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Impact of childhood wheezing on lung function in adulthood: A meta-analysis

BACKGROUND: A growing body of evidence shows that childhood wheezing may lead to recurrent or persistent symptoms in adulthood, such that persistent wheezing associated with lung function deficits often have their roots in the first few years of life. OBJECTIVES: We summarized information from sever...

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Autores principales: Ma, Huan, Li, Yuanyuan, Tang, Lin, Peng, Xin, Jiang, Lili, Wan, Jiao, Suo, Fengtao, Zhang, Guangli, Luo, Zhengxiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796725/
https://www.ncbi.nlm.nih.gov/pubmed/29394280
http://dx.doi.org/10.1371/journal.pone.0192390
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author Ma, Huan
Li, Yuanyuan
Tang, Lin
Peng, Xin
Jiang, Lili
Wan, Jiao
Suo, Fengtao
Zhang, Guangli
Luo, Zhengxiu
author_facet Ma, Huan
Li, Yuanyuan
Tang, Lin
Peng, Xin
Jiang, Lili
Wan, Jiao
Suo, Fengtao
Zhang, Guangli
Luo, Zhengxiu
author_sort Ma, Huan
collection PubMed
description BACKGROUND: A growing body of evidence shows that childhood wheezing may lead to recurrent or persistent symptoms in adulthood, such that persistent wheezing associated with lung function deficits often have their roots in the first few years of life. OBJECTIVES: We summarized information from several prospective cohort studies following children with or without wheezing into adulthood, to estimate the effect of childhood wheezing on adulthood lung function. METHODS: Medical literatures were searched in the Medline, PubMed, ScienceDirect, Web of Science and Embase databases up to October 31, 2016. The adulthood lung function was selected as primary outcome, and chronic obstructive pulmonary disease (COPD) prevalence was selected as secondary outcome. The meta-analysis was performed with the Stata Version 14.0. A random-effects model was applied to estimate standardized mean difference (SMD) of lung function, and relative risk (RR) of COPD. RESULTS: Six articles enrolling 1141 and 1005 children with and without wheezing, respectively. Meta-analysis showed that childhood wheezing decreased adulthood lung function as compared with no-wheezing subjects (SMD = -0.365, 95% confidence interval (CI): -0.569~-0.161, P = 0.000). Subgroup analyses indicated that childhood atopic wheezing reduced adulthood FEV1/FVC and FEV1%pred when compared with no-wheezing subjects. In addition, childhood atopic wheezing was significantly associated with COPD prevalence (RR = 5.307, 95% CI:1.033~27.271, P = 0.046). CONCLUSIONS: Our meta-analysis suggests that childhood wheezing may induce ongoing declined lung function that extends into adult life, as well as an increased risk of COPD prevalence when accompanied with atopy.
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spelling pubmed-57967252018-02-16 Impact of childhood wheezing on lung function in adulthood: A meta-analysis Ma, Huan Li, Yuanyuan Tang, Lin Peng, Xin Jiang, Lili Wan, Jiao Suo, Fengtao Zhang, Guangli Luo, Zhengxiu PLoS One Research Article BACKGROUND: A growing body of evidence shows that childhood wheezing may lead to recurrent or persistent symptoms in adulthood, such that persistent wheezing associated with lung function deficits often have their roots in the first few years of life. OBJECTIVES: We summarized information from several prospective cohort studies following children with or without wheezing into adulthood, to estimate the effect of childhood wheezing on adulthood lung function. METHODS: Medical literatures were searched in the Medline, PubMed, ScienceDirect, Web of Science and Embase databases up to October 31, 2016. The adulthood lung function was selected as primary outcome, and chronic obstructive pulmonary disease (COPD) prevalence was selected as secondary outcome. The meta-analysis was performed with the Stata Version 14.0. A random-effects model was applied to estimate standardized mean difference (SMD) of lung function, and relative risk (RR) of COPD. RESULTS: Six articles enrolling 1141 and 1005 children with and without wheezing, respectively. Meta-analysis showed that childhood wheezing decreased adulthood lung function as compared with no-wheezing subjects (SMD = -0.365, 95% confidence interval (CI): -0.569~-0.161, P = 0.000). Subgroup analyses indicated that childhood atopic wheezing reduced adulthood FEV1/FVC and FEV1%pred when compared with no-wheezing subjects. In addition, childhood atopic wheezing was significantly associated with COPD prevalence (RR = 5.307, 95% CI:1.033~27.271, P = 0.046). CONCLUSIONS: Our meta-analysis suggests that childhood wheezing may induce ongoing declined lung function that extends into adult life, as well as an increased risk of COPD prevalence when accompanied with atopy. Public Library of Science 2018-02-02 /pmc/articles/PMC5796725/ /pubmed/29394280 http://dx.doi.org/10.1371/journal.pone.0192390 Text en © 2018 Ma et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ma, Huan
Li, Yuanyuan
Tang, Lin
Peng, Xin
Jiang, Lili
Wan, Jiao
Suo, Fengtao
Zhang, Guangli
Luo, Zhengxiu
Impact of childhood wheezing on lung function in adulthood: A meta-analysis
title Impact of childhood wheezing on lung function in adulthood: A meta-analysis
title_full Impact of childhood wheezing on lung function in adulthood: A meta-analysis
title_fullStr Impact of childhood wheezing on lung function in adulthood: A meta-analysis
title_full_unstemmed Impact of childhood wheezing on lung function in adulthood: A meta-analysis
title_short Impact of childhood wheezing on lung function in adulthood: A meta-analysis
title_sort impact of childhood wheezing on lung function in adulthood: a meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796725/
https://www.ncbi.nlm.nih.gov/pubmed/29394280
http://dx.doi.org/10.1371/journal.pone.0192390
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