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Therapeutic targeting of noncoding RNAs in hepatocellular carcinoma: Recent progress and future prospects

Due to the high mortality rate and unsatisfactory treatment options available, hepatocellular carcinoma (HCC) remains one of the most common malignancies and a leading cause of cancer-associated mortality. Novel therapeutic targets for HCC are urgently required. Advanced RNA sequencing technology en...

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Detalles Bibliográficos
Autores principales: Xiao, Zhangang, Shen, Jing, Zhang, Lin, Li, Mingxing, Hu, Wei, Cho, Chihin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796293/
https://www.ncbi.nlm.nih.gov/pubmed/29467864
http://dx.doi.org/10.3892/ol.2018.7758
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author Xiao, Zhangang
Shen, Jing
Zhang, Lin
Li, Mingxing
Hu, Wei
Cho, Chihin
author_facet Xiao, Zhangang
Shen, Jing
Zhang, Lin
Li, Mingxing
Hu, Wei
Cho, Chihin
author_sort Xiao, Zhangang
collection PubMed
description Due to the high mortality rate and unsatisfactory treatment options available, hepatocellular carcinoma (HCC) remains one of the most common malignancies and a leading cause of cancer-associated mortality. Novel therapeutic targets for HCC are urgently required. Advanced RNA sequencing technology enables the identification of considerable amounts of noncoding RNAs (ncRNAs), including small noncoding RNAs and long noncoding RNAs, which exhibit no protein-coding activities. In this respect, ncRNAs and their regulatory processes are important factors in liver tumorigenesis. The present review focuses on the characteristics and biological roles of ncRNAs in HCC. Potential therapeutic applications of ncRNAs in HCC are also evaluated.
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spelling pubmed-57962932018-02-21 Therapeutic targeting of noncoding RNAs in hepatocellular carcinoma: Recent progress and future prospects Xiao, Zhangang Shen, Jing Zhang, Lin Li, Mingxing Hu, Wei Cho, Chihin Oncol Lett Review Due to the high mortality rate and unsatisfactory treatment options available, hepatocellular carcinoma (HCC) remains one of the most common malignancies and a leading cause of cancer-associated mortality. Novel therapeutic targets for HCC are urgently required. Advanced RNA sequencing technology enables the identification of considerable amounts of noncoding RNAs (ncRNAs), including small noncoding RNAs and long noncoding RNAs, which exhibit no protein-coding activities. In this respect, ncRNAs and their regulatory processes are important factors in liver tumorigenesis. The present review focuses on the characteristics and biological roles of ncRNAs in HCC. Potential therapeutic applications of ncRNAs in HCC are also evaluated. D.A. Spandidos 2018-03 2018-01-09 /pmc/articles/PMC5796293/ /pubmed/29467864 http://dx.doi.org/10.3892/ol.2018.7758 Text en Copyright: © Xiao et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review
Xiao, Zhangang
Shen, Jing
Zhang, Lin
Li, Mingxing
Hu, Wei
Cho, Chihin
Therapeutic targeting of noncoding RNAs in hepatocellular carcinoma: Recent progress and future prospects
title Therapeutic targeting of noncoding RNAs in hepatocellular carcinoma: Recent progress and future prospects
title_full Therapeutic targeting of noncoding RNAs in hepatocellular carcinoma: Recent progress and future prospects
title_fullStr Therapeutic targeting of noncoding RNAs in hepatocellular carcinoma: Recent progress and future prospects
title_full_unstemmed Therapeutic targeting of noncoding RNAs in hepatocellular carcinoma: Recent progress and future prospects
title_short Therapeutic targeting of noncoding RNAs in hepatocellular carcinoma: Recent progress and future prospects
title_sort therapeutic targeting of noncoding rnas in hepatocellular carcinoma: recent progress and future prospects
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796293/
https://www.ncbi.nlm.nih.gov/pubmed/29467864
http://dx.doi.org/10.3892/ol.2018.7758
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