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Osteopontin–integrin engagement induces HIF-1α–TCF12-mediated endothelial-mesenchymal transition to exacerbate colorectal cancer

Osteopontin (OPN) is a multi-functional phospho-glycoprotein that can stimulate angiogenesis through acting on endothelial cells. As angiogenic sprouting involves endothelial-to-mesenchymal transition (EndoMT), we are intrigued to know whether OPN exerts an effect on EndoMT. Clinically, we indeed de...

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Detalles Bibliográficos
Autores principales:	Fan, Chi-Shuan, Chen, Wei-Shone, Chen, Li-Li, Chen, Chia-Chi, Hsu, Yu-Ting, Chua, Kee Voon, Wang, Horng-Dar, Huang, Tze-Sing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797029/ https://www.ncbi.nlm.nih.gov/pubmed/29435158 http://dx.doi.org/10.18632/oncotarget.23578

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