Cargando…

Optimal control of asthma improved eosinophilic otitis media

BACKGROUND: Eosinophilic otitis media (EOM) is often associated with comorbid asthma. The middle ear cavity is part of the upper airway. Therefore, EOM and asthma can be considered to be a crucial part of the “one airway, one disease” phenomenon. Based on the concept of one airway, one disease in th...

Descripción completa

Detalles Bibliográficos
Autores principales: Seo, Yukako, Nonaka, Manabu, Yamamura, Yukie, Pawankar, Ruby, Tagaya, Etsuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796965/
https://www.ncbi.nlm.nih.gov/pubmed/29423372
http://dx.doi.org/10.5415/apallergy.2018.8.e5
_version_ 1783297578393141248
author Seo, Yukako
Nonaka, Manabu
Yamamura, Yukie
Pawankar, Ruby
Tagaya, Etsuko
author_facet Seo, Yukako
Nonaka, Manabu
Yamamura, Yukie
Pawankar, Ruby
Tagaya, Etsuko
author_sort Seo, Yukako
collection PubMed
description BACKGROUND: Eosinophilic otitis media (EOM) is often associated with comorbid asthma. The middle ear cavity is part of the upper airway. Therefore, EOM and asthma can be considered to be a crucial part of the “one airway, one disease” phenomenon. Based on the concept of one airway, one disease in the context of allergic rhinitis and asthma, optimal level of inhalation therapy for better asthma control leads to improvement in allergic rhinitis. OBJECTIVE: We conducted a pilot study to determine whether appropriate strengthening of inhalation therapy for asthma is effective for EOM. METHODS: Fifteen patients with EOM and comorbid asthma were enrolled in this study. Eight patients were randomly selected and administered appropriately strengthened inhalation therapy for asthma (strengthened group). The effect of the therapy on EOM was assessed by comparing a questionnaire for ear symptoms, clinical characteristic score, pure tone audiometry, blood tests and temporal bone computed tomography (CT) examination before and after the therapy. Seven other EOM + asthma patients without the above mentioned therapy were included as controls. RESULTS: In the strengthened group, the score of ear symptoms, clinical characteristics score, peripheral blood eosinophil count, CT score, and air conduction hearing level improved significantly after strengthening the inhalation therapy, but not in the control group. The lung function tests (forced vital capacity [%predicted], forced expiratory volume in 1 second [FEV(1)] [L], and FEV(1) [%predicted]) significantly increased in the strengthened group after the therapy, but not in the control group. CONCLUSION: In this study we demonstrated that EOM improved along with improved lung function when appropriately optimal inhalation therapy was implemented in patients with EOM and asthma. Administration of optimizing therapy for asthma might be effective for concomitant EOM.
format Online
Article
Text
id pubmed-5796965
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Asia Pacific Association of Allergy, Asthma and Clinical Immunology
record_format MEDLINE/PubMed
spelling pubmed-57969652018-02-08 Optimal control of asthma improved eosinophilic otitis media Seo, Yukako Nonaka, Manabu Yamamura, Yukie Pawankar, Ruby Tagaya, Etsuko Asia Pac Allergy Hypothesis & Experience BACKGROUND: Eosinophilic otitis media (EOM) is often associated with comorbid asthma. The middle ear cavity is part of the upper airway. Therefore, EOM and asthma can be considered to be a crucial part of the “one airway, one disease” phenomenon. Based on the concept of one airway, one disease in the context of allergic rhinitis and asthma, optimal level of inhalation therapy for better asthma control leads to improvement in allergic rhinitis. OBJECTIVE: We conducted a pilot study to determine whether appropriate strengthening of inhalation therapy for asthma is effective for EOM. METHODS: Fifteen patients with EOM and comorbid asthma were enrolled in this study. Eight patients were randomly selected and administered appropriately strengthened inhalation therapy for asthma (strengthened group). The effect of the therapy on EOM was assessed by comparing a questionnaire for ear symptoms, clinical characteristic score, pure tone audiometry, blood tests and temporal bone computed tomography (CT) examination before and after the therapy. Seven other EOM + asthma patients without the above mentioned therapy were included as controls. RESULTS: In the strengthened group, the score of ear symptoms, clinical characteristics score, peripheral blood eosinophil count, CT score, and air conduction hearing level improved significantly after strengthening the inhalation therapy, but not in the control group. The lung function tests (forced vital capacity [%predicted], forced expiratory volume in 1 second [FEV(1)] [L], and FEV(1) [%predicted]) significantly increased in the strengthened group after the therapy, but not in the control group. CONCLUSION: In this study we demonstrated that EOM improved along with improved lung function when appropriately optimal inhalation therapy was implemented in patients with EOM and asthma. Administration of optimizing therapy for asthma might be effective for concomitant EOM. Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2018-01-24 /pmc/articles/PMC5796965/ /pubmed/29423372 http://dx.doi.org/10.5415/apallergy.2018.8.e5 Text en Copyright © 2018. Asia Pacific Association of Allergy, Asthma and Clinical Immunology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Hypothesis & Experience
Seo, Yukako
Nonaka, Manabu
Yamamura, Yukie
Pawankar, Ruby
Tagaya, Etsuko
Optimal control of asthma improved eosinophilic otitis media
title Optimal control of asthma improved eosinophilic otitis media
title_full Optimal control of asthma improved eosinophilic otitis media
title_fullStr Optimal control of asthma improved eosinophilic otitis media
title_full_unstemmed Optimal control of asthma improved eosinophilic otitis media
title_short Optimal control of asthma improved eosinophilic otitis media
title_sort optimal control of asthma improved eosinophilic otitis media
topic Hypothesis & Experience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796965/
https://www.ncbi.nlm.nih.gov/pubmed/29423372
http://dx.doi.org/10.5415/apallergy.2018.8.e5
work_keys_str_mv AT seoyukako optimalcontrolofasthmaimprovedeosinophilicotitismedia
AT nonakamanabu optimalcontrolofasthmaimprovedeosinophilicotitismedia
AT yamamurayukie optimalcontrolofasthmaimprovedeosinophilicotitismedia
AT pawankarruby optimalcontrolofasthmaimprovedeosinophilicotitismedia
AT tagayaetsuko optimalcontrolofasthmaimprovedeosinophilicotitismedia