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Choroidal thickness measured using swept-source optical coherence tomography is reduced in patients with type 2 diabetes

OBJECTIVE: To compare choroidal thickness between patients with type 2 diabetes (T2D) and healthy controls measured using swept-source optical coherence tomography (SS-OCT). METHODS: The sample comprised 157 eyes of 94 T2D patients, 48 eyes of which had diabetic macular edema (DME), and 71 normal ey...

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Autores principales: Abadia, Beatriz, Suñen, Ines, Calvo, Pilar, Bartol, Francisco, Verdes, Guayente, Ferreras, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796707/
https://www.ncbi.nlm.nih.gov/pubmed/29394291
http://dx.doi.org/10.1371/journal.pone.0191977
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author Abadia, Beatriz
Suñen, Ines
Calvo, Pilar
Bartol, Francisco
Verdes, Guayente
Ferreras, Antonio
author_facet Abadia, Beatriz
Suñen, Ines
Calvo, Pilar
Bartol, Francisco
Verdes, Guayente
Ferreras, Antonio
author_sort Abadia, Beatriz
collection PubMed
description OBJECTIVE: To compare choroidal thickness between patients with type 2 diabetes (T2D) and healthy controls measured using swept-source optical coherence tomography (SS-OCT). METHODS: The sample comprised 157 eyes of 94 T2D patients, 48 eyes of which had diabetic macular edema (DME), and 71 normal eyes of 38 healthy patients. Subfoveal (SF) choroidal thickness, and choroidal thickness at 500-μm intervals up to 2500 μm nasal and temporal from the fovea were measured using the SS-OCT. Choroidal thicknesses were compared between groups using Student’s t-test. Additionally, Pearson correlations were calculated between diabetes duration, glycosylated hemoglobin (HbA1c) levels, and choroidal thickness. RESULTS: Mean diabetes duration was 16.6±9.5 years, while mean glycosylated hemoglobin was 7.7±1.3%. Overall, the choroid was significantly thinner in T2D patients. Individuals with DME had reduced choroidal thickness in all measurements, except at 2000 and 2500-μm nasal positions, compared to healthy controls. There was a moderate correlation between choroidal thickness and HbA1c levels in DME patients (SF: r = 0.342; p = 0.017). Diabetes duration did not correlate significantly with choroidal thickness. CONCLUSION: SS-OCT measurements revealed that the choroid was significantly thinner in T2D patients, moderate non-proliferative diabetic retinopathy patients, and DME patients than in healthy individuals. Further studies are needed to clarify the effect of diabetes on this layer and the relationship between choroidal thickness and DME.
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spelling pubmed-57967072018-02-16 Choroidal thickness measured using swept-source optical coherence tomography is reduced in patients with type 2 diabetes Abadia, Beatriz Suñen, Ines Calvo, Pilar Bartol, Francisco Verdes, Guayente Ferreras, Antonio PLoS One Research Article OBJECTIVE: To compare choroidal thickness between patients with type 2 diabetes (T2D) and healthy controls measured using swept-source optical coherence tomography (SS-OCT). METHODS: The sample comprised 157 eyes of 94 T2D patients, 48 eyes of which had diabetic macular edema (DME), and 71 normal eyes of 38 healthy patients. Subfoveal (SF) choroidal thickness, and choroidal thickness at 500-μm intervals up to 2500 μm nasal and temporal from the fovea were measured using the SS-OCT. Choroidal thicknesses were compared between groups using Student’s t-test. Additionally, Pearson correlations were calculated between diabetes duration, glycosylated hemoglobin (HbA1c) levels, and choroidal thickness. RESULTS: Mean diabetes duration was 16.6±9.5 years, while mean glycosylated hemoglobin was 7.7±1.3%. Overall, the choroid was significantly thinner in T2D patients. Individuals with DME had reduced choroidal thickness in all measurements, except at 2000 and 2500-μm nasal positions, compared to healthy controls. There was a moderate correlation between choroidal thickness and HbA1c levels in DME patients (SF: r = 0.342; p = 0.017). Diabetes duration did not correlate significantly with choroidal thickness. CONCLUSION: SS-OCT measurements revealed that the choroid was significantly thinner in T2D patients, moderate non-proliferative diabetic retinopathy patients, and DME patients than in healthy individuals. Further studies are needed to clarify the effect of diabetes on this layer and the relationship between choroidal thickness and DME. Public Library of Science 2018-02-02 /pmc/articles/PMC5796707/ /pubmed/29394291 http://dx.doi.org/10.1371/journal.pone.0191977 Text en © 2018 Abadia et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Abadia, Beatriz
Suñen, Ines
Calvo, Pilar
Bartol, Francisco
Verdes, Guayente
Ferreras, Antonio
Choroidal thickness measured using swept-source optical coherence tomography is reduced in patients with type 2 diabetes
title Choroidal thickness measured using swept-source optical coherence tomography is reduced in patients with type 2 diabetes
title_full Choroidal thickness measured using swept-source optical coherence tomography is reduced in patients with type 2 diabetes
title_fullStr Choroidal thickness measured using swept-source optical coherence tomography is reduced in patients with type 2 diabetes
title_full_unstemmed Choroidal thickness measured using swept-source optical coherence tomography is reduced in patients with type 2 diabetes
title_short Choroidal thickness measured using swept-source optical coherence tomography is reduced in patients with type 2 diabetes
title_sort choroidal thickness measured using swept-source optical coherence tomography is reduced in patients with type 2 diabetes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796707/
https://www.ncbi.nlm.nih.gov/pubmed/29394291
http://dx.doi.org/10.1371/journal.pone.0191977
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