Cargando…
Choroidal thickness measured using swept-source optical coherence tomography is reduced in patients with type 2 diabetes
OBJECTIVE: To compare choroidal thickness between patients with type 2 diabetes (T2D) and healthy controls measured using swept-source optical coherence tomography (SS-OCT). METHODS: The sample comprised 157 eyes of 94 T2D patients, 48 eyes of which had diabetic macular edema (DME), and 71 normal ey...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796707/ https://www.ncbi.nlm.nih.gov/pubmed/29394291 http://dx.doi.org/10.1371/journal.pone.0191977 |
_version_ | 1783297546791157760 |
---|---|
author | Abadia, Beatriz Suñen, Ines Calvo, Pilar Bartol, Francisco Verdes, Guayente Ferreras, Antonio |
author_facet | Abadia, Beatriz Suñen, Ines Calvo, Pilar Bartol, Francisco Verdes, Guayente Ferreras, Antonio |
author_sort | Abadia, Beatriz |
collection | PubMed |
description | OBJECTIVE: To compare choroidal thickness between patients with type 2 diabetes (T2D) and healthy controls measured using swept-source optical coherence tomography (SS-OCT). METHODS: The sample comprised 157 eyes of 94 T2D patients, 48 eyes of which had diabetic macular edema (DME), and 71 normal eyes of 38 healthy patients. Subfoveal (SF) choroidal thickness, and choroidal thickness at 500-μm intervals up to 2500 μm nasal and temporal from the fovea were measured using the SS-OCT. Choroidal thicknesses were compared between groups using Student’s t-test. Additionally, Pearson correlations were calculated between diabetes duration, glycosylated hemoglobin (HbA1c) levels, and choroidal thickness. RESULTS: Mean diabetes duration was 16.6±9.5 years, while mean glycosylated hemoglobin was 7.7±1.3%. Overall, the choroid was significantly thinner in T2D patients. Individuals with DME had reduced choroidal thickness in all measurements, except at 2000 and 2500-μm nasal positions, compared to healthy controls. There was a moderate correlation between choroidal thickness and HbA1c levels in DME patients (SF: r = 0.342; p = 0.017). Diabetes duration did not correlate significantly with choroidal thickness. CONCLUSION: SS-OCT measurements revealed that the choroid was significantly thinner in T2D patients, moderate non-proliferative diabetic retinopathy patients, and DME patients than in healthy individuals. Further studies are needed to clarify the effect of diabetes on this layer and the relationship between choroidal thickness and DME. |
format | Online Article Text |
id | pubmed-5796707 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-57967072018-02-16 Choroidal thickness measured using swept-source optical coherence tomography is reduced in patients with type 2 diabetes Abadia, Beatriz Suñen, Ines Calvo, Pilar Bartol, Francisco Verdes, Guayente Ferreras, Antonio PLoS One Research Article OBJECTIVE: To compare choroidal thickness between patients with type 2 diabetes (T2D) and healthy controls measured using swept-source optical coherence tomography (SS-OCT). METHODS: The sample comprised 157 eyes of 94 T2D patients, 48 eyes of which had diabetic macular edema (DME), and 71 normal eyes of 38 healthy patients. Subfoveal (SF) choroidal thickness, and choroidal thickness at 500-μm intervals up to 2500 μm nasal and temporal from the fovea were measured using the SS-OCT. Choroidal thicknesses were compared between groups using Student’s t-test. Additionally, Pearson correlations were calculated between diabetes duration, glycosylated hemoglobin (HbA1c) levels, and choroidal thickness. RESULTS: Mean diabetes duration was 16.6±9.5 years, while mean glycosylated hemoglobin was 7.7±1.3%. Overall, the choroid was significantly thinner in T2D patients. Individuals with DME had reduced choroidal thickness in all measurements, except at 2000 and 2500-μm nasal positions, compared to healthy controls. There was a moderate correlation between choroidal thickness and HbA1c levels in DME patients (SF: r = 0.342; p = 0.017). Diabetes duration did not correlate significantly with choroidal thickness. CONCLUSION: SS-OCT measurements revealed that the choroid was significantly thinner in T2D patients, moderate non-proliferative diabetic retinopathy patients, and DME patients than in healthy individuals. Further studies are needed to clarify the effect of diabetes on this layer and the relationship between choroidal thickness and DME. Public Library of Science 2018-02-02 /pmc/articles/PMC5796707/ /pubmed/29394291 http://dx.doi.org/10.1371/journal.pone.0191977 Text en © 2018 Abadia et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Abadia, Beatriz Suñen, Ines Calvo, Pilar Bartol, Francisco Verdes, Guayente Ferreras, Antonio Choroidal thickness measured using swept-source optical coherence tomography is reduced in patients with type 2 diabetes |
title | Choroidal thickness measured using swept-source optical coherence tomography is reduced in patients with type 2 diabetes |
title_full | Choroidal thickness measured using swept-source optical coherence tomography is reduced in patients with type 2 diabetes |
title_fullStr | Choroidal thickness measured using swept-source optical coherence tomography is reduced in patients with type 2 diabetes |
title_full_unstemmed | Choroidal thickness measured using swept-source optical coherence tomography is reduced in patients with type 2 diabetes |
title_short | Choroidal thickness measured using swept-source optical coherence tomography is reduced in patients with type 2 diabetes |
title_sort | choroidal thickness measured using swept-source optical coherence tomography is reduced in patients with type 2 diabetes |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796707/ https://www.ncbi.nlm.nih.gov/pubmed/29394291 http://dx.doi.org/10.1371/journal.pone.0191977 |
work_keys_str_mv | AT abadiabeatriz choroidalthicknessmeasuredusingsweptsourceopticalcoherencetomographyisreducedinpatientswithtype2diabetes AT sunenines choroidalthicknessmeasuredusingsweptsourceopticalcoherencetomographyisreducedinpatientswithtype2diabetes AT calvopilar choroidalthicknessmeasuredusingsweptsourceopticalcoherencetomographyisreducedinpatientswithtype2diabetes AT bartolfrancisco choroidalthicknessmeasuredusingsweptsourceopticalcoherencetomographyisreducedinpatientswithtype2diabetes AT verdesguayente choroidalthicknessmeasuredusingsweptsourceopticalcoherencetomographyisreducedinpatientswithtype2diabetes AT ferrerasantonio choroidalthicknessmeasuredusingsweptsourceopticalcoherencetomographyisreducedinpatientswithtype2diabetes |