targeted in ovarian cancer diagnosis and therapy is of the utmost importance. Galectins are a family of carbohydrate binding proteins with various implications in cancer biology. In this study, the presence of galectin (Gal)-8 and -9 was investigated in 156 ovarian cancer samples using immunohistochemistry (IHC). Staining was evaluated using semi-quantitative immunoreactivity (IR) scores and correlated to clinical and pathological data. Different types of galectin expression were compared with respect to disease-free survival (DFS) and overall survival (OS). Gal-8 served as a new positive prognostic factor for the OS and DFS of ovarian cancer patients. Gal-9 expression determined the DFS and OS of ovarian cancer patients in two opposing ways—moderate Gal-9 expression was correlated with a reduced outcome as compared to Gal-9 negative cases, while patients with high Gal-9 expression showed the best outcome.
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spelling pubmed-57962662018-02-09 Overall Survival of Ovarian Cancer Patients Is Determined by Expression of Galectins-8 and -9 Schulz, Heiko Kuhn, Christina Hofmann, Simone Mayr, Doris Mahner, Sven Jeschke, Udo Schmoeckel, Elisa Int J Mol Sci Article The evaluation of new prognostic factors that can be targeted in ovarian cancer diagnosis and therapy is of the utmost importance. Galectins are a family of carbohydrate binding proteins with various implications in cancer biology. In this study, the presence of galectin (Gal)-8 and -9 was investigated in 156 ovarian cancer samples using immunohistochemistry (IHC). Staining was evaluated using semi-quantitative immunoreactivity (IR) scores and correlated to clinical and pathological data. Different types of galectin expression were compared with respect to disease-free survival (DFS) and overall survival (OS). Gal-8 served as a new positive prognostic factor for the OS and DFS of ovarian cancer patients. Gal-9 expression determined the DFS and OS of ovarian cancer patients in two opposing ways—moderate Gal-9 expression was correlated with a reduced outcome as compared to Gal-9 negative cases, while patients with high Gal-9 expression showed the best outcome. MDPI 2018-01-22 /pmc/articles/PMC5796266/ /pubmed/29361803 http://dx.doi.org/10.3390/ijms19010323 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Schulz, Heiko
Kuhn, Christina
Hofmann, Simone
Mayr, Doris
Mahner, Sven
Jeschke, Udo
Schmoeckel, Elisa
Overall Survival of Ovarian Cancer Patients Is Determined by Expression of Galectins-8 and -9
title Overall Survival of Ovarian Cancer Patients Is Determined by Expression of Galectins-8 and -9
title_full Overall Survival of Ovarian Cancer Patients Is Determined by Expression of Galectins-8 and -9
title_fullStr Overall Survival of Ovarian Cancer Patients Is Determined by Expression of Galectins-8 and -9
title_full_unstemmed Overall Survival of Ovarian Cancer Patients Is Determined by Expression of Galectins-8 and -9
title_short Overall Survival of Ovarian Cancer Patients Is Determined by Expression of Galectins-8 and -9
title_sort overall survival of ovarian cancer patients is determined by expression of galectins-8 and -9
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796266/
https://www.ncbi.nlm.nih.gov/pubmed/29361803
http://dx.doi.org/10.3390/ijms19010323
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