Triplications of human chromosome 21 orthologous regions in mice result in expansion of megakaryocyte-erythroid progenitors and reduction of granulocyte-macrophage progenitors

Individuals with Down syndrome (DS) frequently have hematopoietic abnormalities, including transient myeloproliferative disorder and acute megakaryoblastic leukemia which are often accompanied by acquired GATA1 mutations that produce a truncated protein, GATA1s. The mouse has been used for modeling...

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Detalles Bibliográficos
Autores principales: Liu, Chunhong, Yu, Tao, Xing, Zhuo, Jiang, Xiaoling, Li, Yichen, Pao, Annie, Mu, Justin, Wallace, Paul K., Stoica, George, Bakin, Andrei V., Yu, Y. Eugene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797011/
https://www.ncbi.nlm.nih.gov/pubmed/29435140
http://dx.doi.org/10.18632/oncotarget.23463

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