Hsp90β knockdown in DIO mice reverses insulin resistance and improves glucose tolerance

BACKGROUND: Inhibition of Hsp90 has been shown to improve glucose tolerance and insulin sensitivity in mouse models of diabetes. In the present report, the specific isoform Hsp90ab1, was identified as playing a major role in regulating insulin signaling and glucose metabolism. METHODS: In a diet-ind...

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Detalles Bibliográficos
Autores principales: Jing, Enxuan, Sundararajan, Pragalath, Majumdar, Ishita Deb, Hazarika, Suwagmani, Fowler, Samantha, Szeto, Angela, Gesta, Stephane, Mendez, Armando J., Vishnudas, Vivek K., Sarangarajan, Rangaprasad, Narain, Niven R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796506/
https://www.ncbi.nlm.nih.gov/pubmed/29434648
http://dx.doi.org/10.1186/s12986-018-0242-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796506/
https://www.ncbi.nlm.nih.gov/pubmed/29434648
http://dx.doi.org/10.1186/s12986-018-0242-6

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