Cargando…

Activation of MAPK signalling results in resistance to saracatinib (AZD0530) in ovarian cancer

SRC tyrosine kinase is frequently overexpressed and activated in late-stage, poor prognosis ovarian tumours, and preclinical studies have supported the use of targeted SRC inhibitors in the treatment of this disease. The SAPPROC trial investigated the addition of the SRC inhibitor saracatinib (AZD05...

Descripción completa

Detalles Bibliográficos
Autores principales:	McGivern, Niamh, El-Helali, Aya, Mullan, Paul, McNeish, Iain A., Paul Harkin, D., Kennedy, Richard D., McCabe, Nuala
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797008/ https://www.ncbi.nlm.nih.gov/pubmed/29435137 http://dx.doi.org/10.18632/oncotarget.23524

Ejemplares similares

Phase I study of saracatinib (AZD0530) in combination with paclitaxel and/or carboplatin in patients with solid tumours
por: Kaye, S, et al.
Publicado: (2012)

Exploring the benefits of in-diet versus repeated oral dosing of saracatinib (AZD0530) in chronic studies: insights into pharmacokinetics and animal welfare
por: Vasanthi, Suraj S., et al.
Publicado: (2023)

Aromatase inhibition plus/minus Src inhibitor saracatinib (AZD0530) in advanced breast cancer therapy (ARISTACAT): a randomised phase II study
por: Oswald, Ailsa J., et al.
Publicado: (2023)

A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer’s disease
por: Nygaard, Haakon B, et al.
Publicado: (2015)

Results of a Randomized, Double-Blinded, Placebo-Controlled, Phase 2.5 Study of Saracatinib (AZD0530), in Patients with Recurrent Osteosarcoma Localized to the Lung
por: Baird, Kristin, et al.
Publicado: (2020)

Mechanisms of disease-modifying effect of saracatinib (AZD0530), a Src/Fyn tyrosine kinase inhibitor, in the rat kainate model of temporal lobe epilepsy
por: Sharma, Shaunik, et al.
Publicado: (2021)

An EMT spectrum defines an anoikis-resistant and spheroidogenic intermediate mesenchymal state that is sensitive to e-cadherin restoration by a src-kinase inhibitor, saracatinib (AZD0530)
por: Huang, R Y-J, et al.
Publicado: (2013)

Effect of AZD0530 on Cerebral Metabolic Decline in Alzheimer Disease: A Randomized Clinical Trial
por: van Dyck, Christopher H., et al.
Publicado: (2019)

The effect of the dual Src/Abl kinase inhibitor AZD0530 on Philadelphia positive leukaemia cell lines
por: Gwanmesia, Patricia Mambou, et al.
Publicado: (2009)

AZD0530 sensitizes drug‐resistant ALK‐positive lung cancer cells by inhibiting SRC signaling
por: Zhao, Yi, et al.
Publicado: (2017)

Synergistic effect of STAT3-targeted small interfering RNA and AZD0530 against glioblastoma in vitro and in vivo
por: Liu, Qingjun, et al.
Publicado: (2019)

Student polling software: where cognitive psychology meets educational practice?
por: McGivern, Paul, et al.
Publicado: (2015)

The impact of COVID-19 on UK university students: Understanding the interconnection of issues experienced during lockdown
por: McGivern, Paul, et al.
Publicado: (2022)

Follow Up After PEG Tube Insertion
por: McGivern, Margaret
Publicado: (2007)

Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer
por: Parkes, Eileen E., et al.
Publicado: (2016)

Ziconotide: a review of its pharmacology and use in the treatment of pain
por: McGivern, Joseph G
Publicado: (2007)

The role of PTEN as a cancer biomarker
por: McCabe, Nuala, et al.
Publicado: (2016)

Saracatinib is an efficacious clinical candidate for fibrodysplasia ossificans progressiva
por: Williams, Eleanor, et al.
Publicado: (2021)

Strategies to Optimise Oncolytic Viral Therapies: The Role of Natural Killer Cells
por: Leung, Elaine Y. L., et al.
Publicado: (2021)

The impact of pop-up warning messages of losses on expenditure in a simulated game of online roulette: a pilot study
por: McGivern, Paul, et al.
Publicado: (2019)

DNA Repair Deficiency in Breast Cancer: Opportunities for Immunotherapy
por: Gilmore, Elaine, et al.
Publicado: (2019)

Saracatinib synergizes with enzalutamide to downregulate AR activity in CRPC
por: White, Ralph E., et al.
Publicado: (2023)

‘Pastoral practices’ for quality improvement in a Kenyan clinical network
por: McGivern, Gerry, et al.
Publicado: (2017)

Examining clinical leadership in Kenyan public hospitals through the distributed leadership lens
por: Nzinga, Jacinta, et al.
Publicado: (2018)

Hybrid clinical-managers in Kenyan hospitals: Navigating between professional, official and practical norms
por: Nzinga, Jacinta, et al.
Publicado: (2019)

Alcohol attention bias in 14-16 year old adolescents: an eye tracking study
por: McGivern, Casey, et al.
Publicado: (2020)

The potential and challenges of targeting MTAP-negative cancers beyond synthetic lethality
por: Bray, Chandler, et al.
Publicado: (2023)

A case of limbic encephalitis presenting as a paraneoplastic manifestation of limited stage small cell lung cancer: a case report
por: Fahim, Ahmed, et al.
Publicado: (2010)

Mechanisms of diarrhoea
por: Booth, I.W., et al.
Publicado: (1993)

Practical guidance for the management of side effects during rucaparib therapy in a multidisciplinary UK setting
por: Tookman, Laura, et al.
Publicado: (2020)

Prior knowledge transfer across transcriptional data sets and technologies using compositional statistics yields new mislabelled ovarian cell line
por: Blayney, Jaine K., et al.
Publicado: (2016)

Saracatinib Inhibits Middle East Respiratory Syndrome-Coronavirus Replication In Vitro
por: Shin, Jin Soo, et al.
Publicado: (2018)

Saracatinib Fails to Reduce Alcohol-Seeking and Consumption in Mice and Human Participants
por: Thompson, Summer L., et al.
Publicado: (2021)

Mainstreaming as rhetoric or reality? Gender and global health at the World Bank
por: Winters, Janelle, et al.
Publicado: (2018)

Editorial: Rising stars in vascular physiology: 2022
por: Tulis, David A., et al.
Publicado: (2023)

Sex differences in implicit processing of allocentric relationships between objects and location in a Simon task
por: Mosso, Matthew, et al.
Publicado: (2020)

CD40 ligand induced cytotoxicity in carcinoma cells is enhanced by inhibition of metalloproteinase cleavage and delivery via a conditionally-replicating adenovirus
por: Elmetwali, Taha, et al.
Publicado: (2010)

Variability in the use of pulse oximeters with children in Kenyan hospitals: A mixed-methods analysis
por: Enoch, Abigail J., et al.
Publicado: (2019)

The Emerging Role of Interleukin 1β (IL-1β) in Cancer Cachexia
por: Laird, Barry J., et al.
Publicado: (2021)

PTTG1 Levels Are Predictive of Saracatinib Sensitivity in Ovarian Cancer Cell Lines
por: Nakachi, I, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_nd209e0k9kissuqpre5sq0cqaq