A new compound of thiophenylated pyridazinone IMB5043 showing potent antitumor efficacy through ATM-Chk2 pathway

Through cell-based screening models, we have identified a new compound IMB5043, a thiophenylated pyridazinone, which exerted cytotoxicity against cancer cells. In the present study, we evaluated its antitumor efficacy and the possible mechanism. By MTT assay, IMB5043 inhibited the proliferation of v...

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Detalles Bibliográficos
Autores principales: Gong, Jianhua, Zheng, Yanbo, Wang, Ying, Sheng, Weijin, Li, Yi, Liu, Xiujun, Si, Shuyi, Shao, Rongguang, Zhen, Yongsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796703/
https://www.ncbi.nlm.nih.gov/pubmed/29394294
http://dx.doi.org/10.1371/journal.pone.0191984

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